Chikungunya en las Américas: Preparación, vigilancia y alerta en Chile

Clouet-Huerta, Diego E; Alfaro-Toloza, Patricio; Rodríguez‐Morales, Alfonso J.

doi:10.4067/s0716-10182014000600022

Cited by 17 publications

(9 citation statements)

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“…Because of the Fig. 1 Nonlinear regression model for estimations of the cumulative proportion of patients with pCHIK-CIR over the time (bubble size is relative to each study sample size) highly debilitating nature of CHIK disease and its possible deleterious economic consequences [5], long-term followups (>5 years) should be performed in order to improve disease characterization and distinguish the different disease landscapes and endemic variability for each country as recently suggested by other authors [2,3].…”

Section: Discussionmentioning

confidence: 98%

“…Chikungunya (CHIK) has emerged as a major public health threat in Latin America affecting extensive tropical and temperate areas, where the disease, originally imported to the Caribbean, has now rapidly expanded into new regions to become endemic [1][2][3]. Although classically presenting as an acute febrile syndrome, CHIK is well known to produce severe acute and chronic musculoskeletal manifestations ranging from eruptive polyarthritis to persistent rheumatologic and disabling symptoms [4].…”

Section: Introductionmentioning

confidence: 99%

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How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?

et al. 2015

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Post-chikungunya chronic inflammatory rheumatism (pCHIK-CIR) is one of the consequences that are impacting new endemic countries, such as those in the Americas. The relative frequency of pCHIK-CIR is highly variable, ranging from 14.4 % to 87.2 % (including variable number of patients and follow-up times). Based on those non-weighted values, it is difficult to estimate which would be the expected number of patients with CHIK who will develop CIR. For these reasons, we modeled weighted estimations based on pooled data extracted from those eight representative studies in order to provide cumulative proportion of pCHIK-CIR over time and median time of it, but also estimations of the number of patients with CHIK reported in Latin American countries (within a 95 % CI). This model estimated a prevalence of 47.57 % for pCHIK-CIR (95 % CI 45.08-50.13), with a median time to 50 % of pCHIK-CIR in 20.12 months. Given the reported number of patients with acute CHIK during 2014 in the Americas, our estimates suggest that from those patients, 385,835-429,058 patients will develop pCHIK-CIR. Despite the limitations of these estimates, the provided figures of pCHIK-CIR presented here are preliminary approximations of what the future burden of related rheumatic disease in the region as a consequence of CHIK infection for 2015-2016 could be, given the timeframe of median time of occurrence.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?

et al. 2015

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“…Subsequent infections of Zika virus in other Pacific islands were not reported until 2013 when this virus reappeared in French Polynesia and then disseminated throughout the Pacific [4,6]. In January-February 2014 one Zika case was confirmed in Eastern Islands (Rapa Nui National Park, Chile) in the Pacific ocean [7]; then in May 2015, 17 cases were confirmed in three states of Brazil: Bahia (8 cases), Rio Grande do Norte (8 cases) and São Paulo (1 case) [8].…”

mentioning

confidence: 95%

Zika: the new arbovirus threat for Latin America

Rodríguez-Morales

2015

J Infect Dev Ctries

123

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“…Subsequent infections were not reported until 2013 when this virus reappeared in French Polynesia and then disseminated throughout the Pacific [41,42]. In January to February 2014, one case of zika virus infection was confirmed in Eastern Islands in the Pacific Ocean [61]; then in May 2015, 17 cases were confirmed in three states of Brazil [62]. Infection with the virus has been associated with microcephaly in mothers who have been infected during the 1 st or 2 nd trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 99%