Childhood infections and risk of wheezing and allergic sensitisation at age 7?8 years

Mommers, Monique; Swaen, Gerard M. H.; Weishoff-Houben, Michaela; Creemers, H.; Freund, Hermann; Dott, Wolfgang; Schayck, C.P. van

doi:10.1007/s10654-004-6016-7

Cited by 15 publications

(21 citation statements)

References 29 publications

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“…5 Several epidemiological studies showed that infectious diseases early in life lead to decreased allergic diseases later in life (the "hygiene hypothesis"), 36,37 although other studies did not confirm this finding. [38][39][40] In line with the latter studies, the lower incidence of infectious diseases in the neonatal period in our study was not associated with a higher rate but in fact with a lower rate of allergic diseases later in life.…”

Section: Commentsupporting

confidence: 91%

Glutamine-Enriched Enteral Nutrition in Very Low-Birth-Weight Infants

Berg¹,

Zwol²,

Moll³

et al. 2007

Arch Pediatr Adolesc Med

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Objective: To determine the effect of glutamineenriched enteral nutrition in very low-birth-weight infants on the incidence of allergic and infectious diseases during the first year of life.Design: Follow-up study.Setting: Tertiary care hospital.Participants: All surviving infants who participated in a trial of glutamine-enriched enteral nutrition in very lowbirth-weight infants.Intervention: Enteral glutamine supplementation (L-glutamine, 0.3 g/kg per day) from 3 through 30 days of life. Main Outcome Measures:The incidence of allergic and infectious diseases during the first year of life, as assessed by means of validated questionnaires.Results: Seventy-seven of 90 infants (86%) participated in the follow-up study. Baseline patient, maternal, and environmental characteristics did not differ between the glutamine-supplemented (n=37) and control (n=40) groups, except for the incidence of serious neonatal infections and child care attendance. After adjustment for confounding factors, the risk for atopic dermatitis was lower in the glutamine-supplemented group (odds ratio [OR], 0.13; 95% confidence interval [CI], 0.02-0.97). However, the incidence of bronchial hyperreactivity (OR, 0.34; 95% CI, 0.10-1.21) and infections of the upper respiratory (OR, 0.99; 95% CI, 0.35-2.79), lower respiratory (OR, 0.39; 95% CI, 0.13-1.24), and gastrointestinal (OR 1.25, 95% CI 0.23-6.86) tracts was not different between the treatment groups.Conclusions: Glutamine-enriched enteral nutrition in very low-birth-weight infants decreased the incidence of atopic dermatitis during the first year of life but had no effect on the incidence of bronchial hyperreactivity and infectious diseases during the first year of life.

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Section: Commentsupporting

confidence: 91%

Glutamine-Enriched Enteral Nutrition in Very Low-Birth-Weight Infants

Berg¹,

Zwol²,

Moll³

et al. 2007

Arch Pediatr Adolesc Med

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“…Since the postulation of the ''hygiene hypothesis'' by Strachan (1), many studies have focused on the relation between daycare and the development of asthma. Studies investigating the association between reported respiratory infections in early life and development of asthma consistently found no protective effect on asthma (5,(10)(11)(12)(13)(14)(15)27). We studied the effect of daycare, which is a proxy for infections (2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…However, convincing evidence that daycare is indeed associated with a reduction in asthma/ allergy in the long term is lacking (6)(7)(8)(9)(10). The fact that multiple studies reported an increased risk of asthma in children with infections in early childhood further adds to the controversy (10)(11)(12)(13)(14)(15).…”

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confidence: 99%