Chikungunya virus as a trigger for different renal disorders: an exploratory study

Costa, Denise Maria do Nascimento; Machado, Carlos Eduardo; Neves, Precil Diego Miranda de Menezes; Brito, Dyego José de Araújo; Oi, Samira Shizuko Parreão; Barros, Flávio Henrique Soares; Figueiredo, Luíz Tadeu Moraes; Araújo, Stanley Almeida; Ladchumananandasivam, Francisco Rasiah; Reis, Marlene Antônia dos; Luchi, Weverton Machado; Lages, Joyce Santos; Filho, Natalino Salgado; Onuchic, Luiz Fernando; Duarte, Ângela Luzia Branco Pinto; Marques, Cláudia Diniz Lopes; Coêlho, Maria Rosângela Cunha Duarte; Oliveira, Camila Barbosa Lyra de; Vajgel, Gisele; Cavalcante, Maria Alina Gomes de Mattos; Valente, Lucila Maria; Magalhäes, Vera; Silva, Gyl Eanes Barros

doi:10.1007/s40620-022-01256-6

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…The renal histopathological findings described include acute interstitial nephritis with mononuclear infiltrates, glomerular congestion, nephrosclerosis, as well as glomerulopathies, pigment cast nephropathy and thrombotic microangiopathy. [46][47][48][49][50]52 Despite the identification of viral antigen in renal tissue, no evident cytopathic effect was demonstrated. 48,49 There are many case reports of CHIK associated with atypical and severe manifestations such as AKI, with some patients experiencing rapid deterioration and death from multisystem failure.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies with renal biopsies have been performed to date, mostly with patients in the acute phase of CHIK. The renal histopathological findings described include acute interstitial nephritis with mononuclear infiltrates, glomerular congestion, nephrosclerosis, as well as glomerulopathies, pigment cast nephropathy and thrombotic microangiopathy 46–50,52 . Despite the identification of viral antigen in renal tissue, no evident cytopathic effect was demonstrated 48,49 …”

Section: Discussionmentioning

confidence: 99%

“…However, in a more recent study, in vivo kidney samples were obtained from 15 patients with established kidney damage after 15 days to 24 months of CHIK infection (Figure 2). 50 There was a predominance of glomerular lesions, with findings of focal segmental glomerulosclerosis (3), lupus nephritis (3), collapsing glomerulopathy (2), membranous nephropathy (2), crescentic glomerulonephritis (2) and pauci‐immune vasculitis (1) in addition to thrombotic microangiopathy (2). There was no detection of viral material in the kidney tissue in these cases.…”

Section: Acute Kidney Injury Associated With Chikungunya Fevermentioning

confidence: 99%

“…There was no detection of viral material in the kidney tissue in these cases. Due to the demonstration of risk genotypes for kidney lesions in some individuals, the authors hypothesised that CHIKV may have been a trigger for the onset of kidney lesions especially in those genetically susceptible 50 . Two case reports also support this hypothesis, including a case of acute tubular necrosis due to catastrophic fatal antiphospholipid antibody syndrome in a patient with systemic lupus erythematosus and a case of thrombotic microangiopathy due to atypical haemolytic uraemic syndrome in an individual with increased genetic susceptibility for the disease 51,52 …”

Section: Acute Kidney Injury Associated With Chikungunya Fevermentioning

confidence: 99%

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The relationship between chikungunya virus and the kidneys: A scoping review

