Chemotherapy-induced modification of microRNA expression in esophageal cancer

Hummel, Richard

doi:10.3892/or.2011.1381

Cited by 68 publications

(70 citation statements)

References 27 publications

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“…Furthermore, miR-425 was detected at high levels in gastric cancer (55). Hummel et al (56) revealed that miR-425 was also upregulated in esophageal carcinoma cells following short-or long-term treatment with cisplatin. miR-25, which is overexpressed in ovarian cancer, gastric cancer and esophageal squamous cell carcinoma, promotes tumorigenesis and metastasis by targeting Bim, reversion-inducing cysteine-rich protein with Kazal motifs and cadherin 1, respectively (57)(58)(59).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

Li¹,

Zhang²,

Liu³

et al. 2015

Oncology Letters

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Abstract. MicroRNAs (miRNAs) are a family of small non-protein coding RNAs, which regulate the expression of a wide variety of genes at the post-transcriptional level to control numerous biological and pathological processes. Various circulating miRNAs have been identified as potential diagnostic and prognostic biomarkers in multiple types of cancer and disease. The aim of the present study was to identify potential miRNA biomarkers for the early diagnosis and relapse prediction of osteosarcoma (OS). miRNA profiling was performed on serum from patients with osteosarcoma and healthy controls. All putative miRNAs were verified by reverse transcription-quantitative polymerase chain reaction analysis of 20 pre-therapeutic OS patients and 20 healthy individuals. The expression of miR-106a-5p, miR16-5p, miR-20a-5p, miR-425-5p, miR451a, miR-25-3p and miR139-5p was demonstrated to be downregulated in the serum of OS patients when compared with that of the healthy controls. Receiver-operating characteristic curve analyses indicated that these 7 miRNAs may be used as diagnostic biomarkers with the ability to discriminate between the healthy cohort and patients with OS. These results provide novel insights into the use of miRNAs in early blood screening for OS.

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Section: Discussionmentioning

confidence: 99%

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

Li¹,

Zhang²,

Liu³

et al. 2015

Oncology Letters

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“…Interestingly, new findings suggest that miRNAs also affect drug resistance in colorectal cancer (37). For instance, Mir455-3p, predicted to bind in SMUG1 3 0 -UTR where rs2233921 resides, may target molecular pathways involved in cell survival after 5-FU or cisplatin chemotherapy (38). miRNA pharmacogenomics is a novel and promising field that investigates the role of miRNAs and polymorphisms affecting miRNAs and their target functions for the prediction of drug response or the improvement of drug efficiency (39).…”

Section: Survival Analysismentioning

confidence: 99%

Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding

Pardini

Rosa

Barone

et al. 2013

Clinical Cancer Research

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Purpose: Colorectal cancer is routinely treated with a 5-fluorouracil (5-FU)-based chemotherapy. 5-FU incorporates into DNA, and the base excision repair (BER) pathway specifically recognizes such damage. We investigated the association of single-nucleotide polymorphisms (SNP) in the 3 0 -untranslated regions (UTR) of BER genes, and potentially affecting the microRNA (miRNA) binding, on the risk of colorectal cancer, its progression, and prognosis. SNPs in miRNA-binding sites may modulate the posttranscriptional regulation of gene expression operated by miRNAs and explain interindividual variability in BER capacity and response to 5-FU. Experimental Design: We tested 12 SNPs in the 3 0 -UTRs of five BER genes for colorectal cancer susceptibility in a case-control study (1,098 cases and 1,459 healthy controls). Subsequently, we analyzed the role of these SNPs on clinical outcomes of patients (866 in the Training set and 232 in the Replication set).Results: SNPs in the SMUG1 and NEIL2 genes were associated with overall survival. In particular, SMUG1 rs2233921 TT carriers showed increased survival compared with those with GT/GG genotypes [HR, 0.54; 95% confidence interval (CI), 0.36-0.81; P ¼ 0.003] in the Training set and after pooling results from the Replication set. The association was more significant following stratification for 5-FU-based chemotherapy (P ¼ 5.6 Â 10 À5 ). A reduced expression of the reporter gene for the T allele of rs2233921 was observed when compared with the common G allele by in vitro assay. None of the genotyped BER polymorphisms were associated with colorectal cancer risk. Conclusions:We provide the first evidence that variations in miRNA-binding sites in BER genes 3 0 -UTR may modulate colorectal cancer prognosis and therapy response.

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“…2D). The direct targets of miR-766 have not been identified, but its predicted targets are involved in pathways associated with cell survival after chemotherapy and aging (27,64). The deregulation of these miRNAs, along with others, indicate that the downregulation of cell cycle-related pathways is an important feature of infA infection.…”

Section: Figmentioning

confidence: 99%

Temporal- and Strain-Specific Host MicroRNA Molecular Signatures Associated with Swine-Origin H1N1 and Avian-Origin H7N7 Influenza A Virus Infection

Loveday

Svinti

Diederich

et al. 2012

J Virol

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MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to virus-associated diseases involving members of the Hepacivirus , Herpesvirus , and Retrovirus families. In contrast, limited biological and molecular information has been reported on the potential role of cellular miRNAs in the life cycle of influenza A viruses (infA). In this study, we hypothesize that elucidating the miRNA expression signatures induced by low-pathogenicity swine-origin infA (S-OIV) pandemic H1N1 (2009) and highly pathogenic avian-origin infA (A-OIV) H7N7 (2003) infections could reveal temporal and strain-specific miRNA fingerprints during the viral life cycle, shedding important insights into the potential role of cellular miRNAs in host-infA interactions. Using a microfluidic microarray platform, we profiled cellular miRNA expression in human A549 cells infected with S- and A-OIVs at multiple time points during the viral life cycle, including global gene expression profiling during S-OIV infection. Using target prediction and pathway enrichment analyses, we identified the key cellular pathways associated with the differentially expressed miRNAs and predicted mRNA targets during infA infection, including the immune system, cell proliferation, apoptosis, cell cycle, and DNA replication and repair. By identifying the specific and dynamic molecular phenotypic changes (microRNAome) triggered by S- and A-OIV infection in human cells, we provide experimental evidence demonstrating a series of temporal and strain-specific host molecular responses involving different combinatorial contributions of multiple cellular miRNAs. Our results also identify novel potential exosomal miRNA biomarkers associated with pandemic S-OIV and deadly A-OIV-host infection.

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Chemotherapy-induced modification of microRNA expression in esophageal cancer

Cited by 68 publications

References 27 publications

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma

Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding

Temporal- and Strain-Specific Host MicroRNA Molecular Signatures Associated with Swine-Origin H1N1 and Avian-Origin H7N7 Influenza A Virus Infection

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