Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

Ancel, Julien; Launois, Claire; Perotin, Jeanne-Marie; Ravoninjatovo, Bruno; Mulette, Pauline; Hagenburg, Jean; Malet, Julie; Griffon, Muriel; Carré, Sophie; Lebargy, F.; Deslée, G.; Dury, Sandra

doi:10.3390/healthcare10071351

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…29 Additional factors such as anxiety, depression, familiar, social, financial, and educational may also play an important role in these patients. 30,31 Nevertheless, despite finding no statistically significant effects in quality of life for most domains, in this study, a clinically relevant effect was found in the role functioning domain.…”

Section: Discussioncontrasting

confidence: 85%

Effects of a remotely supervised resistance training program on muscle strength and body composition in adults with cystic fibrosis: Randomized controlled trial

Sosa‐Pedreschi,

Donadio,

Iturriaga‐Ramírez

et al. 2024

Scandinavian Med Sci Sports

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IntroductionAmong the limited studies on physical exercise interventions in adults with cystic fibrosis (CF), few have specifically addressed the improvement of peripheral muscle strength and body fat‐free mass. The aim of this study was to examine the impacts of a remotely supervised, individualized 8‐week resistance training program of moderate to high intensity on strength and body composition in these subjects.MethodsThis was a randomized controlled trial performed in adults with CF. The exercise group (EX) performed three 1‐h resistance training sessions per week over 8 weeks. The control group (CON) followed the physical activity recommendations of their physician. The main outcomes were muscle strength and body composition, with secondary measures including pulmonary function and quality of life. Two‐way repeated measures analysis was used.ResultsIn 23 participants (age 32.13 ± 7.72 years), the intervention showed a significant beneficial effect on leg press strength, with a large effect size, both in absolute (p = 0.011; = 0.281) and relative (p = 0.007; = 0.310) terms. Large intervention effects were observed on total fat mass (p < 0.001; = 0.415), body adiposity index (p < 0.001; = 0.436), and fat mass index (p < 0.001; = 0.445), all showing reduction in the EX group. In addition, significant large size effects were detected on total fat‐free mass (p = 0.046; = 0.177), trunk fat‐free mass (p = 0.039; = 0.188), and fat‐free mass index (p = 0.048; = 0.174), all favoring exercise. No significant effects were observed on pulmonary function and quality of life.ConclusionsAn 8‐week remotely supervised resistance training program, with moderate to high intensity, effectively improved lower limb muscle strength and body composition.

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Section: Discussioncontrasting

confidence: 85%

Effects of a remotely supervised resistance training program on muscle strength and body composition in adults with cystic fibrosis: Randomized controlled trial

Sosa‐Pedreschi,

Donadio,

Iturriaga‐Ramírez

et al. 2024

Scandinavian Med Sci Sports

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“…A higher proportion of body fat and an increased rate of leptin synthesis per unit mass of adipose tissue may explain the higher level of serum leptin in women than in men ( 24 ). Moreover, elevated leptin levels may be associated with depression and anxiety experienced by CF patients, requiring further investigation and multivariate analysis ( 25 – 27 ).…”

Section: Discussionmentioning

confidence: 99%

Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study

et al. 2022

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Along with the significant elongation in the average life expectancy of patients with cystic fibrosis (CF), there are still significant discrepancies in the height, weight, and body mass index (BMI) of patients compared to controls without CF. The correlation between hormones that regulate appetite and body fat mass may be an additional factor in weight loss or poor weight gain in CF patients. Our objective was to estimate serum concentrations of leptin and neuropeptide Y in patients with CF as well as to assess correlations between studied hormones and the clinical parameters of CF. Leptin and neuropeptide Y serum concentrations after an overnight fast were measured using an enzyme-linked immunosorbent assay. All study participants had anthropometric tests and spirometry. In addition, fasting serum lipid profile was also analyzed. Fasting leptin levels in CF were significantly higher in patients with CF patients (13.9 ± 6.9 vs. 6.5 ± 2.6 ng/mL, p < 0.001) compared to controls. There were no differences in leptin concentration between female and male CF participants (15.7 ± 7.8 vs. 12.2 ± 5.6 ng/mL, p = 0.13). Leptin was correlated with age (R = 0.64, p < 0.001), BMI (R = 0.65, p < 0.001), spirometry results (R = −0.49, p < 0.01), and body fat (R = 0.5, p < 0.05). There were no differences in neuropeptide Y concentration between participants with CF and controls as well as neuropeptide Y was not correlated with any studied parameters. The results of our study suggest that weight loss may be associated with a decreased level of leptin, while reduced pulmonary function in CF may be related to an elevated level of leptin.

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“…However, BMI was negatively correlated with the emotional functioning domain (r = −0.31, p ≤ 0.05) [ 47 ]. In the French study, adults with CF had the highest median (80) in the emotional domain [ 48 ]. Considering these results, we concluded that the COVID-19 pandemic did not influence the perceived quality of life in the emotional functioning domain of our study group.…”

Section: Discussionmentioning

confidence: 99%

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

Humaj-Grysztar

Rachel

Śmiech-Michalec

et al. 2022

IJERPH

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Research shows that people with cystic fibrosis are more prone to suffer from psychological problems than healthy people; thus, the outbreak of the COVID-19 pandemic in Poland could have had an impact on their mental health. To assess this impact, we examined the mental health of patients before and during the pandemic. Survey participants were asked to fill in questionnaires that consisted of Beck Depression Inventory (BDI), 12-Item General Health Questionnaire (GHQ-12) and Cystic Fibrosis Questionnaire-Revised (CFQ-R; for the purpose of the study, an emotional functioning domain was used) during their hospital visits. A total of 81 patients took part in the study: 39 before the COVID-19 pandemic (BP) and 42 during the COVID-19 pandemic (DP). Patients’ medians were lower for the BDI, GHQ-12 and higher for the emotional domain of CFQ-R during the pandemic (3, 6, 75 vs. 4, 10, 73.33). Fewer patients felt that their mental health had deteriorated during the pandemic (Δχ2 = 7.723; p = 0.005), and GHQ-12 scores were lower in the DP group (Z = −3.044; p = 0.002). No significant differences were found between groups in terms of experiencing depressive symptoms (Δχ2 = 1.036; p = 0.309). It was found that patients with cystic fibrosis from our study group not only maintained but also improved their mental health state during the COVID-19 pandemic.

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Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

Cited by 6 publications

References 51 publications

Effects of a remotely supervised resistance training program on muscle strength and body composition in adults with cystic fibrosis: Randomized controlled trial

Effects of a remotely supervised resistance training program on muscle strength and body composition in adults with cystic fibrosis: Randomized controlled trial

Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

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