Chemotherapy for Teratoma With Malignant Transformation

Donadio, Alessia; Motzer, Robert J.; Bajorin, Dean F.; Kantoff, Philip W.; Sheinfeld, Joel; Houldsworth, Jane; Chaganti, R. S. K.; Bosl, George J.

doi:10.1200/jco.2003.01.019

Cited by 210 publications

(169 citation statements)

References 13 publications

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the presence of a metastatic STM implies a poor prognosis (2, 3). Nevertheless, Donadio et al (6) showed that systemic chemotherapy may be effective for teratomas with STM limited to a single-cell type. It is recommended that the choice of chemotherapy regimens in such cases should be dictated by the transformed histology rather than the GCT (2, 6).…”

Section: Discussionmentioning

confidence: 99%

“…Unresectable or metastatic settings will generally require multimodal therapy including both chemotherapy and locoregional approaches (6). However, while GCT is sensitive to platinum-based chemotherapy, STM arising from GCT has been traditionally thought to be unresponsive to platinum-based chemotherapy (1).…”

Section: Discussionmentioning

confidence: 99%

“…However, there are no unique clinical characteristics for the diagnosis of a teratoma with STM. Typically, this histology is incidentally found at the time of surgery (6). Thus, an exact pathological diagnosis may be difficult and there is a risk of disease progression if the selected chemotherapy regimens are not effective.…”

Section: B Amentioning

confidence: 99%

See 2 more Smart Citations

Neuroendocrine Carcinoma Arising in a Mediastinal Teratoma with Pulmonary Metastasis: A Case Report and the Chemotherapy Response

Lee

et al. 2015

Intern. Med.

View full text Add to dashboard Cite

Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroendocrine Carcinoma Arising in a Mediastinal Teratoma with Pulmonary Metastasis: A Case Report and the Chemotherapy Response

Lee

et al. 2015

Intern. Med.

View full text Add to dashboard Cite

show abstract

“…4 Donadio et al reported a response to chemotherapy tailored for malignant transformation histology in three of 10 metastatic cases. 5 More recently, Necchi et al have shown a possible efficacy of TGCT-oriented therapy that combined timely surgery for TGCT with malignant transformation components. 6 However, the application of adjuvant chemotherapy for stage I non-seminomatous TGCT with components Fig.…”

Section: Discussionmentioning

confidence: 99%

Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non‐seminomatous germ cell tumor with malignant transformation

Ushida

Koizumi²,

Katoh³

et al. 2012

Int J of Urology

View full text Add to dashboard Cite

Abbreviations & AcronymsAbstract: We report a rare case of stage I non-seminomatous testicular germ cell tumor with malignant transformation. The patient received two cycles of chemotherapy (cisplatin, bleomycin and etoposide) tailored to testicular germ cell tumors as an adjuvant therapy after orchiectomy. However, 22 months later, the patient developed a metastasis in the occipital region that consisted of solely rhabdomyosarcoma through malignant transformation of a teratoma component. This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation.

show abstract

“…Malignant transformation is a rare complication of mature cystic teratomas (19). Carcinoid tumors are rare and have been presented as case reports previously (20,21).…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumor arising in a mature cystic teratoma: A case report

et al. 2015

View full text Add to dashboard Cite

Abstract. Mature cystic teratomas are common benign tumors of the ovary. The most common form of malignant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoactive substances produced by the tumor. A 75-year-old woman suffering from groin pain was admitted to the Faculty of Medicine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7-cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow-up examinations.

show abstract

Chemotherapy for Teratoma With Malignant Transformation

Abstract: Chemotherapy for MT limited to a single cell type may result in major responses and long-term survival in selected patients. Local therapy after chemotherapy is an important component of treatment to achieve maximum response.

Cited by 210 publications

References 13 publications

Neuroendocrine Carcinoma Arising in a Mediastinal Teratoma with Pulmonary Metastasis: A Case Report and the Chemotherapy Response

Neuroendocrine Carcinoma Arising in a Mediastinal Teratoma with Pulmonary Metastasis: A Case Report and the Chemotherapy Response

Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non‐seminomatous germ cell tumor with malignant transformation

Carcinoid tumor arising in a mature cystic teratoma: A case report

Contact Info

Product

Resources

About