Childhood Absence Epilepsy in Patients With Benign Focal Epileptiform Discharges

Sarkis, Rani A.; Loddenkemper, Tobias; Burgess, Richard C.

doi:10.1016/j.pediatrneurol.2009.07.004

Cited by 11 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 2 also illustrates the percentage of patients who demonstrated complete elimination of the SWCs in EEGs six months after initiation of the D treatment. In group 1 in general, the number of such successful cases made up 63.9%; this figure agrees with the data reported by other authors [12][13][14]. It seems that the best results (69.6%) were observed in patients of subgroup B (in which EEG SWC bursts arose only against HpV), but the difference from subgroup A in this respect is probably insignificant.…”

Section: Efficacy Of Treatment In Group 1 the Analysis Of Results Ofsupporting

confidence: 89%

See 1 more Smart Citation

Comparative Efficacy of Pharmacological Treatment of Absence Epilepsy with Typical and Deviating (Complex) EEG Patterns

2016

View full text Add to dashboard Cite

In a group of 96 children and teenagers suffering from absence epilepsy, we compared the efficacy of treatment with a valproic acid derivative, Depakin (D). In 72 patients of group 1, EEGs contained bursts of typical absence seizure phenomena, generalized 3-4 Hz spike/wave complexes, SWCs. In 24 patients of group 2, these EEG phenomena were combined with other types of epileptiform elements (generalized and focal irregular peak/wave complexes, single and grouped sharp waves, spikes, polyspikes, etc.). It was found that pharmacotherapy with D effectively eliminated SWCs generated in the resting state of the patients; epileptiform phenomena provoked by hyperventilation and rhythmic photostimulation were noticeably more resistant from this aspect. The efficacy of treatment with D was considerably higher in group 1 (patients with the EEG patterns including only SWCs) than in group 2 (patients with deviating EEG patterns containing, together with SWCs, epileptiform elements of other types). Six months after the D therapy initiation, complete elimination of typical 3-4 Hz SWCs was observed in 63.9% of group-1 patients and in 41.7% of group-2 patients.

show abstract

Section: Efficacy Of Treatment In Group 1 the Analysis Of Results Ofsupporting

confidence: 89%

“…According to the ILAE recommendations, a firstline choice for the treatment of TASs is valproic acid and its derivatives [12]. The existence of absence epilepsy cases with dissimilar EEG patterns should, apparently, be taken into consideration when selecting an adequate strategy of treatment.…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Pharmacological Treatment of Absence Epilepsy with Typical and Deviating (Complex) EEG Patterns

2016

View full text Add to dashboard Cite

show abstract

“…Dep therapy decreased Beta activity in the parieto-occipital lobes, the regions where its presence is conventionally accounted for the CNS regulatory mechanisms dysfunction [31] Dep suppresses the first of the typical epileptiform complexes SW 3/s which is characteristic for absence epilepsy generated by thalamo-cortical structures. This effect was observed as early as 3 months after the beginning of the treatment and Dep was evaluated as successful at complete elimination of epileptiform elements in EEG [32,33,34] Dep reveals of less effect on the irregular single spike-waves complexes, sharp waves, spikes-polyspikes and as well as on generalized paroxysmal bursts provoked by functional trials, and Dep was not considered as fully successful. These cases reflect the certain specificity of epileptogenesis [35,36].…”

Section: Quantitative Eeg Evaluation During Dep Treatmentmentioning

confidence: 99%

The investigation of EEG specificity in epileptic children during Depakine therapy

Khachidze

Gugushvili²,

Makashvili

et al. 2015

International Journal of Neuroscience

View full text Add to dashboard Cite

The findings of this study suggest that the presence of RMT with tempo-parietal localization on the interictal EEG can anticipate reocurrence of seizures if Dep dose will be reduced or withdrawn. The efficacy of the AED therapy can be revealed via reduction of low-frequency waves and suppression of epileptiform EEG elements parallel to clinical improvement. Thus, optimal treatment strategies can be tailored based on the evaluation of background EEG characteristics using spectral analysis, EEG mapping, and the quantitative EEG approach.

show abstract

“…The EEG seizure pattern originates most frequently from the centrotemporal region although parietal origins have also been reported (Saint-Martin et al, 2001), and the epileptiform activity frequently spreads to involve one hemisphere or the whole brain (Fig. Postictal slowing is usually not prolonged (Bernardina and Tassinari, 1975;Saint-Martin et al, 2001;Sarkis et al, 2009;Wirrell, 1998). Postictal slowing is usually not prolonged (Bernardina and Tassinari, 1975;Saint-Martin et al, 2001;Sarkis et al, 2009;Wirrell, 1998).…”

Section: Electroencephalogram Featuresmentioning

confidence: 99%

“…Modified with permission from Elsevier Publishers: Pediatric Neurology(Sarkis et al, 2009(Sarkis et al, ), copyright (2009. Seizure onset A, and evolution B, in the left centrotemporal region.…”

mentioning

confidence: 99%

Pediatric Focal Epilepsy Syndromes

Fernández

Loddenkemper

2012

Journal of Clinical Neurophysiology

Self Cite

View full text Add to dashboard Cite

Benign epilepsy with centrotemporal spikes, early-onset childhood occipital epilepsy (Panayiotopoulos syndrome [PS]) and late-onset childhood occipital epilepsy (Gastaut type [LOCE-G]) are the principal pediatric focal epilepsy syndromes. They share major common characteristics: the appearance and resolution of electroclinical features are age related, there is a strong genetic predisposition, the clinical course is often mild with infrequent and easy to control seizures, interictal epileptiform activity is disproportionately abundant when compared with the clinical correlate, and tends to potentiate and generalize during sleep. In this review, we outline the relevant pathophysiology underlying this electroclinical spectrum. Then, the initial description of individual syndromes is followed by a summary of overlapping features and intermediate presentations that question the boundaries between these entities and provide the basis for the concept of a childhood seizure susceptibility syndrome. Additionally, we outline the main features of the related epileptic encephalopathies. An outlook on potential future lines of research completes this review.

show abstract

Childhood Absence Epilepsy in Patients With Benign Focal Epileptiform Discharges

Cited by 11 publications

References 34 publications

Comparative Efficacy of Pharmacological Treatment of Absence Epilepsy with Typical and Deviating (Complex) EEG Patterns

Comparative Efficacy of Pharmacological Treatment of Absence Epilepsy with Typical and Deviating (Complex) EEG Patterns

The investigation of EEG specificity in epileptic children during Depakine therapy

Pediatric Focal Epilepsy Syndromes

Contact Info

Product

Resources

About