Chemotherapy with hybrid liposomes for lymphoma without drugs in vivo

Specific Interaction between Ca2+ and Anionic Lipids in Cancer Cells along with Apoptosis

“…11,15) After the pre-culture of tumor cells (2.0ϫ10 4 ]ϭ10 mM) for 72 h, and used for these experiments.…”

“…5) With respect to the role of Ca 2ϩ in inhibition of cellular proliferation, it has been reported that Ca 2ϩ imported into the cytoplasm of mammalian cells could lead to a programmed cell death "apoptosis" through several signalling pathways. 6,7) However, the mechanistic details of tumor-specific growth inhibition effects of Ca On the other hand, we have investigated the membrane targeted chemotherapy with hybrid liposomes 8,9) composed of phospholipids and nonionic surfactants for tumor cells in vitro, [10][11][12][13][14][15] in vivo, 15,16) and in clinical applications. 16,17) Significantly, the denaturation of cell membranes by hybrid liposomes could lead to apoptosis in tumor cells without any drugs.…”

Membrane-Targeted Nanotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis

“…[24][25][26][27] The particle size of HL-n was measured by dynamic light scattering measurements. 22 HL-n had hydrodynamic mean diameters of between 60 and 90 nm with a single and narrow range of size distribution ( Figure S1, Supporting Information).…”

“…20 On the other hand, we have reported that hybrid liposomes (HL-n) composed of DMPC and polyoxyethylene(n) dodecyl ethers (C 12 (EO) n ) without any drugs inhibited the proliferation of various cancer cells along with apoptosis in vitro 21-23 and in vivo. 24,25 Furthermore, successful clinical chemotherapy with drug-free HL-n to patients with lymphoma has been reported. 26,27 Significantly, we …”

Apoptotic and Anti-invasive Effects of Hybrid Liposomes without Drugs against Human Breast Cancer Cells In Vitro

“…Studies of HL made of DMPC and polyoxyethylene (n) dodecyl ethers (C 12 (EO) n ) on the in vitro [7][8][9] and in vivo [9][10][11][12] development of lymphoma cells, and clinical applications [12] without drugs have already been reported. In chemotherapy for HER2-negative breast cancer, invasive suppression and the apoptotic induction of breast cancer cell are important treatment strategies.…”