Chikungunya Virus Infection Outcome: A Systematic Review of Host Genetics

Ferreira, Jean Moisés; Santos, Leandro Douglas Silva; Oliveira, Susana Paiva; Santos, Bárbara Rayssa Correia dos; Santos, Ana Caroline Melo dos; Souza, Elaine V.M.; Filho, José Luiz de Lima

doi:10.1080/08820139.2020.1733011

Cited by 4 publications

(3 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one CHIKV isolate was used to represent each of the two genotypes, and more clinical strains should be studied. More immune analytes should be included in future work, such as IL-7, IL-15, IL-27, TGF-β, eotaxin, HGF, and Mxra8 receptor, which have all been associated with CHIKV severity [54].…”

Section: Discussionmentioning

confidence: 99%

Replication and innate immune responses of two chikungunya virus genotypes in human monocyte-derived macrophages

Lau

Chua

Chan

et al. 2023

Journal of General Virology

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus, which causes epidemics of fever, joint pain and rash. There are three genotypes: West African, East/Central/South/Africa (ECSA) and Asian, with the latter two predominant globally. Genotype-specific differences in clinical presentations, virulence and immunopathology have been described. Macrophages are key cells in immune responses against CHIKV. Circulating blood monocytes enter tissue to differentiate into monocyte-derived macrophages (MDMs) in response to CHIKV infection at key replication sites such as lymphoid organs and joints. This study analyses differences in replication and induced immune mediators following infection of MDMs with Asian and ECSA CHIKV genotypes. Primary human MDMs were derived from residual blood donations. Replication of Asian (MY/06/37348) or ECSA (MY/08/065) genotype strains of CHIKV in MDMs was measured by plaque assay. Nineteen immune mediators were measured in infected cell supernatants using multiplexed immunoassay or ELISA. MY/08/065 showed significantly higher viral replication at 24 h post-infection (h p.i.) but induced significantly lower expression of proinflammatory cytokines (CCL-2, CCL-3, CCL-4, RANTES and CXCL-10) and the anti-inflammatory IL-1Ra compared to MY/06/37348. No differences were seen at later time points up to 72 h p.i. During early infection, MY/08/065 induced lower proinflammatory immune responses in MDMs. In vivo, this may lead to poorer initial control of viral infection, facilitating CHIKV replication and dissemination to other sites such as joints. This may explain the consistent past findings that the ECSA genotype is associated with greater viremia and severity of symptoms than the Asian genotype. Knowledge of CHIKV genotype-specific immunopathogenic mechanisms in human MDMs is important in understanding of clinical epidemiology, biomarkers and therapeutics in areas with co-circulation of different genotypes.

show abstract

Section: Discussionmentioning

confidence: 99%

Replication and innate immune responses of two chikungunya virus genotypes in human monocyte-derived macrophages

Lau

Chua

Chan

et al. 2023

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…In addition, TNFα gene polymorphism was associated with chronic joint pain [ 67 ]. A recent systematic review revealed that DRB1*14 was associated with the susceptibility of symptomatic CHIKV infection [ 69 ]. Since these genes are involved in viral recognition and subsequent antiviral IFN and adaptive immune responses, these associations highlight the importance of the host immune responses in human susceptibility to CHIKV infection and in modulating the disease pathogenesis, as described below.…”

Section: The Viral and Host Factors Involved In The Pathogenesis Of C...mentioning

confidence: 99%

Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development

Hakim¹,

Aman²

2022

Viruses

View full text Add to dashboard Cite

Chikungunya virus, the causative agent of chikungunya fever, is generally characterized by the sudden onset of symptoms, including fever, rash, myalgia, and headache. In some patients, acute chikungunya virus infection progresses to severe and chronic arthralgia that persists for years. Chikungunya infection is more commonly identified in tropical and subtropical regions. However, recent expansions and epidemics in the temperate regions have raised concerns about the future public health impact of chikungunya diseases. Several underlying factors have likely contributed to the recent re-emergence of chikungunya infection, including urbanization, human travel, viral adaptation to mosquito vectors, lack of effective control measures, and the spread of mosquito vectors to new regions. However, the true burden of chikungunya disease is most likely to be underestimated, particularly in developing countries, due to the lack of standard diagnostic assays and clinical manifestations overlapping with those of other endemic viral infections in the regions. Additionally, there have been no chikungunya vaccines available to prevent the infection. Thus, it is important to update our understanding of the immunopathogenesis of chikungunya infection, its clinical manifestations, the diagnosis, and the development of chikungunya vaccines.

show abstract

“…In 2014, CHIKV was responsible for causing a major epidemic in Brazil, mainly affecting the Northeast region ( 4 ). In the Americas alone, about 693,489 suspected cases and 37,480 confirmed cases of CHIK were reported in 2015 ( 5 , 6 ). In 2022, from January until November 23, 2022, a total of 362,021 cases and 77 deaths were reported.…”

Section: Introductionmentioning

confidence: 99%

Influence of host genetic polymorphisms involved in immune response and their role in the development of Chikungunya disease: a review

Gotay,

Rodrigues,

Yaochite

2023

Braz J Med Biol Res

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is transmitted by the bite of infected mosquitoes and can cause significant pathogenicity in humans. Moreover, its importance has increased in the Americas since 2013. The primary vectors for viral delivery are the mosquito species Aedes aegypti and Aedes albopictus . Several factors, including host genetic variations and immune response against CHIKV, influence the outcomes of Chikungunya disease. This work aimed to gather information about different single nucleotide polymorphisms (SNPs) in genes that influence the host immune response during an infection by CHIKV. The viral characteristics, disease epidemiology, clinical manifestations, and immune response against CHIKV are also addressed. The main immune molecules related to this arboviral disease elucidated in this review are TLR3/7/8 , DC-SIGN , HLA-DRB1/HLA-DQB1, TNF, IL1RN, OAS2/3 , and CRP. Advances in knowledge about the genetic basis of the immune response during CHIKV infection are essential for expanding the understanding of disease pathophysiology, providing new genetic markers for prognosis, and identifying molecular targets for the development of new drug treatments.

show abstract

Chikungunya Virus Infection Outcome: A Systematic Review of Host Genetics

Cited by 4 publications

References 90 publications

Replication and innate immune responses of two chikungunya virus genotypes in human monocyte-derived macrophages

Replication and innate immune responses of two chikungunya virus genotypes in human monocyte-derived macrophages

Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development

Influence of host genetic polymorphisms involved in immune response and their role in the development of Chikungunya disease: a review

Contact Info

Product

Resources

About