Costa

Gouveia

Silva

et al. 2022

Reviews in Medical Virology

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Several atypical forms of chikungunya fever (CHIK) have been described, including neurological, cardiac and renal involvement. These forms may be related to high morbidity and mortality rates. This scoping review based on the PubMed, Scopus, and WOS databases aims to identify and summarise all the available evidence regarding the clinical and histopathological presentations and risk factors associated with kidney injury related to CHIK, as well as the clinical impact. Thus, a total of 54 papers were selected from 1606 initial references after applying the defined inclusion criteria. Data on the association between kidney injury and CHIK are scarce, with studies only conducted in the acute phase of the disease, lacking further characterisation. Kidney injury incidence in hospitalised patients using the Kidney Disease Improving Global Outcomes criteria varies from 21% to 45%, being higher among patients with atypical and severe manifestations. Although acute kidney injury does not seem to be related to viraemia, it may be related to higher mortality.Few studies have described the renal histopathological changes in the acute phase of CHIK, with prevalent findings of acute interstitial nephritis with mononuclear infiltrate, glomerular congestion and nephrosclerosis. Only one study assessed the kidney function of patients in the subacute and chronic phases of CHIK. Additionally, individuals with comorbidities, including chronic kidney disease, may be among those with a greater risk of presenting worse outcomes when affected by CHIK. The results described herein may contribute to better understand the relationship between the kidneys and chikungunya virus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Acute Kidney Injury Associated With Chikungunya Fevermentioning

confidence: 99%

Section: Acute Kidney Injury Associated With Chikungunya Fevermentioning

confidence: 99%

See 2 more Smart Citations

The relationship between chikungunya virus and the kidneys: A scoping review

Costa

Gouveia

Silva

et al. 2022

Reviews in Medical Virology

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“…A study in Brazil analyzing patients with biopsy-proven kidney injury established that the most frequent diagnoses were focal and segmental glomerulosclerosis and most were associated with autoimmune phenomena, suggesting that chikungunya is a trigger for auto-immunity 21 .…”

Section: Kidney Involvementmentioning

confidence: 99%

Common arboviruses and the kidney: a review

Aguiar,

Silva Júnior,

Ramalho

et al. 2024

Braz. J. Nephrol.

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Arboviruses are endemic in several countries and represent a worrying public health problem. The most important of these diseases is dengue fever, whose numbers continue to rise and have reached millions of annual cases in Brazil since the last decade. Other arboviruses of public health concern are chikungunya and Zika, both of which have caused recent epidemics, and yellow fever, which has also caused epidemic outbreaks in our country. Like most infectious diseases, arboviruses have the potential to affect the kidneys through several mechanisms. These include the direct action of the viruses, systemic inflammation, hemorrhagic phenomena and other complications, in addition to the toxicity of the drugs used in treatment. In this review article, the epidemiological aspects of the main arboviruses in Brazil and other countries where these diseases are endemic, clinical aspects and the main laboratory changes found, including changes in renal function, are addressed. It also describes how arboviruses behave in kidney transplant patients. The pathophysiological mechanisms of kidney injury associated with arboviruses are described and finally the recommended treatment for each disease and recommendations for kidney support in this context are given.

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Extra-articular Manifestations of Chikungunya

Oliveira,

Nogueira,

Amaral

et al. 2023

Rev. Soc. Bras. Med. Trop.

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Chikungunya fever (CHIK) is a neglected tropical disease associated with chronic arthritis. CHIK is usually a self-limiting condition; however, extra-articular manifestations present as atypical illness in a minority of patients. These atypical features may mimic other conditions and potentially distract physicians from the true diagnosis. This review analyzes the evidence of many unusual extra-articular manifestations reported in cases of CHIK. Depending on the affected system, these unusual manifestations include encephalitis, myocarditis, acute interstitial nephritis, cutaneous manifestations, acute anterior uveitis, abdominal pain, and depression. In addition, coinfections and comorbidities may cause atypical illness and obscure the diagnosis. Further studies are required to clarify the pathophysiology and natural history of CHIK, as it remains a burdening condition. Exploring its atypical symptoms may be the missing scientific piece of this puzzle.

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Chikungunya virus as a trigger for different renal disorders: an exploratory study

Cited by 5 publications

References 27 publications

The relationship between chikungunya virus and the kidneys: A scoping review

The relationship between chikungunya virus and the kidneys: A scoping review

Common arboviruses and the kidney: a review

Extra-articular Manifestations of Chikungunya

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