Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures: A preliminary report

Kimoto, Katsuhiko; Ono, Yumie; Tachibana, Atsumichi; Hirano, Yoshiyuki; Otsuka, Takero; Ohno, Akinori; Yamaya, Katsuhiko; Obata, Takayuki; Onozuka, Minoru

doi:10.1016/j.jpor.2010.09.006

Cited by 51 publications

(66 citation statements)

References 23 publications

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“…Similar results were found in studies of human chewing that used positron emission tomography (PET) (Momose et al, 1997). These and only a few other neuroimaging studies have provided some understanding of human brain activity related to oral function (Bracco et al, 2010;Kimoto et al, 2011) and parafunction (Tamura et al, 2003;Byrd et al, 2009;Jiang et al, 2010).…”

Section: Introduction Msupporting

confidence: 66%

Brain Activity and Human Unilateral Chewing

et al. 2012

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Brain mechanisms underlying mastication have been studied in non-human mammals but less so in humans. We used functional magnetic resonance imaging (fMRI) to evaluate brain activity in humans during gum chewing. Chewing was associated with activations in the cerebellum, motor cortex and caudate, cingulate, and brainstem. We also divided the 25-second chew-blocks into 5 segments of equal 5-second durations and evaluated activations within and between each of the 5 segments. This analysis revealed activation clusters unique to the initial segment, which may indicate brain regions involved with initiating chewing. Several clusters were uniquely activated during the last segment as well, which may represent brain regions involved with anticipatory or motor events associated with the end of the chew-block. In conclusion, this study provided evidence for specific brain areas associated with chewing in humans and demonstrated that brain activation patterns may dynamically change over the course of chewing sequences. KEY WORDS: mastication, feeding behavior, eating, magnetic resonance imaging, neuroimaging, digestive system and oral physiological phenomena.

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Section: Introduction Msupporting

confidence: 66%

Brain Activity and Human Unilateral Chewing

et al. 2012

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“…A critical issue in geriatric oral healthcare is the evaluation of individual variations in adapting to dental prostheses. Animal research has confirmed that occlusal changes can induce neuroplasticity in the motor cortex, and fMRI studies have consistently shown that functional changes in the sensorimotor cortex reflect not just individual differences but also continuous adaptation over time . It should be noted, however, that most of the studies included in the current meta‐analysis were observational and cross‐sectional studies, the results of which cannot be interpreted as effects of the neuroplasticity of oral sensorimotor rehabilitation .…”

Section: Discussionmentioning

confidence: 85%

Meta‐analysis of brain mechanisms of chewing and clenching movements

Lin

2018

J of Oral Rehabilitation

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Functional magnetic resonance imaging (fMRI) is widely used for investigating brain activation patterns associated with chewing and clenching movements. Whether studies consistently identify similar brain loci engaged in these movements remains unknown. We investigated the consistency with which specific brain loci were reported to be activated during teeth-occluding movements, using the activation likelihood estimation (ALE) meta-analysis. Twenty fMRI studies that used fMRI to investigate brain activation during a chewing or clenching task in healthy participants were included. Data from the selected studies were pooled, and ALE methods were used to estimate the likelihood of finding a locus associated with the movements. We found that (i) The bilateral primary motor cortex/supplementary motor area/thalamus, the right primary somatosensory cortex (S1)/secondary somatosensory cortex and the posterior cerebellum (lobule VI) have been identified as reliable loci that show consistently activation when teeth occlude. (ii) The right S1 showed a significant likelihood of activation associated with both chewing and clenching, while the left S1 showed a greater likelihood of activation in chewing than in clenching. (iii) Both younger and older participants showed a significant likelihood of activation in the cerebellum. No significant cluster was identified in the contrast analysis. The fMRI studies reliably identified the sensorimotor cortex, the thalamus and the cerebellum as brain loci associated with chewing and clenching and illustrated a differential activation pattern between chewing and clenching. These findings support the use of fMRI as a potential tool for assessing brain activation patterns related to oral sensorimotor functions in humans.

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“…Another study reported an increase in prefrontal activation, occlusal force, masticatory muscle activity, in people with dentures and young, healthy controls (natural dentate) as compared to people with tooth loss . Similarly, a few other studies, within the limitation of relatively small sample size, have applied the fMRI technique to show different activation patterns of SI with different dental prosthesis . These findings allow several speculations regarding the evaluation of brain activity and functional rehabilitation.…”

Section: Neuroplasticity In Dental Prosthetic Patientsmentioning

confidence: 90%

Bite or brain: Implication of sensorimotor regulation and neuroplasticity in oral rehabilitation procedures

Kumar

Kothari

Grigoriadis

et al. 2018

J of Oral Rehabilitation

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Tooth loss, decreased mass and strength of the masticatory muscles leading to difficulty in chewing have been suggested as important determinants of eating and nutrition in the elderly. To compensate for the loss of teeth, in particular, a majority of the elderly rely on dental prosthesis for chewing. Chewing function is indeed an important aspect of oral health, and therefore, oral rehabilitation procedures should aim to restore or maintain adequate function. However, even if the possibilities to anatomically restore lost teeth and occlusion have never been better; conventional rehabilitation procedures may still fail to optimally restore oral functions. Perhaps this is due to the lack of focus on the importance of the brain in the rehabilitation procedures. Therefore, the aim of this narrative review was to discuss the importance of maintaining or restoring optimum chewing function in the superageing population and to summarise the emerging studies on oral motor task performance and measures of cortical neuroplasticity induced by systematic training paradigms in healthy participants. Further, brain imaging studies in patients undergoing or undergone oral rehabilitation procedures will be discussed. Overall, this information is believed to enhance the understanding and develop better rehabilitative strategies to exploit training-induced cortical neuroplasticity in individuals affected by impaired oral motor coordination and function. Training or relearning of oral motor tasks could be important to optimise masticatory performance in dental prosthesis users and may represent a much-needed paradigm shift in the approach to oral rehabilitation procedures.

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Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures: A preliminary report

Abstract: Despite the limitation of a small sample size, these results suggest that the gum-chewing task in elderly edentulous patients resulted in differential neural activity in the frontal pole within the prefrontal cortex between the 2 prosthodontic therapies-mandibular CD and IOD.

Cited by 51 publications

References 23 publications

Brain Activity and Human Unilateral Chewing

Brain Activity and Human Unilateral Chewing

Meta‐analysis of brain mechanisms of chewing and clenching movements

Bite or brain: Implication of sensorimotor regulation and neuroplasticity in oral rehabilitation procedures

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