Chemotherapy for Aggressive Juvenile Nasopharyngeal Angiofibroma

Goepfert, Helmuth; Cangır, Ayten; Lee, Ya-Yen

doi:10.1001/archotol.1985.00800070037002

Cited by 81 publications

(34 citation statements)

References 14 publications

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“…[18] For small intracranial recurrences stereotactic radiosurgery may be an alternative. [23] Goepfert et al [24] recommend chemotherapy for recurrences if further surgery or RT is not recommended. This includes intracranial extension with involvement of vital structures, tumors which receive their major blood supply from intracranial vessels or which recur after major surgery or RT.…”

Section: Discussionmentioning

confidence: 99%

Juvenile nasopharyngeal angiofibroma: A single institution study

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Juvenile nasopharyngeal angiofibroma: A single institution study

et al. 2005

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“…40 Other agents associated with varying success include doxorubicin and decarbazine, 110 doxorubicin, vincristine, dactinomycin, and cyclophosphamide. 42 …”

Section: Juvenile Nasopharyngeal Angiofibromas Of the Middle Cranial mentioning

confidence: 99%

Tumors of the skull base in children: review of tumor types and management strategies

Tsai¹,

Santoreneos²,

Rutka³

2002

FOC

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Although many treatment strategies for skull base tumors in adults have been reported, relatively little has been reported regarding such therapies in the pediatric population. Skull base tumors in children present a therapeutic challenge because of their unique pathological composition, the constraints of the maturing skull and brain, and the small size of the patients. In this review, the authors examine the pediatric skull base lesions that occur in the anterior, middle, and posterior cranial base, focusing on unique pediatric tumors such as encepahalocele, fibrous dysplasia, esthesioneuroblastoma, craniopharyngioma, juvenile nasopharyngeal angiofibroma, cholesteatoma, chordoma, chondrosarcoma, and Ewing sarcoma. They review management strategies that include radio- and chemotherapy, as well as surgical approaches with emphasis on the modifications and complications associated with the procedures as they apply in children. Evidence for the advantages and limitations of radiotherapy, chemotherapy, and surgery as it pertains to the pediatric population will be examined. With a working knowledge of skull base anatomy and special considerations of the developing craniofacial skeleton, neurosurgeons can treat skull base lesions in children with acceptable morbidity and mortality rates. Outcomes in this population may be better than those in adults, in part because of the benign histopathology that frequently affects the pediatric skull base, as well as the plasticity of the maturing nervous system.

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“…It accounts for only 0.05% of all head and neck tumors, although it is noted to be the most common benign tumor originating in the nasopharynx [11], The av erage age of the patient with this tumor is 15 years, and nearly 3% of the reported cases are in females [8]. The most common pre senting symptoms are severe, recurrent epistaxis with persistent nasal obstruction.…”

Section: Introductionmentioning

confidence: 99%

“…These efforts have included surgery, interstitial or external ra diation therapy, chemotherapy, clectroco-agulation, cryosurgery, and hormone admin istration. Surgery and radiation therapy seem to be the most effective treatments, and are the therapies of choice recom mended by most authors [3,8,9,11,15]. Controversy still exists as to how patients with recurrent or residual disease should be treated, and how large tumors at the skull base (with or without intracranial extension) should be managed.…”

Section: Introductionmentioning

confidence: 99%

Juvenile Angiofibromas: A 40-Year Surgical Experience

Amedee¹,

Klaeyle²,

Mann³

et al. 1989

ORL

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A series of 22 patients with histologically confirmed angiofibroma were treated primarily by surgical removal at the University of Freiburg ENT clinic during the 40-year period, 1946–1986. These tumors were staged according to size and extension on the basis of roentgenographic and surgical findings. Specific analysis of the operative approaches and recurrence rate by stage are included. Recurrent or residual disease was handled by surgical excision, irradiation, embolization, or a combination of these methods. The complication and morbidity rates were extremely low, while the mortality rate was zero. The tumor specimens received from the last 5 patients were evaluated for the presence of sex hormone receptors. No specific estrogen, progesterone or androgen receptors were detected in these tissues.

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Chemotherapy for Aggressive Juvenile Nasopharyngeal Angiofibroma

Cited by 81 publications

References 14 publications

Juvenile nasopharyngeal angiofibroma: A single institution study

Juvenile nasopharyngeal angiofibroma: A single institution study

Tumors of the skull base in children: review of tumor types and management strategies

Juvenile Angiofibromas: A 40-Year Surgical Experience

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