Chickenpox in childhood is associated with decreased atopic disorders, IgE, allergic sensitization, and leukocyte subsets

Silverberg, Jonathan I.; Kleiman, Edward; Silverberg, Nanette B.; Durkin, Helen G.; Joks, Rauno; Smith‐Norowitz, Tamar A.

doi:10.1111/j.1399-3038.2011.01224.x

Cited by 24 publications

(20 citation statements)

References 26 publications

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“…Unconditional logistic regression models were used to calculate odds ratios and 95% confidence intervals (CI) for the associations between glioma status and regular oral antihistamine use, adjusting for potential confounders (which were chosen a priori ). History of chickenpox was included in our models as a potential confounder because a growing body of literature indicates that varicella-zoster exposure may be relevant to glioma risk [32–35] and may also potentially impact the risk for atopic conditions [36, 37]. The regression models were run both among the overall study population and stratified by self-reported allergy/asthma status, as antihistamines are sometimes taken regularly for indications other than allergic conditions (i.e., as sleep aids or antiemetics).…”

Section: Methodsmentioning

confidence: 99%

Antihistamine use and immunoglobulin E levels in glioma risk and prognosis

Amirian

Marquez-Do

Bondy

et al. 2013

Cancer Epidemiology

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Objective An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods We used a subset of the Harris County Case-Control Study, which included 362 pathologically-confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.

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Section: Methodsmentioning

confidence: 99%

Antihistamine use and immunoglobulin E levels in glioma risk and prognosis

Amirian

Marquez-Do

Bondy

et al. 2013

Cancer Epidemiology

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“…Several different pathogens have been suggested to have a protective role against AD and atopy in general, including bacterial endotoxins, helminthes, herpesviridae, farm animals, dogs, unpasteurized milk, and the abundant infectious exposures of early day care [70][71][72][73][74]. Silverberg et al found that a single episode of wild-type varicellazoster virus (chickenpox) infection in the first 8-10 years of life was inversely associated with subsequently developing AD [73], as well as long-term decreased serum IgE levels, peripheral blood lymphocyte, monocyte, and basophil counts [75].…”

Section: Hygiene Hypothesismentioning

confidence: 99%

“…While herpesvirus infections early in life may help prevent AD, infections with herpes simplex and Coxsackie virus in patients with established AD can lead to eczema herpeticum and Coxsakium, respectively [136,137]. Moreover, some studies found that infections with respiratory syncytial virus may actually increase the risk of disease [73,[75][76][77][78]. Finally, it is well established that patients with AD have increased colonization of both lesional and nonlesional skin with Staphylococcal aureus and decreased microbial diversity [79][80][81][82].…”

Section: Hygiene Hypothesismentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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“…We previously reported that exposure to varicella zoster virus in early childhood was associated with lower odds of developing AD, 10 asthma, and hay fever, as well as decreased serum IgE, allergic sensitization, and persistent alterations of leukocyte subsets. 11 It would be expected that immigrants to the United States from developing countries, where infectious stimuli are more prevalent, would have a lower risk of allergic disease.…”

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confidence: 99%