Childhood brucellosis: Review of 317 cases

Bosilkovski, Mile; Krteva, Ljiljana; Caparoska, Sonja; Labacevski, Nikola; Petrovski, Mile

doi:10.1016/j.apjtm.2015.11.009

Cited by 31 publications

(33 citation statements)

References 40 publications

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“…In Saudi Arabia, children were reported to have constituted for 21% (115/545) of the total cases of brucellosis, and unpasteurized milk was identified as the main source of infection [126]. In Macedonia, childhood brucellosis (18.8%, 317/1691) was characterized by various organ involvements and a wide spectrum of clinical manifestations [127]. Therefore, given the widespread raw milk consuming habit, it is reasonable to assume that a significant proportion of Ethiopian children, mainly of pastoral origin, could be seroreactors.…”

Section: Resultsmentioning

confidence: 99%

Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis

Tadesse

2016

PLoS Negl Trop Dis

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BackgroundThe objectives of this study were to assess the heterogeneities of estimates and to estimate the seroprevalence of brucellosis in animals and humans in Ethiopia.Methods/Principal findingsData from 70 studies covering 75879 animals and 2223 humans were extracted. Rose Bengal Plate Test (RBPT) and Complement Fixation Test (CFT) in series were the most frequently used serological tests. A random effects model was used to calculate pooled prevalence estimates. The overall True Prevalence of brucellosis seropositivity in goats and sheep were estimated at 5.3% (95%CI = 3.5, 7.5) and 2.7% (95%CI = 1.8, 3.4), respectively, and 2.9% for each of camels and cattle. The prevalence was higher in post-pubertal than in pre-pubertal animals (OR = 3.1, 95% CI = 2.6, 3.7) and in the pastoral than in the mixed crop-livestock production system (OR = 2.8, 95%CI = 2.5, 3.2). The incidence rates of brucellosis in humans of pastoral and sedentary system origins were estimated at 160 and 28 per 100 000 person years, respectively.ConclusionsThe seroprevalence of brucellosis is higher in goats than in other species. Its occurrence is evocative of its importance in the country in general and in the pastoral system in particular. Public awareness creation could reduce the transmission of Brucella spp. from animals to humans and the potential of livestock vaccination as a means of control of brucellosis needs to be assessed.

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Section: Resultsmentioning

confidence: 99%

Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis

Tadesse

2016

PLoS Negl Trop Dis

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“…An El-Koumi MA et al study (9) reported excessive sweating (68%), bone aches (62%), chills (55%), arthritis (32%), hepatomegaly (18%) and splenomegaly (15%) as presenting symptoms. Correspondingly, incidence of leucopenia in 38%, anemia in 64%, and thrombocytopenia in 28% of brucellosis candidates in south-western Saudi Arabia was reported by Dr. Benjamin Annobil (13). The study of Al Shaalan M et al (6) showed that arthritis was prevalent in 70% of patients, 20% of patients presented with a non-specific febrile illness without localizing signs, and 10% had a febrile illness with uncommon presentations.…”

Section: Discussionmentioning

confidence: 78%

Pattern of childhood brucellosis in Najran, south Saudi Arabia in 2013-2017

Hashan¹,

El-Fetoh²,

Nasser³

et al. 2017

Electron Physician

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BackgroundWith more than 500,000 new cases annually, human brucellosis is the commonest zoonotic disease worldwide. In some endemic countries, its prevalence is more than 10 per 100,000 population.ObjectiveThe aim of this study was to determine the magnitude of the problem and the clinical features, laboratory findings, treatment given and complications seen in children with brucellosis in Najran City, Kingdom of Saudi Arabia.MethodsThis is a case-series study by analysis of data of children known or diagnosed to have brucellosis for the last 4 years in Najran City. Data was obtained by reviewing the hospital records of the Maternity and Children Hospital and Najran Armed Forces Hospital in Najran during the period from 2013 to 2017. The statistical analysis was carried out using SPSS version 16.0. Since it was the first report of brucellosis on the study population, we used descriptive statistics (frequency, proportion, mean, and standard deviation) for presenting the findings.ResultsWe studied 57 diagnosed cases of child brucellosis throughout the past 4 years in Najran, south Saudi Arabia with an average number of about 12 cases per year. Of the cases, 15.8% reported a history of ingestion of raw milk and dairy product and only 1.8% of them reported a history of animal contact while 82.4% confirmed unknown mode of transmission. Fever was the only finding in 36.8%, fever and arthralgia 21.1%, and fever and myalgia 19.3%. Two thirds of the cases were diagnosed by standard agglutination test (SAT). Hepatosplenomegaly was found in 10.5%. Rifampicin was the antibiotic of choice and 70.2% of cases have been cured but 3.5% relapsed and 1.8% died from complications.ConclusionsResults suggest brucellosis be considered in every child living in an endemic area, showing symptoms of fever and having a history of ingestion of raw milk and dairy product and/or animal contact.Prevention should rely on health education of the public about different issues of the disease including boiling raw milk.

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“…It has been reported that Brucella infection is mostly observed in the group aged 15-35 years in the endemic regions. Brucella infection was more frequent in children under 14 years of age [8]. The median age of the patients in our study was 10.6, and 85.1% of the patients were children under the age of 14.…”

Section: Discussionmentioning

confidence: 46%

Brucella infection in children: Evaluation of 148 pediatric patients

2019

Ann Clin Anal Med

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Aim: Brucellosis a worldwide infectious zoonotic disease. This study was aimed to evaluate the clinical, demographic characteristics, complications, treatment and follow-up results of pediatric patients diagnosed with brucellosis. Material and Method: The medical records of 148 pediatric patients who were diagnosed with brucellosis were studied retrospectively. Results: Sixty-one female (41.2%), 87 male (58.8%), in total 148 pediatric patients who were diagnosed with brucellosis were included in the study. Among the patients, 64.1% had a history of consuming fresh cheese, 4.1% had a history of consuming raw milk and 16.9% had a history of keeping a Brucella diagnosed animal at home. Brucella history rate in the family members of the patients was determined as 39.2%; and 12.8% of the patients included in the study were asymptomatic. The most common complaint of the patients who were symptomatic was fever (59.5%) followed by arthralgias (41.2%) and leg pain (38.5%). All patients were subjected to standard tube agglutination test and blood culture was taken from 93 patients. B. melitensis in blood culture was positive in 72% of the patients. Osteoarticular involvement developed in 12.1% of the patients; and 1.3% of the patients developed relapses after the end of the treatment. Discussion: Brucellosis is still an endemic disease in Turkey. Brucella can infect all organs and tissues and is a major cause of morbidity. The use of more than one antibiotic in the treatment and long treatment duration reduces patient compliance; thus, close follow-up of the patients is important.

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Childhood brucellosis: Review of 317 cases

Cited by 31 publications

References 40 publications

Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis

Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis

Pattern of childhood brucellosis in Najran, south Saudi Arabia in 2013-2017

Brucella infection in children: Evaluation of 148 pediatric patients

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