Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice

Souza, Thamiris de; Silva, Simone Vargas da; Fonte-Faria, Thaís; Nascimento-Silva, Vany; Barja‐Fidalgo, Christina; Citelli, Marta

doi:10.1016/j.mce.2020.110772

Cited by 16 publications

(12 citation statements)

References 40 publications

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“…This enzyme can act on the lipid oxidation pathway, increasing mitochondrial beta-oxidation and consequent reduction of liver lipid droplets [40]. A study demonstrated that the administration of 0.15% of chia oil to male C57BL/6 mice for 45 days improved glucose metabolism [41,42]. Overall, our results demonstrate hepatoprotective properties of chia, attenuating the harmful effect caused by saturated fat and fructose and improving glucose uptake.…”

Section: Discussionmentioning

confidence: 55%

“…In addition, the consumption of chia flour and chia oil did not show any effect on IL-10 levels, an anti-inflammatory cytokine, as well as not reducing TLR4, p65 NF-κB, and TNF protein levels. A study administered 0.15% of chia oil to rats fed HFD and there were no differences regarding plasma IL-10 [41]. The addition of 23.26% of chia flour into HFD (51% of fat) did not reduce NF-κB expression and TNF levels in female rat livers [46].…”

Section: Discussionmentioning

confidence: 98%

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Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Moreira

Enes

José

et al. 2022

Foods

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We hypothesized that the consumption of chia (Salvia hispanica L.) flour (CF) and chia oil (CO) improves metabolic disorders in the liver of Wistar rats (Rattus norvegicus domestica) fed a high-fat and high-fructose (HFHF) diet. The animals were fed a HFHF diet (n = 30) or AIN93-M standard diet (n = 10) for eight weeks. After this period, the animals fed HFHF were divided into three groups (n = 10): HFHF diet, HFHF plus 14.7% of CF, and HFHF plus 4% of CO. Histological and biochemical analyses, gene expression, protein levels related to inflammation, and oxidative stress were evaluated in the liver. The HFHF diet caused lipogenesis, liver steatosis, oxidative stress, and inflammation in the animals. The CF and CO intake increased the liver total antioxidant capacity and superoxide dismutase, decreased nitric oxide levels and liver steatosis. Furthermore, the CF and CO led to the upregulation of Cpt1a and Adipor2, respectively, whereas CF downregulated Srebf1. CO intake decreased blood glucose, triglycerides, and the animals’ body weight. Chia did not show effects on mitigating liver pro-inflammatory status, which it may indicate occurs later. The addition of chia into an unbalanced diet is a good and relevant strategy to reduce liver metabolic disorders caused by the high consumption of fructose and saturated fat.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 98%

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Moreira

Enes

José

et al. 2022

Foods

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“…de Souza et al. (2020) reported that chia oil (1.5% w/w), which is rich in alpha‐linolenic fatty acid, would stimulate browning and improved glucose metabolism in male Swiss mice, which produced healthier phenotypes and protected the animals against the development of obesity‐related diseases (de Souza et al., 2020). CSO has been shown to improve insulin and glucose tolerance, as well as hepatic steatosis, visceral obesity, and inflammation.…”

Section: Cso Applicationsmentioning

confidence: 99%

Repurposing chia seed oil: A versatile novel functional food

Tak

Kaur

Kumar³

et al. 2022

Journal of Food Science

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Chia seed oil (CSO) has been recently gaining tremendous interest as a functional food. The oil is rich in with polyunsaturated fatty acids (PUFAs), especially, alpha linolenic acid (ALA), linoleic acid (LA), tocopherols, phenolic acids, vitamins, and antioxidants. Extracting CSO through green technologies has been highly efficient, cost-effective, and sustainable, which has also shown to improve its nutritional potential and proved to be eco-friendly than any other traditional or conventional processes. Due to the presence of valuable bioactive metabolites, CSO is proving to be a revolutionary source for food, baking, dairy, pharmaceutical, livestock feed, and cosmetic industries. CSO has been reported to possess antidiabetic, anticancer, anti-inflammatory, antiobesity, antioxidant, antihyperlipidemic, insect-repellent, and skin-healing properties. However, studies on toxicological safety and commercial potency of CSO are limited and therefore the need of the hour is to focus on large-scale molecular mechanistic and clinical studies, which may throw light on the possible translational opportunities of CSO to be utilized to its complete potential. In this review, we have deliberated on the untapped therapeutical possibilities and novel findings about this functional food, its biochemical composition, extraction methods, nutritional profiling, oil stability, and nutraceutical and pharmaceutical applications for its health benefits and ability to counter various diseases.

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“…Chia seeds are a rich source of dietary fiber, which reduces the hunger sensation, and the omega-3 FA ALA, which is essential for the emulsification and absorption of the liposoluble vitamins A, D, E, and K 6 . Chia oil improved glucose metabolism and promoted the browning process and a healthier phenotype 7 . Chia seeds may help in the prevention, treatment and management of several noncommunicable diseases, improving immunity and perhaps modifying the blood clotting mechanism.…”

Section: Introductionmentioning

confidence: 99%

Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts

Rubavathi¹,

Ganesan²,

Sangeetha³

et al. 2020

J. Drug Delivery Ther.

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Obesity is a condition in which large amount of fat is stored in adipose tissue. Obesity is the greatest risk for many diseases like coronary heart disease, type 2 diabetes millions associated with insulin resistance, arthritis disorder, hypertension and cancers. Currently, the available drugs for obesity have been associated with number of side effects when compared with allopathic drugs. Salvia hispanica was one of the member of Lamiaceae family, collected to study the antiobesity activity. Extraction of Salvia hispanica using different solvents was done and tested for the presence of phytochemical constituents and the antimicrobial activity was monitored to evaluate the zone of inhibition. Further, antioxidant potential activity such as DPPH, FRAP and H2O2 assay was studied. Percentage of inhibition of Salvia hispanica was calculated and was observed as in capturing the free radicals present in the body. The surface and cross-sectional morphology Salvia hispanica extract nanoparticles was examined by using SEM. High ALA content make chia a perfect as it is associated with lower incidence of Cardiovascular diseases. This metabolic syndrome is mediated by inflammatory pathways. Hence, the in vitro activity of anti-inflammatory assay was performed by inhibition of albumin denaturation and anti-obesity activity was performed by lipase inhibition assay. Thus the result indicates that the seed extracts of Salvia hispanica possess antiobesity activity. Keywords: Salvia hispanica, anti-obesity, cholesterol, Antioxidant, lipase inhibition

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Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice

Cited by 16 publications

References 40 publications

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Repurposing chia seed oil: A versatile novel functional food

Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts

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