Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis

O'Shields, Jay; Graves, Brian D.; Mowbray, Orion

doi:10.1016/j.bbih.2023.100611

Cited by 3 publications

(1 citation statement)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies using MIDUS data demonstrated that inflammation predicted future within-person 9-year change in major depressive disorder diagnosis status (36) and that childhood maltreatment was related to inflammatory activity through negative affect (37). Finally, a network analysis of MIDUS data revealed positive correlations between childhood maltreatment and interleukin-6 (IL-6) on the one hand, and between IL-6 and somatic symptoms of depression on the other (38). These studies together demonstrate that inflammation may serve as a key biological mechanism and maintenance factor in trauma-associated depression and that these findings have been well established using MIDUS data.…”

Section: Introductionmentioning

confidence: 99%

Perceived Control and Inflammation: Mediating and Moderating Effects in the Relationship Between Cumulative Trauma and Depression

Magin,

Park,

Burke

et al. 2024

Psychosom Med

View full text Add to dashboard Cite

Objective The effects of trauma exposure on depression risk and severity are well-established, but psychosocial and biological factors that impact or explain those relationships remain poorly understood. This study examined the moderating and mediating effects of perceived control and inflammation in the relationship between trauma and depression. Methods Moderation analyses and longitudinal mediation analyses were conducted on data from 945 adults who completed all three waves (spanning around 19 years) of the MIDUS Study and the MIDUS Biomarker Study. Data were collected during a phone interview, self-report surveys distributed in the mail, and an in-person blood draw. Two dimensions of perceived control — mastery and constraints — were examined separately in all analyses. Results Perceived control did not significantly moderate the relationship between trauma and depression severity at MIDUS 2 (b = .03, SE = .02, p = .091). Constraints significantly mediated the relationship between trauma and MIDUS 3 depression (IE = 0.03, SE = .01, p = .016) but not after accounting for MIDUS 2 depression. Perceived control did not have a significant moderating effect in the relationships between trauma and inflammation or inflammation and depression. Conclusions Findings from this study revealed that perceived control may be better characterized as an explanatory factor rather than a buffer in trauma-associated depression. Perceived constraints in particular may be a useful treatment target for trauma-associated depression. Further research is needed to examine whether these results generalize to populations other than among mostly non-Hispanic white adults in the United States.

show abstract

Section: Introductionmentioning

confidence: 99%

Perceived Control and Inflammation: Mediating and Moderating Effects in the Relationship Between Cumulative Trauma and Depression

Magin,

Park,

Burke

et al. 2024

Psychosom Med

View full text Add to dashboard Cite

show abstract

Network analysis of depressive symptoms in South Korean adults: Similarities and differences between women and men

Kim

2023

Curr Psychol

View full text Add to dashboard Cite

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Beydoun,

Wassertheil-Smoller

et al. 2024

Transl Psychiatry

View full text Add to dashboard Cite

Inflammation can play a role in the pathophysiology of depression, and specific types of antidepressants may have inflammatory or anti-inflammatory properties. Furthermore, depression and antidepressant use has been linked to white blood cell (WBC) count, a routinely measured inflammatory marker. We examined the cross-sectional and longitudinal relationships of depressive symptoms and/or antidepressant use with WBC count among postmenopausal women. Analyses of cross-sectional data at enrollment were performed on 125,307 participants, 50–79 years of age, from the Women’s Health Initiative Clinical Trials and Observational Studies who met eligibility criteria, and a subset of those with 3-year follow-up data were examined for longitudinal relationships. Depressive symptoms were defined using the Burnam Algorithm whereas antidepressant use was defined using therapeutic class codes. WBC count (Kcell/ml) was obtained through laboratory evaluations of fasting blood samples. Multivariable regression modeling was performed taking sociodemographic, lifestyle and health characteristics into consideration. At enrollment, nearly 85% were non-users of antidepressants with no depressive symptoms, 5% were antidepressant users with no depressive symptoms, 9% were non-users of antidepressants with depressive symptoms, and 2% were users of antidepressants with depressive symptoms. In fully-adjusted models, cross-sectional relationships were observed whereby women in the 2nd (OR = 1.06, 95% CI: 1.01, 1.13), 3rd (OR = 1.06, 95% CI: 1.00, 1.12) or 4th (OR = 1.10, 95% CI: 1.05, 1.17) quartiles of WBC count were more likely to exhibit depressive symptoms, and women in the 4th quartile were more likely to be users of antidepressants (OR = 1.07, 95% CI: 1.00, 1.15), compared to women in the 1st quartile. Compared to women who exhibited no depressive symptoms at either visit, those with consistent depressive symptoms at enrollment and at 3-year follow-up had faster decline in WBC count (β = −0.73, 95% CI: −1.33, −0.14) over time. No significant bidirectional relationships were observed between changes in depressive symptoms score and WBC count over time. In conclusion, depressive symptoms and/or antidepressant use were cross-sectionally related to higher WBC counts among postmenopausal women. Further evaluation of observed relationships is needed in the context of prospective cohort studies involving older adult men and women, with repeated measures of depression, antidepressant use, and WBC count.

show abstract

Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis

Cited by 3 publications

References 82 publications

Perceived Control and Inflammation: Mediating and Moderating Effects in the Relationship Between Cumulative Trauma and Depression

Perceived Control and Inflammation: Mediating and Moderating Effects in the Relationship Between Cumulative Trauma and Depression

Network analysis of depressive symptoms in South Korean adults: Similarities and differences between women and men

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Contact Info

Product

Resources

About