Brain Activity and Human Unilateral Chewing

Quintero, A.; Ichesco, Eric; Myers, Chelsea A.; Schutt, R.; Gerstner, Geoffrey E.

doi:10.1177/0022034512466265

Cited by 52 publications

(43 citation statements)

References 28 publications

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“…In previous fMRI reports, in which isotonic muscle contraction was performed with gum-chewing and tooth-tapping tasks, much wider areas of activation were demonstrated in the cortex than in isometric contraction tasks. 13,21,22,24,29 Additionally, no major differences were observed in brain activity within low levels of tooth clenching with controlled force. 30 Quintero et al 24 investigated brain activity during gum-chewing task and found activation in the cerebellum, which is involved in the co-ordination and rhythmicity of oral functions as well as activity in the cortical and subcortical areas.…”

Section: Discussionmentioning

confidence: 88%

“…20 In first-step data analysis for each participant, we calculated BOLD signal changes between clenching and rest blocks and observed activation pattern in the cortical mastication area as described in previous studies (Figures 2 and 4). [21][22][23][24] Byrd et al 14 compared self-reporting patients with bruxism and the control group using fMRI. They found hypoactivation in the motor cortex (supplementary motor area, sensorymotor area and rolandic operculum) and the subcortical (caudate) areas in patients with bruxism in parafunctional movements.…”

Section: Discussionmentioning

confidence: 99%

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To see bruxism: a functional MRI study

Yılmaz

2015

Dentomaxillofacial Radiology

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Objective: Since the pathophysiology of bruxism is not clearly understood, there exists no possible treatment. The aim of this study is to investigate the cerebral activation differences between healthy subjects and patients with bruxism on behalf of possible aetiological factors. Methods: 12 healthy subjects and 12 patients with bruxism, a total of 24 right-handed female subjects (aged 20-27 years) were examined using functional MRI during tooth-clenching and resting tasks. Imaging was performed with 3.0-T MRI scanner with a 32-channel head coil. Differences in regional brain activity between patients with bruxism and healthy subjects (control group) were observed with BrainVoyager QX 2.8 (Brain Innovation, Maastricht, Netherlands) statistical data analysis program. Activation maps were created using the general linear model: single study and multistudy multisubject for statistical group analysis. This protocol was approved by the ethics committee of medical faculty of Kirikkale University, Turkey (02/04), based on the guidelines set forth in the Declaration of Helsinki. Results: The group analysis revealed a statistically significant increase in blood oxygenation level-dependent signal of three clusters in the control group (p , 0.005), which may indicate brain regions related with somatognosis, repetitive passive motion, proprioception and tactile perception. These areas coincide with Brodmann areas 7, 31, 39 and 40. It is conceivable that there are differences between healthy subjects and patients with bruxism. Conclusions: Our findings indicate that there was a decrease of cortical activation pattern in patients with bruxism in clenching tasks. This indicates decreased blood flow and activation in regional neuronal activity. Bruxism, as an oral motor disorder concerns dentistry, neurology and psychiatry. These results might improve the understanding and physiological handling of sleep bruxism.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

To see bruxism: a functional MRI study

Yılmaz

2015

Dentomaxillofacial Radiology

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“…Previous studies have identified brain activation of the cerebellum and the motor cortex when participants were chewing (Onozuka et al, 2002; Quintero et al, 2013). In the current study, we further investigated the brain signatures associated with masticatory performance, a widely used index for evaluating the masticatory function of elderly people.…”

Section: Discussionmentioning

confidence: 99%

“…However, as a highly coordinated rhythmic and automatic movement, mastication is also regulated by the central nervous system (CNS; Avivi-Arber et al, 2011). Neuroimaging evidence has suggested that mastication is associated with the brain activity in the cortical sensory and motor regions, the subcortical regions, and the cerebellum (Onozuka et al, 2002; Quintero et al, 2013). Furthermore, in elderly healthy subjects, good masticatory ability, as indexed by higher masticatory performance, was associated with greater gray matter volume at the premotor cortex (PMC) and an increased resting-state functional connectivity (FC) with the cerebellum (Lin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Age-Related Difference in Functional Brain Connectivity of Mastication

Lin

et al. 2017

Front. Aging Neurosci.

