Chemotype diversity of Psidium guajava L.

Souza, Tércio da Silva de; Ferreira, Márcia Flores da Silva; Menini, Luciano; Souza, Jaqueline Rodrigues Cindra de Lima; Bernardes, Carolina de Oliveira; Ferreira, Adésio

doi:10.1016/j.phytochem.2018.06.006

Cited by 25 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These quantitative changes were attributed to environmental factors. 26 Leaves of P. guineense EO from the Brazilian Midwest showed high amounts of spathulenol (80.7%). 11 However, P. guineense from Brazilian Amazon displayed β-bisabolol (17.4%), limonene (6.8%), and epi -α-bisabolol (6.7%) as main constituents.…”

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

“…Literature data have already demonstrated the feasibility of applying P. guajava OE in the pharmacological sector due to its variability of organic compounds, as well as its efficiency in preliminary tests of anti-inflammatory activity, indicating possible viability in combating gastric ulcers. 26,34 In addition, significant cytotoxic activity was reported by the P. guineense essential oil against ovarian cancer cells (OVCAR-3) with GI50 of 0.9 µg/m. 35 Moreover, literature data indicate that Ecaryophyllene, a compound detected in all samples of Myrtaceae essential oils in this study, has a potent anticancer activity, affecting the growth and proliferation of different types of cancer cells.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Jerônimo

Costa

Pinto

et al. 2021

Natural Product Communications

View full text Add to dashboard Cite

This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-β-bisabolol (16.1%) as the main compound. However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and α-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC505.8 µg/mL), gastric (AGP01, IC503.2 µg/mL), and colon (HCT116, IC506.7 µg/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC5012.4 µg/mL and 11.6 µg/mL, respectively).

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Cytotoxic Activitymentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Jerônimo

Costa

Pinto

et al. 2021

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…Gas chromatography coupled to mass spectrometry (GC-MS) is the most frequently used hyphenated separation technique for the characterization and identification of volatile organic compounds found in such oils [19][20][21][22]. However, the complex nature of the samples and the existence of coelutions are a challenge for qualitative and quantitative analysis [23,24].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Varronia curassavica Jacq. Terpenoids by Flow Modulated Two-Dimensional Gas Chromatography Coupled to Mass Spectrometry

2020

View full text Add to dashboard Cite

In this study, a metabolomic approach was used to investigate the effect of seasonality on the chemical composition and yield of anti-inflammatory active principle, α-humulene, in the essential oil of three genotypes of Varronia curassavica Jacq. (Syn. Cordia verbenaceae). The essential oils were extracted by hydrodistillation and analyzed by comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC-MS). The GC×GC approach a three-fold improvement in qualitative analysis (48 compounds were identified by GC-MS versus 135 by GC×GC-MS). The improved resolving power of GC×GC resolved important coelutions and enabled the detection of unusual substances in V. curassavica essential oil. The chromatographic data was analyzed by using peak table-based chemometrics, namely, principal component analysis (PCA) and hierarchical cluster analysis (HCA). The metabolic study showed that seasonality has a significant effect on the chemical composition. The α-humulene content was affected by genotype and season. Spring and summer were the best harvest seasons for the yield of the active ingredient, found in higher concentrations in the VC2 genotype. The proposed metabolomic workflow was successfully applied to terpene analysis found in V. curassavica essential oil, and such results have broadened our understanding of the influence of seasonal factors on the specialized metabolism of the species.

show abstract

“…A small but growing body of research has examined IPV prevalence and correlates among pregnant women who choose to terminate their pregnancy by seeking elective abortion services 36,162,[174][175][176][177][178][179][180][181][182][183][184][185][384][385][386][387][388] . However, most of the studies that examined IPV in women seeking pregnancy termination were limited in sample size and descriptive in nature.…”

Section: Intimate Partner Violence and Pregnancy Terminationmentioning

confidence: 99%

Intimate partner violence, employment and social support among women seeking elective abortion services In Iowa

Baydoun¹

View full text Add to dashboard Cite

Intimate partner violence ………………………………………………..63 Employment characteristics ……………………………………………..64 Woman's and partner's employment status ……………………..64 Woman's and partner's type of occupation ……………………..65 Discrepancies in employment status……………………………..66 Health correlates …………………………………………...........67 Woman's substance use…………………………………67 Alcohol intake …………………………………..68 Binge drinking and recreational drug use ……….68 Partner's substance use ………………………………….69 Alcohol intake …………………………………...69 Binge drinking and recreational drug use ……….70 Categorization of alcohol intake ………………………...70 Woman's depressive symptoms ………………………....73 Woman's social support …………………………………………………74 Covariates………………………………………………………………..74 Woman's and partner's age ……………………………………..74 Woman's and partner race and ethnicity ………………………..74 Woman's and partner's education ………………………………75 Woman's and partner's health insurance status ………………...75 Marital status and living arrangements …………………………76 Child status ……………………………………………………...76 Field procedures …………………………………………………………………76 Sample size calculations ………………………………………………………...80 Subject selection ………………………………………………………………...81 Plan of analysis ………………………………………………………………….82 Characterization of survey participants …………………………………84 Aim I …………………………………………………………………….85 Aim II ……………………………………………………… ……………86 viii CHAPTER IV CHARACTERIZATION OF SURVEY PARTICIPANTS…….. 88

show abstract

Chemotype diversity of Psidium guajava L.

Cited by 25 publications

References 23 publications

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Metabolic Profiling of Varronia curassavica Jacq. Terpenoids by Flow Modulated Two-Dimensional Gas Chromatography Coupled to Mass Spectrometry

Intimate partner violence, employment and social support among women seeking elective abortion services In Iowa

Contact Info

Product

Resources

About