Chemotherapy pro-drug activation by biocatalytic virus-like nanoparticles containing cytochrome P450

Sánchez-Sánchez, Lorena; Cadena-Nava, Rubén D.; Palomares, Laura A.; Ruíz-García, Jaime; Koay, M.S.T.; Cornelissen, Jeroen J.M.T.; Vázquez-Duhalt, Rafael

doi:10.1016/j.enzmictec.2014.04.003

Cited by 79 publications

(61 citation statements)

References 58 publications

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“…VLPs have been utilized to encapsulate diverse materials, such as metallic nanoparticles, drugs,, DNA,, RNAs,, proteins and enzymes,,, to obtain new materials, nanoreactors and delivery systems.…”

Section: Resultsmentioning

confidence: 99%

Virus‐Based Nanomotors for Cargo Delivery

et al. 2018

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Self‐propelled nanomotors based on virus structure were designed, fabricated and characterized. Capsids from plant virus were covered on one hemisphere with platinum layer to promote motion in the presence of hydrogen peroxide. The Janus viral nanomotors (JVNs) with 25–30 nm diameter from brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) showed motion speeds of up to 9 μm/sec, depending of the peroxide fuel concentration in the medium. The JVNs can carry and deliver the chemo‐therapeutic drug Tamoxifen, and they are able to internalize into breast tumor cells without any functionalization. The therapeutic payload is released by a pH‐driven delivery action of the nanomotor. Here, the first proof of concept of a self‐propelled virus‐like nanoparticle is demonstrated. The attractive capabilities of nanomotors based on virus‐like nanoparticles (VLPs) pave the way to diverse biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Virus‐Based Nanomotors for Cargo Delivery

et al. 2018

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“…This conversion is often inefficient and occurs in healthy tissues away from the tumor, resulting in off target cytotoxicity (Moen et al, 2012). To address this issue CCMV ePVNs were used to encapsulate via electrostatic interactions a soluble version of a bacterial CYP (Sanchez-Sanchez et al, 2014). CCMV encapsulated CYP readily converted Resveratrol and tamoxifen prodrug formulations to their active forms and at levels comparable or greater than observed in human liver microsomal preparations.…”

Section: Nanoreactors For Enzymatic and Therapeutic Conversionmentioning

confidence: 99%

Plant virus directed fabrication of nanoscale materials and devices

et al. 2015

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Bottom-up self-assembly methods in which individual molecular components self-organize to form functional nanoscale patterns are of long-standing interest in the field of materials sciences. Such self-assembly processes are the hallmark of biology where complex macromolecules with defined functions assemble from smaller molecular components. In particular, plant virus-derived nanoparticles (PVNs) have drawn considerable attention for their unique self-assembly architectures and functionalities that can be harnessed to produce new materials for industrial and biomedical applications. In particular, PVNs provide simple systems to model and assemble nanoscale particles of uniform size and shape that can be modified through molecularly defined chemical and genetic alterations. Furthermore, PVNs bring the added potential to "farm" such bio-nanomaterials on an industrial scale, providing a renewable and environmentally sustainable means for the production of nano-materials. This review outlines the fabrication and application of several PVNs for a range of uses that include energy storage, catalysis, and threat detection.

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“…This is accomplished through denaturation of the cage structure and reassembling it in the presence of cargos [28,53]. In many cases the specificity and loading efficiency can be increased through the use of electrostatics [21,25,38,54–56]. Unfortunately, complete modification of each core monomer with internal cargos often interferes with VLP assembly, and a more successful approach for cargo loading was achieved by in vitro mixing of genetically modified and unmodified core monomers [16].…”

Section: Cargo Encapsulationmentioning

confidence: 99%

Protein nanoparticles as multifunctional biocatalysts and health assessment sensors

Raeeszadeh‐Sarmazdeh

Hartzell

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et al. 2016

Current Opinion in Chemical Engineering

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The use of protein nanoparticles for biosensing, biocatalysis and drug delivery has exploded in the last few years. The ability of protein nanoparticles to self-assemble into predictable, monodisperse structures is of tremendous value. The unique properties of protein nanoparticles such as high stability, and biocompatibility, along with the potential to modify them led to development of novel bioengineering tools. Together, the ability to control the interior loading and external functionalities of protein nanoparticles makes them intriguing nanodevices. This review will focus on a number of recent examples of protein nanoparticles that have been engineered towards imparting the particles with biocatalytic or biosensing functionality.

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Chemotherapy pro-drug activation by biocatalytic virus-like nanoparticles containing cytochrome P450

Cited by 79 publications

References 58 publications

Virus‐Based Nanomotors for Cargo Delivery

Virus‐Based Nanomotors for Cargo Delivery

Plant virus directed fabrication of nanoscale materials and devices

Protein nanoparticles as multifunctional biocatalysts and health assessment sensors

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