Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation

Schiffman, Jason; Pestle, Sarah L.; Mednick, Sara C.; Ekstrøm, Morten; Sørensen, Holger J.; Mednick, Sarnoff A.

doi:10.1016/j.schres.2004.04.003

Cited by 38 publications

(25 citation statements)

References 29 publications

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“…In our study, Annett's 7-way right-handers with strong/moderate left tendencies (i.e., mixed handed) were more psychosis-prone than pure right-handed subjects. These findings can be interpreted as being consistent with the hypothesized role of disrupted lateralization in the etiology of schizophrenia (e.g., Crow, 1990, Sommer et al, 2001, Schiffman et al, 2005and Oertel et al, 2010 and as a genetic risk marker for the disorder (e.g., Altamura et al, 2012).…”

Section: Discussionsupporting

confidence: 75%

Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Barrantes‐Vidal

Gómez-de-Regil

Navarro

et al. 2013

Psychiatry Research

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Section: Discussionsupporting

confidence: 75%

Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Barrantes‐Vidal

Gómez-de-Regil

Navarro

et al. 2013

Psychiatry Research

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“…This finding is in contrast with those of some studies that have found no gender differences in relation to handedness in schizophrenia whereas several authors have found an association between non-right handedness and the male gender [11][12][13][14][15] . Our study found no association between age at onset of illness and handedness in schizophrenia/ schizoaffective disorder.…”

Section: Discussioncontrasting

confidence: 99%

“…The relationship between gender, atypical handedness and schizophrenia has also been studied but the results are inconsistent. Some studies have found no gender differences in relation to handedness in schizophrenia whereas several authors have found an association between non-right handedness and the male gender [10][11][12][13][14][15] . In contrast, a study by Kenneth et al showed that patients with schizophrenia and their mentally well relatives had an excess of mixed handedness compared to controls, and this excess was specific to female patients suffering from schizophrenia.…”

Section: Journal Of Psychiatry • January 2014mentioning

confidence: 99%

Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Mataboge¹

2014

Afr J Psychiatry

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Objective: An association between the Leucine-rich repeat trans membrane neuronal 1 gene (LRRTM1), schizophrenia/ schizoaffective disorder and handedness was recently claimed to be established. This study aimed to test the hypothesis that Afrikaner patients with schizophrenia/schizoaffective disorder are more non-right handed than their non-affected firstdegree relatives and that of two separate control groups. The association between handedness, gender and age at onset of illness in the patients group was also determined. Method: Two cross-sectional studies were carried out, which compared the handedness of a group of 100 (30 females and 70 males) Afrikaner patients with schizophrenia/schizoaffective disorder, their non-affected first-degree relatives, and two separate control groups. Handedness was determined by the Edinburg Handedness Inventory (EHI). Results: Patients were found to be more right-handed than expected with only 17 out of 100 being non-right-handed compared to 11 out of 100 non-affected relatives; 36 out of 100 students and 75 out of 500 nonaffected Afrikaner participants. The students were significantly more non-right handed than the patient and family groups but no difference in handedness was found when comparing the patients, family members and 500 participant control group. There was no significant difference between age at onset of illness and handedness. A significant association between female gender and non-right handedness in the patient group was found but no gender difference in the family and student groups. A highly significant association was found between the male gender of the patients and student control group regarding handedness. A significant difference was found between the median EHI raw scores of the patients and the family members. The median EHI raw scores of the patients were significantly lower than their paired family members. Conclusion: The study failed to prove a leftward shift of handedness in the patients with Schizophrenia and Schizoaffective disorder in the Afrikaner Founder population. Whether or not LRRTM1 is indeed the genetic basis of handedness, remains unclear.

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“…In spite of Bishop's recommendation, since 1990 relatively few papers have been published on sensory and motor laterality in persons with genetic disorders. An excess of left-or mixedhandedness, assessed using the Edinburgh Handedness Inventory (Oldfield, 1971) was reported in patients according to schizophrenic subtypes (Dollfus et al, 2002), but this excess was not confirmed in a group of children who later developed a schizophrenia spectrum disorder (Schiffman et al, 2005). And in longitudinal studies on offspring of schizophrenic parents by Erlenmeyer-Kimling et al (2005), no significant differences were observed in the offspring who developed schizophrenic disorders.…”

Section: Introductionmentioning

confidence: 99%

Laterality in Persons with Intellectual Disability. I—Do Patients with Trisomy 21 and Williams–Beuren Syndrome Differ from Typically Developing Persons?

et al. 2006

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Persons with trisomy 21 (T21) and Williams-Beuren syndrome (WBS) have different brain abnormalities which may affect manual laterality. We assessed 45 persons with T21 and 34 with WBS (mean age 13) and 81 typically developing children (TD). Manual laterality was assessed with a fifteen-item task administered two times, and Bishop's card-reaching task. We found more left-handers in the T21 group compared to the other two groups. Inconsistent laterality was higher in the two groups with genetic diseases than in the TD group. For Bishop's test, both T21 and WBS participants were less right-oriented than the TD group. They displayed different response patterns in midline crossing when reaching for the cards, but did not display more midline crossing inhibition than the TD group. Is atypical handedness linked to specific genetic syndromes and, more specifically for persons with T21, to the trisomy of some of the genes?

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Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation

Cited by 38 publications

References 29 publications

Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Laterality in Persons with Intellectual Disability. I—Do Patients with Trisomy 21 and Williams–Beuren Syndrome Differ from Typically Developing Persons?

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