Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis

Kilcoyne, Aoife; Lavelle, Lisa P.; McCarthy, Colin J.; McEvoy, Sinéad H.; Fleming, Hannah; Gallagher, Annika; Loeve, Martine; Tiddens, Harm A.W.M.; McKone, Edward F.; Gallagher, Charles C.; Dodd, Jonathan D.

doi:10.21037/atm.2016.03.08

Cited by 15 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CFQ-R was approved by the U.S. Food and Drug Administration for use in clinical trials [ 8 , 9 ]. The main publications that used this questionnaire aimed to establish correlations between CF HRQoL and clinical, bacteriological, or tomodensitometric features [ 10 , 11 , 12 ]. A recent systematic review of the literature showed that FEV1% predicted and pulmonary exacerbations were the strongest predictors of HRQoL [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

et al. 2022

View full text Add to dashboard Cite

Background: Cystic Fibrosis (CF) adult patients experience daily physical symptoms and disabilities that may impact their quality of life and mental health. Methods: This prospective study aimed to evaluate the relative contribution of the familial, occupational, and social environment, besides that of the main physical and mental health factors, to the quality of life of CF adult patients using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) in a multivariate model. Results: Fifty patients were analyzed (70% of men; median age of 25 years; median body mass index of 21 kg/m²; median FEV1 of 57%). Anxiety and depression scores were negatively associated with 9 of the 12 CFQ-R domains. When controlling for anxiety and depression, FEV1% and BMI were significant positive predictors of several domains of the CFQ-R. All the familial, occupational, and social components analyzed but one (professional training) were predictors of at least one domain of the CFQ-R. Conclusion: Anxiety and depression explained a greater proportion of the variance than physical variables (age, sex, BMI, FEV1%, and exacerbation in the last year) in CF HRQoL. Many familial, occupational, and social components were also specifically and independently predictors of some HRQoL domains. Their screening might help identifying CF patients eligible for specific interventions, focusing on the impaired QoL dimensions.

show abstract