Childhood behavior problems and bipolar disorder — relationship or coincidence?

Carlson, Gabrielle A.; Weintraub, Sheldon

doi:10.1016/0165-0327(93)90100-x

Cited by 135 publications

(72 citation statements)

References 23 publications

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“…Evidence from longitudinal studies suggests that early dysregulation of behavior and mood precedes onset of bipolar disorder (Akiskal et al 1995;Carlson and Weintraub 1993;Egeland et al 2003;Kovacs et al 1994) and may in some cases represent the early manifestations of bipolar disorder in children. For example, Carlson and Weintraub (1993) found that children at risk for bipolar disorder had elevated rates of mild to moderate attentional and disruptive behavioral problems at ages 7-16 compared with offspring of controls, and that these problems predicted later affective symptoms. In a test of the hypothesis linking BD to risk for bipolar disorder, we found that children from the present sample whose parents had bipolar disorder had significantly elevated rates of BD (Hirshfeld-Becker et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidence implicates comorbid mood and behavior disorders or their symptoms as precursors to bipolar disorder (Biederman et al 2000b). ADHD, ODD, conduct disorder, and mood disorders have been observed in the histories of both adults (Sachs et al 1994) and children (Biederman et al 1999;Biederman et al 2000a;Faedda et al 1995;Geller et al 2002;Kessler et al 2001;Wozniak and Biederman 1995;Wozniak et al 2001) with bipolar disorder, as well as in offspring at risk for bipolar disorder (Carlson and Weintraub 1993;Chang et al 2000;Cytryn et al 1982;DelBello and Geller 2001;Duffy et al 2000;Grigoroiu-Serbanescu et al 1989;Radke-Yarrow et al 1992;Zahn-Waxler et al 1988). Evidence from longitudinal studies suggests that early dysregulation of behavior and mood precedes onset of bipolar disorder (Akiskal et al 1995;Carlson and Weintraub 1993;Egeland et al 2003;Kovacs et al 1994) and may in some cases represent the early manifestations of bipolar disorder in children.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Outcomes of Laboratory-Observed Preschool Behavioral Disinhibition at Five-Year Follow-up

Hirshfeld‐Becker

Biederman

Henin

et al. 2007

Biological Psychiatry

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Objective-"Behavioral disinhibition" refers to a temperamental tendency to exhibit boldness, approach, and spontaneity in unfamiliar situations. We previously found it to be associated with childhood disruptive behavior and mood disorders as well as with parental bipolar disorder. In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool-age among offspring at risk for anxiety and mood disorders.Method-The sample consisted of 284 children including offspring of parents with panic disorder or major depression and comparison offspring of parents without these disorders, who had been assessed with laboratory observations of temperament at ages 21 months-6 years. We reassessed 215 of the children (77%) at 5-year follow-up (mean age 9.6 years) with structured diagnostic interviews.Results-Compared with non-inhibited, non-disinhibited controls, behaviorally disinhibited children had higher lifetime rates of comorbid mood plus disruptive behavior disorders, and higher current rates of any disruptive behavior disorder and of oppositional defiant disorder.Conclusion-Behavioral disinhibition appears to be a temperamental antecedent of disruptive behavior disorders and their comorbidity with mood disorders in middle childhood, which may be targeted for preventive intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes of Laboratory-Observed Preschool Behavioral Disinhibition at Five-Year Follow-up

Hirshfeld‐Becker

Biederman

Henin

et al. 2007

Biological Psychiatry

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“…A meta-analysis of studies conducted before 1997 found that offspring of bipolar parents were at 2.7 times higher risk for development of any psychiatric disorder and 4 times higher risk for developing a mood disorder than children of parents without psychiatric illness (LaPalme, Hodgins, & LaRoche, 1997). Between 50% and 60% of the offspring of BD parents have some type of psychiatric disorder, especially mood, anxiety, and disruptive behavior disorders (Carlson & Weintraub, 1993;Chang et al, 2000;Wals et al, 2005).…”

