Expression and function of β-arrestin 2 stimulated by IL-1β in human fibroblast-like synoviocytes and the effect of paeoniflorin

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

“…The radioactivity of [ 3 H]-TdR was measured using a LS6500 liquid scintillation counter (Beckman Coulter, Fullerton, CA). The results are described as the average of triplicate counts per minute [32] .…”

Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by RhIL-1β

“…Another recently published paper revealed that paeoniflorin might suppress human FLS proliferation by inhibiting the expression of β-arrestin 2 and up-regulating cAMP-PKA signaling pathway [54]. Based on the above clues, we will explore the mechanism of paeoniflorin from the change of EP receptor and downstream signaling.…”

Network analysis and transcriptome profiling in peripheral blood mononuclear cells of patients with rheumatoid arthritis

“…The results indicated that for patients with RA, significant changes in their lncRNA expression profile in PBMCs may be related to inflammation. These pathways are related to signaling pathways such as TGF, TNF, EBRr and cAMP, which have been widely confirmed to have an important role in the pathogenesis of RA (30)(31)(32).…”