Registration of childhood cancer: Moving towards pan-European coverage?

Steliarova‐Foucher, Eva; Stiller, Charles; Colombet, Murielle; Kaatsch, Peter; Zanetti, Roberto; Peris-Bonet, Rafael

doi:10.1016/j.ejca.2015.03.009

Cited by 35 publications

(52 citation statements)

References 59 publications

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“…Under-ascertainment of diagnosed cases might have resulted from administrative restrictions of access to medical files, political or social instability, competing needs, and inadequate political will, causing a dearth of resources, shortage or volatility of registry personnel, loss of perennial expertise, and missing or broken links with relevant data sources. Overestimates of incidence might have occurred in areas with superior treatment facilities if the place of permanent residence could not be correctly determined for registered patients, and national coverage would neutralise such artefactual regional differences within a country 15 . Accurate incidence rates are also difficult to obtain in ethnic minorities, such as the Native American population in the USA, possibly because of imprecise classification of the at-risk population, as well as patients with cancer 16 .…”

Section: Discussionmentioning

confidence: 99%

International incidence of childhood cancer, 2001–10: a population-based registry study

Steliarova‐Foucher¹,

Colombet²,

Ries³

et al. 2017

The Lancet Oncology

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SummaryBackgroundCancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control.MethodsThis population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s.FindingsOf 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years.InterpretationThis unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research.FundingInternational Agency for Research on Cancer and the Union for International Cancer Control.

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Section: Discussionmentioning

confidence: 99%

International incidence of childhood cancer, 2001–10: a population-based registry study

Steliarova‐Foucher¹,

Colombet²,

Ries³

et al. 2017

The Lancet Oncology

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1,201

890

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“…The regional registries were also population‐based fully covering their area of study and were included to increase representability in the region of SEE. Besides the two Romanian registries, all others fulfilled the quality criteria of and were included in the International Incidence of Childhood Cancer 3 project (IICC‐3) . All malignant neuroblastoma cases diagnosed in children aged 0–14 years during respective registration periods of the contributing registries spanning circa 1990–2016 were eligible for inclusion.…”

Section: Methodsmentioning

confidence: 99%

“…Besides the two Romanian registries, all others fulfilled the quality criteria of and were included in the International Incidence of Childhood Cancer 3 project (IICC-3). 17,18 All malignant neuroblastoma cases diagnosed in children aged 0-14 years during respective registration periods of the contributing registries spanning circa 1990-2016 were eligible for inclusion. In addition, all cases of neuroblastoma incident in 1990-2012 were extracted from the SEER database, which covers 29% of the US childhood population.…”

Section: Cancer Epidemiologymentioning

confidence: 99%

Neuroblastoma among children in Southern and Eastern European cancer registries: Variations in incidence and temporal trends compared to US

Georgakis

Dessypris

Baka

et al. 2017

Intl Journal of Cancer

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Neuroblastoma comprises the most common neoplasm during infancy (first year of life). Our study describes incidence of neuroblastoma in Southern-Eastern Europe (SEE), including - for the first time - the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST)/Greece, compared to the US population, while controlling for human development index (HDI). Age-adjusted incidence rates (AIR) were calculated for 1,859 childhood (0-14 years) neuroblastoma cases, retrieved from 13 collaborating SEE registries (1990-2016), and were compared to those of SEER/US (N = 3,166; 1990-2012); temporal trends were assessed using Poisson regression and Joinpoint analyses. The overall AIR was significantly lower in SEE (10.1/million) compared to SEER (11.7 per million); the difference was maximum during infancy (43.7 vs. 53.3 per million, respectively), when approximately one-third of cases were diagnosed. Incidence rates of neuroblastoma at ages <1 and 1-4 years were positively associated with HDI, whereas lower median age at diagnosis was correlated with higher overall AIR. Distribution of primary site and histology was similar in SEE and SEER. Neuroblastoma was slightly more common among males compared to females (male-to-female ratio: 1.1), mainly among SEE infants. Incidence trends decreased in infants in Slovenia, Cyprus and SEER and increased in Ukraine and Belarus. The lower incidence in SEE compared to SEER, especially in infants living in low HDI countries possibly indicates a lower level of overdiagnosis in SEE. Hence, increases in incidence rates in infancy noted in some subpopulations should be carefully monitored to avoid the unnecessary costs health impacts of tumors that could potentially spontaneously regress.

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“…The estimated incidence of cancer among children under the age of 15 years in Europe for 2012 was 13.9 per 100.000 children . Nearly 15% of deaths among children aged 4–14 years in Europe are due to cancer, making this the leading disease causing death in children beyond infancy . Established risk factors for childhood cancer include ionization radiation and specific genetic syndromes like Down syndrome .…”

Section: Introductionmentioning

confidence: 99%

Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study

et al. 2017

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Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large nationwide cohort of 1,904,363 children born in Denmark from 1978 through 2010. The children were identified in the Danish Medical Birth Registry and were linked to information from other national registers, including the Danish Cancer Registry. In total, 3,492 children were diagnosed with cancer before the age of 15 years. The adjusted hazard ratio of childhood cancer according to paternal age was estimated using Cox proportional hazards regressions. We found a 13% (95% confidence interval: 4-23%) higher hazard rate for every 5 years advantage in paternal age for acute lymphoblastic leukemia, while no clear association was found for acute myeloid leukemia (hazard ratio pr. 5 years = 1.02, 95% confidence interval: 0.80-1.30). The estimates for neoplasms in the central nervous system suggested a lower hazard rate with higher paternal age (hazard ratio pr. 5 years = 0.92, 95% confidence interval: 0.84-1.01). No clear associations were found for the remaining childhood cancer types. The findings suggest that paternal age is moderately associated with a higher rate of childhood acute lymphoblastic leukemia, but not acute myeloid leukemia, in offspring, while no firm conclusions could be made for other specific cancer types.

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Registration of childhood cancer: Moving towards pan-European coverage?

Cited by 35 publications

References 59 publications

International incidence of childhood cancer, 2001–10: a population-based registry study

International incidence of childhood cancer, 2001–10: a population-based registry study

Neuroblastoma among children in Southern and Eastern European cancer registries: Variations in incidence and temporal trends compared to US

Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study

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