Childhood leukemia and lymphoma: time trends and factors affecting survival in five Southern and Eastern European Cancer Registries

Petridou, Eleni; Dimitrova, Nadya; Качанов, Д. Ю.; Karakilinc, Hulya; Варфоломеева, С. Р.; Belechri, Maria; Baka, Margarita; Moschovi, Maria; Polychronopoulou, Sofia; Athanasiadou-Piperopoulou, Fani; Fragandrea, Ioanna; Stiakaki, Eftichia; Pourtsidis, Apostolos; Stefanadis, Christodoulos; Coebergh, Jan Willem; Sergentanis, Theodoros N.

doi:10.1007/s10552-013-0188-y

Cited by 32 publications

(30 citation statements)

References 26 publications

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“…A study from Australia, a country with vast areas of very low density population, reported better survival rates for all childhood cancers and specifically leukaemia for children living in major cities compared to those living elsewhere . Living in rural areas was also associated with less favourable prognosis in recent multi‐national findings from Bulgaria, Turkey and Russia for survival from leukaemia as well as from lymphoma . However, in Denmark four specialised paediatric clinics cover the entire country, with relatively short distances to the treating centre from most places in Denmark and highly standardised treatment irrespective of the treating hospital.…”

Section: Discussionmentioning

confidence: 99%

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Erdmann

Winther

Dalton

et al. 2017

Intl Journal of Cancer

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Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated. Hazard ratios (HRs) for all CNS tumours combined did not show strong associations between survival and any family characteristic. Analyses by CNS tumour subtypes showed reduced survival for children with glioma when living outside of Copenhagen (HR 1.55; CI 1.03; 2.35). For embryonal CNS tumours, the number of full siblings was associated with worse survival (HR for having 3+ siblings 3.60; CI 1.52; 8.53) and a trend of better survival was observed for children with parents of younger age at child's diagnosis and poorer survival of children with parents of older age. Despite free and uniform access to health care services, some family circumstances appear to affect survival from specific CNS tumour types in Danish children. Further research is warranted to gain a more comprehensive understanding of the impact of family factors on childhood cancer survival in other populations and to elaborate underlying mechanisms and pathways of those survival inequalities observed.

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Section: Discussionmentioning

confidence: 99%

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Erdmann

Winther

Dalton

et al. 2017

Intl Journal of Cancer

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show abstract

“…This gap increases with the enlargement of the definition of Europe. Many registries however contributed to international studies of incidence and survival dedicated specifically to childhood cancer [70,71] and data from new areas emerge [72]. Registries with more expertise often offer help to the developing ones through 'twinning' activities, such as hosting collaborators from Hungarian childhood registry by the UK's NRCT or consultations provided by Germany to the registry in the Moscow region.…”

Section: Discussionmentioning

confidence: 99%

Registration of childhood cancer: Moving towards pan-European coverage?

Steliarova‐Foucher

Stiller

Colombet

et al. 2015

European Journal of Cancer

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“…In Greece, the time trend similarly increased on average by 0.99% annually [95% confidence interval (CI): 0.03-2.60] during the period 1996-2013 (Petridou et al, 2013;NARECHEM-BT, 2014). Similarly, during the same period, CD has gained popularity in the developed world, with rates well above the 15% recommended by WHO (Gibbons et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Prelabor cesarean delivery and early-onset acute childhood leukemia risk

Thomopoulos

Skalkidou

Dessypris

et al. 2016

European Journal of Cancer Prevention

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The long-term impact of cesarean delivery (CD) on the health of the offspring is being explored methodically. We sought to investigate the effect of birth by (a) prelabor and (b) during-labor CD on the risk of early-onset (≤3 years) acute lymphoblastic leukemia (ALL), specifically of its prevailing precursor B (B-ALL) subtype. A total of 1099 incident cases of ALL (957 B-ALL), 131 of acute myeloid leukemia (AML), and their 1 : 1 age-matched and sex-matched controls, derived from the Nationwide Registry for Childhood Hematological Malignancies (1996-2013), were analyzed using multivariate regression models. A null association was found between prelabor and/or during labor CD and either ALL (B-ALL) or AML in the 0-14 age range. By contrast, birth by CD increased significantly the risk of early-onset ALL [odds ratioCD (ORCD)=1.57, 95% confidence interval (CI): 1.10-2.24] mainly on account of prelabor CD (ORprelaborCD=1.66, 95% CI: 1.13-2.43). The respective figures were even higher for the early-onset precursor B-ALL (ORCD=1.66, 95% CI: 1.15-2.40 and ORprelaborCD=1.79, 95% CI: 1.21-2.66), whereas no association emerged for early-onset AML. Prelabor CD, which deprives exposure of the fetus/infant to the presumably beneficial effect of stress hormones released in both vaginal labor and during labor CD, was associated exclusively with an increased risk of early-onset ALL, particularly the precursor B-ALL subtype. If confirmed, these adverse long-term outcomes of CD may point to re-evaluation of prelabor CD practices and prompt scientific discussion on the best ways to simulate the effects of vaginal delivery, such as a precesarean induction of labor.

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Childhood leukemia and lymphoma: time trends and factors affecting survival in five Southern and Eastern European Cancer Registries

Abstract: The favorable mortality trends highlight the progress in Southern-Eastern European countries along their trajectory to converge with Northern-Western EU counterpart states. Socioeconomic status may act as a multipotent factor underlying the study findings.

Cited by 32 publications

References 26 publications

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Registration of childhood cancer: Moving towards pan-European coverage?

Prelabor cesarean delivery and early-onset acute childhood leukemia risk

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