Childhood maltreatment and inflammation: Leveraging structural equation modeling to test the social signal transduction theory of depression

O'Shields, Jay; Patel, Dipali; Mowbray, Orion

doi:10.1016/j.jad.2022.05.077

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Recent research indicates that childhood stress, trauma, and abuse events are associated with inflammation in adulthood ( 11 – 15 ). Additionally, childhood abuse experiences are linked to negative outcomes such as adverse cardiometabolic conditions and depression in adulthood ( 16 – 17 ). There is also a significant association between ACEs and inflammatory biomarkers ( 18 ).…”

Section: Resultsmentioning

confidence: 99%

Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers: A Life Course Perspective

Zhang Bo Lua,

Gao,

et al. 2024

China CDC Weekly

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Assessing individual risks of healthy aging using biomarkers and identifying associated factors have become important areas of research. In this study, we conducted a literature review of relevant publications between 2018 and 2023 in both Chinese and English databases. Previous studies have predominantly used single biomarkers, such as C-reactive protein, or focused on specific life course stages and factors such as socioeconomic status, mental health, educational levels, and unhealthy lifestyles. By summarizing the progress in this field, our study provides valuable insights and future directions for promoting healthy aging from a life course perspective.

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Section: Resultsmentioning

confidence: 99%

Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers: A Life Course Perspective

Zhang Bo Lua,

Gao,

et al. 2024

China CDC Weekly

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“…47,48 A study including more than 2000 participants identified that childhood maltreatment had a significant positive relationship with inflammation as well as depressive symptoms. 49 Further, a study of 164 patients with MDD and 301 healthy control persons 50 investigated the associations between childhood maltreatment and levels of 41 inflammatory markers in the two groups.…”

mentioning

confidence: 99%

Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss

Vinberg,

McIntyre,

Giraldi

et al. 2024

NDT

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The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.

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Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis

O'Shields¹,

Graves²,

Mowbray³

2023

Brain, Behavior, & Immunity - Health

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Childhood maltreatment and inflammation: Leveraging structural equation modeling to test the social signal transduction theory of depression

Cited by 6 publications

References 57 publications

Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers: A Life Course Perspective

Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers: A Life Course Perspective

Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss

Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis

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