Chemotherapy for primary cancer can reduce the risk of head and neck second primary malignancy: a propensity-matched analysis

Xiong, Lei; Yu, Huajiao; Wei, Wei; Wang, Chong; Li, Bo; Liu, Huan; Cheng, Ai-Ling; Li, Delong; Han, Zhengxue; Feng, Zhien

doi:10.1007/s00784-022-04752-y

Cited by 1 publication

(1 citation statement)

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“…The role of chemotherapy has been the focus of multiple clinical trials, whether adjuvant or neoadjuvant therapy [ 49 ]. In a recent propensity-matched analysis conducted by Lei Xiong et al [ 50 ], the risk of second primary head and neck malignancy (SPHNM) in patients with locally advanced OSCC was assessed as an effect of chemotherapy against no chemotherapy. Adopting propensity score matching yields 10.7% and 22.1% for patients who received chemotherapy and did not, respectively, have a 10-year cumulative probability of developing SPHNM.…”

Section: Management Of Second Primary Tumorsmentioning

confidence: 99%

Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature

et al. 2023

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Head and neck cancer is among the top ten cancers worldwide, with most lesions in the oral cavity. Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral malignancies and is a significant public health concern. Patients with OSCC are at increased risk for developing concomitant tumors, especially in the oral cavity, due to widely genetically susceptible mucosa to carcinogenic factors. Based on fulfilling specific criteria, these concomitant tumors can be called second primary tumors (SPTs), which can be further categorized into metachronous and synchronous tumors. This research reviews the literature that investigated the concurrent OSCC with second or multiple primaries to improve understanding of the definition, classification guidelines, and its effect on cancer survival. It also highlights the current investigation methods, the variation of standard treatment approaches due to such a phenomenon, and preventive measures discussed in the literature.

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Section: Management Of Second Primary Tumorsmentioning

confidence: 99%