Chicoric acid, a new compound able to enhance insulin release and glucose uptake

Tousch, Didier; Lajoix, Anne‐Dominique; Hosy, Eric; Azay-Milhau, Jacqueline; Ferrare, Karine; Jahannault, C.; Cros, Gérard; Petit, Pierre

doi:10.1016/j.bbrc.2008.09.088

Cited by 137 publications

(111 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…α-Glucosidase inhibition [85]. Insulin-sensitizing and insulin-secreting principles [86]. Neuroprotection by stimulating AChE activity in brains of alloxan diabetic rats [87] Polyphenols and flavonoids: ferulic acid; the chief derivative of hydroxycinnamic acid, rutin, and isorhamnetin derivatives [91].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

View full text Add to dashboard Cite

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

View full text Add to dashboard Cite

“…DC., atraditional chinese medicinal herb, has been used to treat gynecological diseases including menorrhagia, puerperal metrorrhagia, peripheral edema, infertility and vulvar ulcer [1]. Recent research showed that the phenolic compounds are widely present in medicinal plants, exhibiting antioxidant, antivirus, immunomodulatory, antiallergic, and other types of pharmacological activity [2][3][4][5]. Up to now, about 20 phenolic compounds such as caffeic acid, chlorogenic acid and hydroxycinnamic acid have been isolated from Blumea riparia DC.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of (E)-3-(3,4-dihydroxyphenyl)-N-ethylacrylamide, C11H13NO3, a caffeic acid imide

Meng¹,

Jiang²,

Wang³

et al. 2011

Zeitschrift Für Kristallographie - New Crystal Structures

View full text Add to dashboard Cite

show abstract

“…L6 rat myocyte cells (LGC Promochem, France) were cultured in 12-well plates as previously described by Tousch et al (2008). Briefly, on the day of the experiment, cells were first starved during 4 h in DMEM supplemented with 0.1% BSA and then incubated during one hour in KRB supplemented with 0.1% BSA, 5 mM glucose in the absence or in the presence of 100 nM insulin.…”

Section: -Glucose Uptake Test On L6 Cellsmentioning

confidence: 99%

“…These two Asteraceas extracts contain a lot of caffeoyl-derivatives. The chicory extract (NCRAE), rich in chicoric acid (dicaffeoyl tartaric acid) has a in vitro ability to increase glucose uptake in L6 muscular cell line (Tousch et al, 2008;Azay-Milhau et al, 2013). Moreover, in vivo experiments by an intraperitoneal glucose tolerance test on normal rats have brought evidence that NCRAE can improve glucose tolerance (Azay-Milhau et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Ferrare

Bidel

Awwad

et al. 2018

Journal of Ethnopharmacology

Self Cite

View full text Add to dashboard Cite

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect, Journal of Ethnopharmacology, https://doi.org/10. 1016/j.jep.2017.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACT Ethnopharmacological relevance Chicory (Cichorium intybus L.) is an indigenous vegetable widely cultivated in Europe,America and Asia. In ancient times, the leaves, flowers, seeds, and roots have been used as a wealth of health benefits including its tonic effects, the ability to ease digestive problems and to detoxify liver. In Indian traditional therapy, chicory was known to possess antidiabetic effect. In the traditional medicine of Bulgaria and Italy, chicory was used as hypoglycemic decoctions. Aims of the studiesWe wanted to obtain the complete chemical composition of the natural chicoric acid extract (NCRAE), a chicory root extract rich in chicoric acid, which previously showed its glucose tolerance effect in normal rats. To investigate if the whole NCRAE is required to be effective, we performed a comparative in vivo experiment on STZ diabetic rats treated either with NCRAE or a mixture composed of the two major compounds of NCRAE. Materials and Methods1 K. Ferrare and L.P.R. Bidel contributed equally to this study. ResultsThe LC-MS analysis confirmed the high abundance of chicoric acid (64.2%) in NCRAE and a second part of NCRAE is composed of caffeoylquinic acids (CQAs) at 19.6% with among them the chlorogenic acid. This result has permitted us to prepare a mixture of synthetic Lchicoric acid (70%) and synthetic chlorogenic acid (30%): the solution is designated SCCAM.Our results showed that both NCRAE and SCCAM are able to improve a glucose tolerance in STZ diabetic rats after a subchronic administration of seven days. Alone NCRAE allows to significantly decrease the basal hyperglycemia after six days of treatment. In vivo experiments on streptozotocin Chicoric acid 72.4 % Caffeoyl-quinic acids 19.6 % NCRAE contained a mixture of CRA, CGA and others caffeoyl derivatives that confer this antidiabetic -NCRAE induced a antidiabetic effect, -SCCAM induced an glucose

show abstract

Chicoric acid, a new compound able to enhance insulin release and glucose uptake

Cited by 137 publications

References 22 publications

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Crystal structure of (E)-3-(3,4-dihydroxyphenyl)-N-ethylacrylamide, C11H13NO3, a caffeic acid imide

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Contact Info

Product

Resources

About