Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Barrantes‐Vidal, Neus; Gómez-de-Regil, Lizzette; Navarro, Blas; Vicens-Vilanova, Jordi; Obiols, Jordi E.; Kwapil, Thomas R.

doi:10.1016/j.psychres.2012.12.008

Cited by 18 publications

(6 citation statements)

References 57 publications

(84 reference statements)

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“…This is in line with a large body of work in samples who may be prone to psychotic-like experiences and increased propensity for magical ideation and show increased prevalence for mixed and non-right handedness (Asai and Tanno, 2009; Barrantes-Vidal et al, 2013; Bolinskey et al, 2013; Dragovic et al, 2005; Shaw et al, 2001). In a large sample of university students, increased schizotypy is associated with decreased right-handedness (Chen and Su, 2006; van der Hoorn et al, 2010).…”

Section: Discussionsupporting

confidence: 87%

“…Decreased handedness has been associated with schizotypy and positive symptoms of psychosis (Badzakova-Trajkov et al, 2011; Barrantes-Vidal et al, 2013). This is particularly relevant as a neural diathesis stress model of psychosis suggests that early vulnerabilities (e.g., genetics, obstetric complications) lead to altered brain development, which in adolescence interacts with stressful life events, eventually leading to the development of psychotic symptoms (Cornblatt et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period

Dean

Orr

Newberry

et al. 2016

Schizophrenia Research

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Background A body of work focusing on brain connectivity, language dominance, and motor laterality research suggests reduced hemispheric asymmetry is a core feature in schizophrenia. However, there is little consensus about whether reduced dominance is present in those at ultrahigh risk (UHR) for psychosis. Methods A total of 94 demonstrated right-handed neuroleptic free participants (38 UHR and 56 matched healthy controls) were assessed with structured clinical interviews and completed an innovative handwriting task using a digital tablet computer. A laterality quotient (LQ) was calculated using kinematic variables from the participant’s left and right hands. A subset of the sample (26 UHR and 29 controls) returned after 12-months to complete clinical interviews in order to examine relationships between handwriting laterality and progression of psychosis risk symptoms. Results The UHR group showed decreased dextrality compared to healthy controls. At the 12-month follow-up, decreased dextrality accounted for 8% of the variance in worsened positive symptoms within the UHR group. Conclusion The current results suggest that disrupted cerebral dominance is also present in the ultrahigh risk period and that decreased dextrality may serve as a novel biomarker for the progression of psychosis risk.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period

Dean

Orr

Newberry

et al. 2016

Schizophrenia Research

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“…Schizotypy is also a relevant predictive factor on examining adolescents at-high genetic risk [16] and at-high clinical risk for psychosis [17]. Furthermore, healthy adolescents and young adults who report schizotypal experiences also present subtle emotional, behavioural, neurocognitive, and/or social deficits [2], [4], [18]–[23], similar to those found in patients with psychosis and in those with schizotypal personality disorder. In addition, schizotypal traits and experiences share the same risk factor as evidenced in clinical psychosis (e.g., trauma, urbanicity, age) [24].…”

Section: Introductionmentioning

confidence: 80%

Testing Measurement Invariance of the Schizotypal Personality Questionnaire-Brief Scores across Spanish and Swiss Adolescents

et al. 2013

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BackgroundSchizotypy is a complex construct intimately related to psychosis. Empirical evidence indicates that participants with high scores on schizotypal self-report are at a heightened risk for the later development of psychotic disorders. Schizotypal experiences represent the behavioural expression of liability for psychotic disorders. Previous factorial studies have shown that schizotypy is a multidimensional construct similar to that found in patients with schizophrenia. Specifically, using the Schizotypal Personality Questionnaire-Brief (SPQ-B), the three-dimensional model has been widely replicated. However, there has been no in-depth investigation of whether the dimensional structure underlying the SPQ-B scores is invariant across countries.MethodsThe main goal of this study was to examine the measurement invariance of the SPQ-B scores across Spanish and Swiss adolescents. The final sample was made up of 261 Spanish participants (51.7% men; M = 16.04 years) and 241 Swiss participants (52.3% men; M = 15.94 years).ResultsThe results indicated that Raine et al.'s three-factor model presented adequate goodness-of-fit indices. Moreover, the results supported the measurement invariance (configural and partial strong invariance) of the SPQ-B scores across the two samples. Spanish participants scored higher on Interpersonal dimension than Swiss when latent means were compared.DiscussionThe study of measurement equivalence across countries provides preliminary evidence for the Raine et al.'s three-factor model and of the cross-cultural validity of the SPQ-B scores in adolescent population. Future studies should continue to examine the measurement invariance of the schizotypy and psychosis-risk syndromes across cultures.

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“…This two-factor structure is consistent across samples and demonstrates cross-cultural invariance (e.g., Kwapil, Ros-Morente, Silvia, & Barrantes-Vidal, 2012). The positive and negative schizotypy dimensions are associated with differential patterns of symptoms and impairment in cross-sectional questionnaire studies (e.g., Barrantes-Vidal, Gómez-de-Regil et al, 2013; Brown et al, 2008), interview studies (e.g., Barrantes-Vidal, Ros-Morente, & Kwapil, 2009), and laboratory studies (e.g., Kaczorowski, Barrantes-Vidal, & Kwapil, 2009), as well as in prospective interview studies (e.g., Kwapil, Gross, Silvia, & Barrantes-Vidal, 2013). Furthermore, these results have been supported in a cross-cultural validation study (Barrantes-Vidal, Gross et al, 2013) using Spanish-language versions of the WSS.…”

Section: Experience-sampling Methodology (Esm)mentioning

confidence: 99%

Psychometric schizotypy predicts psychotic-like, paranoid, and negative symptoms in daily life.

Barrantes‐Vidal¹,

Chun²,

Myin-Germeys³

et al. 2013

Journal of Abnormal Psychology

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121

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Positive and negative schizotypy exhibit differential patterns of impairment in social relations, affect, and functioning in daily life. However, studies have not examined the association of schizotypy with real-world expression of psychotic-like, paranoid, and negative symptoms. The present study employed experience-sampling methodology (ESM) to assess positive and negative schizotypy in daily life in a nonclinical sample of 206 Spanish young adults. Participants were prompted randomly 8 times daily for 1 week to complete assessments of their current symptoms and experiences. Positive schizotypy was associated with psychotic-like and paranoid symptoms in daily life. Negative schizotypy was associated with a subset of these symptoms and with negative symptoms in daily life. Momentary stress was associated with psychotic-like and paranoid symptoms, but only for those high in positive schizotypy. Social stress predicted momentary psychotic-like symptoms in both positive and negative schizotypy. Time-lagged analyses indicated that stress at the preceding signal predicted psychotic-like symptoms at the current assessment, but only for individuals high in positive schizotypy. The results are consistent with models linking stress sensitivity with the experience of psychotic symptoms. The findings provide cross-cultural support for the multidimensional model of schizotypy and schizophrenia. Furthermore, the findings demonstrate that ESM is an effective method for predicting the experience of psychotic-like symptoms, as well as their precursors, in daily life.

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Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample

Cited by 18 publications

References 57 publications

Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period

Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period

Testing Measurement Invariance of the Schizotypal Personality Questionnaire-Brief Scores across Spanish and Swiss Adolescents

Psychometric schizotypy predicts psychotic-like, paranoid, and negative symptoms in daily life.

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