Prevalence of Allergic Disease in Foreign-Born American Children

Silverberg, Jonathan I.; Simpson, Eric L.; Durkin, Helen G.; Joks, Rauno

doi:10.1001/jamapediatrics.2013.1319

Cited by 74 publications

(54 citation statements)

References 28 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study found that children born outside the United States had dramatically lower odds of AD and allergic disease than those born in the United States [135]. One potential explanation is that less hygienic environmental exposures protect against developing AD and allergic disease.…”

Section: Hygiene Hypothesismentioning

confidence: 96%

See 1 more Smart Citation

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

Self Cite

260

225

View full text Add to dashboard Cite

Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

show abstract

Section: Hygiene Hypothesismentioning

confidence: 96%

“…One potential explanation is that less hygienic environmental exposures protect against developing AD and allergic disease. However, the odds of AD increased after residing in the United States for 10 or more years [135]. This suggests that the protective effects of early life exposures may eventually wear off.…”

Section: Hygiene Hypothesismentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

Self Cite

260

225

View full text Add to dashboard Cite

show abstract

“…4,5 The prevalence among recent immigrants is at the same scale as those reported for China and India, 3,16,17 major source countries of immigrants to Canada in recent decades. 18 Previous studies in other countries have also found a lower prevalence of allergies in immigrants compared with nonimmigrants, [19][20][21] and that longer duration of residence in the host country was associated with a higher prevalence of allergies among immigrants. 21,22 However, other studies have also reported null associations 23,24 or a higher prevalence of allergies among immigrants than non-immigrants.…”

Section: Discussionmentioning

confidence: 92%

“…18 Previous studies in other countries have also found a lower prevalence of allergies in immigrants compared with nonimmigrants, [19][20][21] and that longer duration of residence in the host country was associated with a higher prevalence of allergies among immigrants. 21,22 However, other studies have also reported null associations 23,24 or a higher prevalence of allergies among immigrants than non-immigrants. 25 Several factors may contribute to the inconsistency in research.…”

Section: Discussionmentioning

confidence: 92%

Prevalence of non-food allergies among non-immigrants, long-time immigrants and recent immigrants in Canada

Yao

Sbihi

2016

Can J Public Health

View full text Add to dashboard Cite

OBJECTIVES: The prevalence of allergic conditions has been increasing worldwide, with the highest rates seen in Western countries like Canada. The development of allergies is known to be related to both genetic and environmental factors, but the causal pathways remain unclear. Studies on immigrants provide a unique opportunity to disentangle these two factors and provide a better understanding of the disease aetiology. The aim of this study was to investigate the relationship between immigration status and prevalence of non-food allergies in a population-based study of Canadians. RESULTS:The highest prevalence of non-food allergies was found among non-immigrants (29.6%), followed by long-time immigrants (23.9%) and then recent immigrants (14.3%). The odds of non-food allergies were reduced by 60% (OR = 0.40, 95% CI: 0.35, 0.45) among recent immigrants and 25% (OR = 0.75, 95% CI: 0.70, 0.80) among long-time immigrants, compared with non-immigrants, after adjusting for sex, age, socio-economic status and rurality.CONCLUSION: This study finds a distinctly lower prevalence of non-food allergies among immigrants compared with non-immigrants, with the difference diminishing with longer duration of residence in Canada. The findings highlight the potential of environmental determinants of allergy development that warrant further investigation, and demonstrate the need for multicultural strategies to manage the public health burden of allergic conditions. KEY WORDS: Allergy and immunology; respiratory hypersensitivity; emigrants and immigrants; socio-economic factors La traduction du résumé se trouve à la fin de l'article.

show abstract

“…3 This suggests that 1 or more exposures in non-Westernized or developing countries may protect against chronic disease. Indeed, a previous study 4 found that foreign-born American children had dramatically lower prevalence of eczema and allergic disease than USborn American children. Furthermore, low prevalence of vitiligo (0.18%) has been reported in children in the Sinai Desert, suggesting a possible role for latitude in the development of the disease.…”

mentioning

confidence: 96%

Regional Variation of and Association of US Birthplace With Vitiligo Extent

2014

Self Cite

View full text Add to dashboard Cite

IMPORTANCELittle is known about population-based risk factors and regional differences for vitiligo.OBJECTIVE To determine the impact of place of birth and residence on vitiligo extent. DESIGN, SETTING, AND PARTICIPANTSA prospective questionnaire-based study using an online questionnaire with 2786 adults (72.2% of whom resided in the United States) with a history of physician-diagnosed vitiligo. EXPOSURES Regions of birth and residence.MAIN OUTCOMES AND MEASURES Body surface area (BSA) of vitiligo lesions. RESULTSPatients with vitiligo who were born outside the United States had lower odds of vitiligo-affected BSA greater than 25%, even after controlling for race/ethnicity, sex, and current age (logistic regression; adjusted odds ratio [aOR], 0.57 [95% CI, 0.46-0.60]). Birthplace in all continents was associated with lower odds of affected BSA greater than 25% than was birthplace in North America. Adults born outside the United States had less affected BSA whether they resided inside (aOR, 0.58 [96% CI, 0.41-0.81]) or outside the United States (aOR, 0.60 [95% CI, 0.48-0.76]). Birthplace and residence at latitudes closer to the equator were associated with lower rates of affected BSA greater than 25% (P Յ .002). The prevalence of affected BSA greater than 25% varied greatly by state of residence (range, 27.3% in Maryland to 100% in North Dakota, South Dakota, and Wyoming) (global Moran index = 0.37; P < .001; G statistic = 0.62; P < .001). Spatial regression models that controlled for the regional variation were constructed and confirmed that birthplace outside the United States was associated with lower odds of affected BSA greater than 25% (aOR, 0.61 [95% CI,.83]) but not race/ethnicity. CONCLUSIONS AND RELEVANCE There was significant statewide and intercontinental variation for rates of extensive vitiligo. These results suggest that previously unrecognized regional environmental risk factors, especially early in life, play an important role in vitiligo. Additional studies are needed to confirm these early findings and identify such risk factors.TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01401374

show abstract

Prevalence of Allergic Disease in Foreign-Born American Children

Abstract: Children born outside the United States have a lower prevalence allergic disease that increases after residing in the United States for 1 decade.

Cited by 74 publications

References 28 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Prevalence of non-food allergies among non-immigrants, long-time immigrants and recent immigrants in Canada

Regional Variation of and Association of US Birthplace With Vitiligo Extent

Contact Info

Product

Resources

About