Chicken type II collagen induced immune tolerance of mesenteric lymph node lymphocytes by enhancing beta2-adrenergic receptor desensitization in rats with collagen-induced arthritis

Tolerancia oral en artritis experimental inducida por antígeno en conejos por administración de hidrolizado de cartílago articular

“…También observaron que los animales que lo toleraron redujeron el índice de artritis y elevaron IL-4 y TGF-␤ en bazo y placas de Peyer. Diferentes dosis de CII redujeron significativamente hiperplasia sinovial y el infiltrado linfocitario en ganglios linfáticos mesentéri-cos en ratas con artritis inducida por colágeno 29 . Un trabajo reciente demostró en ratones BALB/c que la administración de CII indujo tolerancia periférica por inducción de linfocitos T reguladores CD8 30 .…”

Expression and function of β-arrestin 2 stimulated by IL-1β in human fibroblast-like synoviocytes and the effect of paeoniflorin

“…β-Arrestin 2-mediated signaling can inhibit constitutive pro-inflammatory signaling in airway epithelial cells and immune cells in asthma [21]. The protein expression of β-arrestins increased in mesenteric lymph node (MLN) lymphocytes of AA and CIA rats in murine models of RA [18,22,23]. Our previous study has found that there were no significant differences in the protein expression of β-arrestin 1, however the expression of β-arrestin 2 of synovial tissue in CIA rats increased apparently [17].…”

Type II Collagen and Gelatin from Silvertip Shark (Carcharhinus albimarginatus) Cartilage: Isolation, Purification, Physicochemical and Antioxidant Properties

“…Oral tolerance is an immunological mechanism by which external agents that enter the body through the digestive system are recognized and ignored by the immune system. The effects of oral administration of type II collagen obtained from bovine, chicken and sheep sources have been evaluated for the treatment of rheumatoid arthritis (RA) [8,9,10]. …”