Section: Evidence For Mood and Behavior Disturbance In At-risk Childrenmentioning

confidence: 99%

Prevention of bipolar disorder in at-risk children: Theoretical assumptions and empirical foundations

Miklowitz

Chang

2008

Dev Psychopathol

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This article examines how bipolar symptoms emerge during development, and the potential role of psychosocial and pharmacological interventions in the prevention of the onset of the disorder. Early signs of bipolarity can be observed among children of bipolar parents and often take the form of subsyndromal presentations (e.g., mood lability, episodic elation or irritability, depression, inattention, and psychosocial impairment). However, many of these early presentations are diagnostically nonspecific. The few studies that have followed at-risk youth into adulthood find developmental discontinuities from childhood to adulthood. Biological markers (e.g., amygdalar volume) may ultimately increase our accuracy in identifying children who later develop bipolar I disorder, but few such markers have been identified. Stress, in the form of childhood adversity or highly conflictual families, is not a diagnostically-specific causal agent but does place genetically and biologically vulnerable individuals at risk for a more pernicious course of illness. A preventative family-focused treatment for children with (a) at least one first-degree relative with bipolar disorder, and (b) subsyndromal signs of bipolar disorder, is described. This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder.

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“…Lapalme et al (1997) reported that the psychosocial effects of developing bipolar disorder in parents besides genetic predisposition can double the risk of developing mental disorders and behavioral problems in their children (8). Furthermore, Carlson and Weintraub (1993) stated that high rates of behavioral problems and attention problems in children of patients with bipolar disorder are predictors of mood disorders in the future. Therefore, the symptoms can be debilitating for the patient and destructive to the family.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the symptoms can be debilitating for the patient and destructive to the family. Hence, identifying these symptoms can help diagnose and treat these people and prevent development of mood disorders, particularly bipolar disorder (9). Reichart et al (2001) reported that girls and boys of parents with bipolar disorder suffer from extensive behavioral problems compared to normal subjects (10).…”

Section: Introductionmentioning

confidence: 99%

Comparing Mental Health of School-Age Children of Parents With/Without Bipolar Disorders: A Case Control Study

Shamsaei¹,

Cheraghi²,

Dehghani³

et al. 2015

Avicenna J Neuro Psycho Physiology

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Background: Children of parents with bipolar disorder appear to have an increased risk of early-onset Bipolar Disorder (BP), mood disorders and other psychiatric disorders. Objectives: The aim of this study was to compare the mental health of school-age children of parents, with/without bipolar disorder. Materials and Methods: This case-control study included one hundred children aged six to twelve years, who had parents with bipolar disorder and 200 children of 163 demographically-matched control parents. Parents with bipolar disorder were recruited from Farshchian Psychiatric Hospital of Hamadan, Iran, during year 2014. The parent version of the Child Symptom Inventory-4 questionnaire was used to measure mental health. Mean comparisons were performed using Student's t test while effect sizes were estimated by Cohen's d coefficient. The Chi-square test was used to assess significant differences between frequency distribution of demographic variables in both groups. The significance level was considered less than 0.05. Results: There were statistically significant differences between children of parents with and those without bipolar disorder regarding attention deficit hyperactivity disorder, oppositional defiant disorder, conduct, generalized anxiety disorder, schizophrenia, major depression, separation anxiety (P< 0.001) and social phobia (P < 0.05). Children of parents with BP are at high risk for psychiatric disorders. Conclusions: These findings support that the careful evaluation and prospective following of the psychopathology of children of parents with bipolar disorder are critical for early identification and treatment.

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Childhood behavior problems and bipolar disorder — relationship or coincidence?

Cited by 135 publications

References 23 publications

Clinical Outcomes of Laboratory-Observed Preschool Behavioral Disinhibition at Five-Year Follow-up

Clinical Outcomes of Laboratory-Observed Preschool Behavioral Disinhibition at Five-Year Follow-up

Prevention of bipolar disorder in at-risk children: Theoretical assumptions and empirical foundations

Comparing Mental Health of School-Age Children of Parents With/Without Bipolar Disorders: A Case Control Study

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