Chemotherapy induced histopathological changes in retinoblastoma, assessment of high risk predictive factors &amp; its correlation with comorbid conditions

Yaqoob, Nausheen; Mansoor, Salima; Zia, Nida; Aftab, Khalid; Kaleem, Bushra; Jamal, Saba

doi:10.12669/pjms.38.icon-2022.5786

Cited by 2 publications

(1 citation statement)

References 14 publications

(17 reference statements)

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“…In high-income countries, the incidence of histopathological high-risk features after enucleation had declined over the years due to early diagnosis and referral; however, cases are still reported from LMICs like Pakistan [ 12 , 13 ]. Post enucleation histopathological features play an important role in assessing the disease severity, results from high-income countries cannot be generalized as presentation of disease differs in LMICs [ 14 ]. The purpose of our study was to analyse the survival outcomes of adjuvant therapy based on histopathological risk stratification in patients who underwent upfront enucleation for unilateral RB with advanced disease.…”

Section: Introductionmentioning

confidence: 99%

Survival outcomes of unilateral retinoblastoma based on pathological risk stratification-experience at a tertiary care centre in Pakistan

Shaheen¹,

Inayat²,

Bashir³

et al. 2022

ecancer

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Retinoblastoma (RB) is the most common childhood intraocular malignancy. In highincome countries over the past decade, upfront enucleation for unilateral RB is least favoured due to other alternatives that can help in globe preservation, but in low-middle income countries it is still the preferred option due to lack of resources and expertise. The treatment of RB after enucleation is tailored based on the histopathological risk features, as adjuvant chemotherapy with high-risk features reduces the risk of metastasis. The aim of our study was to analyse the survival outcomes of adjuvant therapy based on histopathological risk stratification in patients who underwent upfront enucleation for unilateral RB with advanced disease. A retrospective study was carried out at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan. A total 113 patients (aged 3 months till 16 years) diagnosed with unilateral RB who had upfront enucleation from July 2009 till January 2019 were included in this study. The mean age of diagnosis was 37.4 months (±24.5) and male-to-female ratio of 1.3:1. The most common clinical presentation was leukocoria (74.3%). Patients who underwent enucleation had advanced disease; group D present in 62.8% followed by group E (32.7%). Histopathology revealed high-risk features in 29 patients (25.7%) and intermediate risk in 54 patients (47.8%). Disease progression and relapse was seen in patients with high-risk histopathological features. The 4-year over-all survival and EFS observed for this cohort was 74% and 71%. Awareness about the early symptoms among the general population and health care personnel at a nationwide level is needed to facilitate early detection and lessen disease related morbidity and mortality.

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Section: Introductionmentioning

confidence: 99%

Survival outcomes of unilateral retinoblastoma based on pathological risk stratification-experience at a tertiary care centre in Pakistan

Shaheen¹,

Inayat²,

Bashir³

et al. 2022

ecancer

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Evaluation of high risk histopathology features in primary and secondary enucleated retinoblastoma-study of 136 cases in tertiary eye hospital

Bhanvadia,

Patel,

Patel

et al. 2024

IJCEO

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: Retinoblastoma is a childhood malignant intraocular tumor, necessitates a comprehensive treatment approach. Chemotherapy plays a crucial role in managing retinoblastoma. This study aims to evaluate and analyze high-risk histopathological features (HRF) in retinoblastoma cases initially treated with enucleation and those undergoing secondary enucleation after chemotherapy in a tertiary centre in western India.: This retrospective study was carried out in the pathology department, encompassing a total of 136 cases with enucleated eyes, spanning the period from Jan 2017 to Mar 2023. In the present study, all slides were retrieved and examined to gather information on demographics, laterality, choroid invasion, optic nerve invasion, anterior chamber invasion, tumor discrimination, chemotherapy effects, and tumor regression.In this study, the predominant presenting complaint was leukocoria (90%), with a slight female preponderance (53%), in comparison to males (47%). Unilateral cases accounted for 96%, while bilateral presentations were observed in 4% of cases. The mean age was 38 months, with 43% of eyes exhibiting significant choroid invasion and 27% showing invasion beyond the post-laminar optic nerve or resection margin. 76 patients (56%) underwent primary enucleation and 60 (44%) had secondary enucleation after chemotherapy. Out of the 60 patients with secondary enucleation, only 21 patients (35%) had HRF.We found late age of presentation of retinoblastoma in developing country like India. Higher incidence of HRFs in primary enucleated eyes than secondary enucleated eyes. Higher number of cases shows complete regression of tumor after chemotherapy.

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Chemotherapy induced histopathological changes in retinoblastoma, assessment of high risk predictive factors & its correlation with comorbid conditions

Cited by 2 publications

References 14 publications

Survival outcomes of unilateral retinoblastoma based on pathological risk stratification-experience at a tertiary care centre in Pakistan

Survival outcomes of unilateral retinoblastoma based on pathological risk stratification-experience at a tertiary care centre in Pakistan

Evaluation of high risk histopathology features in primary and secondary enucleated retinoblastoma-study of 136 cases in tertiary eye hospital

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