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The age-related decline in motor function is associated with changes in intrinsic brain signatures. Here, we investigated the functional connectivity (FC) associated with masticatory performance, a clinical index evaluating general masticatory function. Twenty-six older adults (OA) and 26 younger (YA) healthy adults were recruited and assessed using the masticatory performance index (MPI) and resting-state functional magnetic resonance imaging (rs-fMRI). We analyzed the rs-fMRI FC network related to mastication, which was constructed based on 12 bilateral mastication-related brain regions according to the literature. For the OA and the YA group, we identified the mastication-related hubs, i.e., the nodes for which the degree centrality (DC) was positively correlated with the MPI. For each pair of nodes, we identified the inter-nodal link for which the FC was positively correlated with the MPI. The network analysis revealed that, in the YA group, the FC between the sensorimotor cortex, the thalamus (THA) and the cerebellum was positively correlated with the MPI. Consistently, the cerebellum nodes were defined as the mastication-related hubs. In contrast, in the OA group, we found a sparser connection within the sensorimotor regions and cerebellum and a denser connection across distributed regions, including the FC between the superior parietal lobe (SPL), the anterior insula (aINS) and the dorsal anterior cingulate cortex (dACC). Compared to the YA group, the network of the OA group also comprised more mastication-related hubs, which were spatially distributed outside the sensorimotor regions, including the right SPL, the right aINS, and the bilateral dACC. In general, the findings supported the hypothesis that in OA, higher masticatory performance is associated with a widespread pattern of mastication-related hubs. Such a widespread engagement of multiple brain regions associated with the MPI may reflect an increased demand in sensorimotor integration, attentional control and monitoring for OA to maintain good mastication.

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“…The investigators interpreted this to mean that somatosensory feedback via the vSI towards the motor cortex might play a particularly important role in the development of classical singing skills. Chewing, a more vital orofacial function, was also reported to activate the vSI bilaterally [7,8]. This suggests that chewing also requires information processing in the vSI to control or monitor a series of movements despite its semi-automatic nature.…”

Section: Introductionmentioning

confidence: 97%

The Ventral Primary Somatosensory Cortex of the Primate Brain: Innate Neural Interface for Dexterous Orofacial Motor Control

Tsuruo

Kudo

2015

Interface Oral Health Science 2014

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Studies using nonhuman primates have made marked contributions to our understanding of the anatomy and function of the primary somatosensory cortex (SI). Its ventral or inferolateral part (vSI) represents orofacial structures, such as the lips, periodontium, tongue, palate, chewing musculature, etc. This brain region is neurally interconnected with the ventral part of the primary motor cortex that executes voluntary orofacial movements. Also within the vSI, regions representing different orofacial structures are interconnected with each other. Therefore, in selfgenerated actions, the vSI plays a crucial role in coordinating motor control of a set of structures that are functionally related: the vSI serves as an interface not only between orofacial structures and the external environment but also between the orofacial structures themselves. In this article, we will chiefly review the neuroanatomical and neurophysiological studies on the monkey vSI from the viewpoint of motor control or stereognostic ability. Future physiological studies that analyze the spatiotemporal spiking pattern of vSI neurons during various behaviors in monkeys should reveal the principles of information coding and might significantly benefit future applications of brain-machine-brain interface (BMBI) technology.

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Brain Activity and Human Unilateral Chewing

Cited by 52 publications

References 28 publications

To see bruxism: a functional MRI study

To see bruxism: a functional MRI study

Age-Related Difference in Functional Brain Connectivity of Mastication

The Ventral Primary Somatosensory Cortex of the Primate Brain: Innate Neural Interface for Dexterous Orofacial Motor Control

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