Chicken skeletal muscle-associated macroarray for gene discovery

Jorge, Érika Cristina; Melo, C. M. R.; Rosário, Millor Fernandes do; Rossi, Jean-Francois; Ledur, Mônica Corrêa; Moura, Ana Silvia Alves Meira Tavares; Coutinho, Luiz Lehmann

doi:10.4238/vol9-1gmr712

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The molecular function of TRIM 39.2 gene is reported as a metal binding ligand (Mcconn et al, 2014). ZNF 692 was found to have a gene ontology (GO) function as a DNA binding transcription repressor activity and specific to RNA polymerase II (Jorge et al, 2010). The ZNF 692 is able to depress or decrease transcription.…”

Section: Functional Annotation Of Genomic Variants Detected In Signat...mentioning

confidence: 99%

Genetic diversity and selection signatures within the major histocompatibility complex of local chicken ecotypes in Kenya

Njau

Bett

Amimo

et al. 2022

EAJSTI

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Diseases remain a major challenge in chicken population leading to reduced performance and economic losses. Whenever possible, chicken population should be reared under production systems with minimum predisposing factors to diseases and other shortcomings during their productive lifetime. Selection for resistance is an attractive option when responding to the diseases challenge. The chicken major histocompatibility complex (MHC) is a highly polymorphic region associated with immune response and disease resistance. The aim of this study was to investigate genetic diversity and as well as identify signatures of selection within the MHC, which help local chicken ecotypes to withstand disease and environmental challenges. A total of eight local chicken ecotype populations from different ecological zones in Kenya and two commercial layers (CL) chicken populations were assessed using single nucleotide polymorphisms (SNPs). Principal component analysis (PCA) showed that the two populations, local chicken ecotypes and commercial chickens were distinct. Expected heterozygosity ranged from 0.21 to 0.28 in local chicken ecotypes and was 0.26 in commercial layers. As expected, inbreeding was much higher in commercial chicken layers at 0.51 - 0.64 than indigenous chickens at 0.04 - 0.27. Selection signature analysis using fixation index (FST) detected two major regions of divergence in commercial and indigenous chickens, within the MHC region mapping to seven genes: KIFC1, ZNF 692, TRIM 7, TRIM 7.2, TRIM 39.2, BLEC 3 and YLEC 1, in local chicken ecotypes which are associated with immune response and disease resistance. This result shows that local chicken ecotypes possess significant genetic diversity within the MHC region, which can be exploited to improve the chicken breeds for disease resistance. However, a comprehensive study using a larger sample size is needed to provide more insight on the viability of the MHC region.

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Section: Functional Annotation Of Genomic Variants Detected In Signat...mentioning

confidence: 99%

Genetic diversity and selection signatures within the major histocompatibility complex of local chicken ecotypes in Kenya

Njau

Bett

Amimo

et al. 2022

EAJSTI

View full text Add to dashboard Cite

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“…Estes autores sugerem que este gene possa desempenhar papel na regeneração de tecidos. Jorge et al (2010), analisando expressão gênica de tecidos musculares oriundos de pools das linhagens TT (corte) e CC (postura), as mesmas empregadas neste estudo, identificaram que o gene TTLL12 foi altamente expresso por meio de análises de macroarrays. A expressão deste gene também foi encontrada em células normais e linhagens de células tumorais de próstata em humano (WASYLYK et al, 2010).…”

Section: Qtl E Genes Candidatosunclassified

Testes de associação em região de QTL ligados do cromossomo 1 da galinha doméstica

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Aos meus queridos e amados pais Paulina e João, Agradeço por terem me dado a oportunidade da vida, por todo o amor, paciência, incentivo, conselhos, exemplos e por estarem sempre ao meu lado, apoiando o meu crescimento moral-espiritual. Aos meus queridos e irmãos Allan e Lísia, pela compreensão, amizade, auxilio e sempre serem meus queridos! DEDICO Ao meu querido namorado Gustavo Mostaço, pela incansável paciência, compreensão e ajuda, pelo seu carinho, amor e dedicação. Obrigada por me fazer feliz! OFEREÇO (FAPESP), pela concessão das bolsas de estudo. Agradeço as amizades que fiz no Laboratório de Biotecnologia Animal da ESALQ:

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Chicken skeletal muscle-associated macroarray for gene discovery

Cited by 2 publications

References 41 publications

Genetic diversity and selection signatures within the major histocompatibility complex of local chicken ecotypes in Kenya

Genetic diversity and selection signatures within the major histocompatibility complex of local chicken ecotypes in Kenya

Testes de associação em região de QTL ligados do cromossomo 1 da galinha doméstica

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