Juvenile Angiofibromas: A 40-Year Surgical Experience

Amedee, Ronald G.; Klaeyle, D.; Mann, Wolf J.; Geyer, Helmut

doi:10.1159/000276032

Cited by 12 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improved surgical control rates were largely achieved by improved preoperative evaluation, better surgical support measures such as embolization, and the operators' increasing experience with microscopic and endoscopic techniques. The number of recurrences per patient in this series was 1.8, comparable to the reported rate since 1960 and independent of tumor stage and the approach used for initial tumor removal 1,2 . This was true for treatment of the initial tumor as well as for the recurrent disease.…”

Section: Discussionsupporting

confidence: 76%

“…The number of recurrences per patient in this series was 1.8, comparable to the reported rate since 1960 and independent of tumor stage and the approach used for initial tumor removal. 1,2 This was true for treatment of the initial tumor as well as for the recurrent disease. In two patients, two recurrences were observed, which we were able to control surgically using an endonasal and a midface deglov- ing approach.…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for only 0.5% of all head and neck tumors, it is noted to be the most common benign tumor originating in the nasopharynx, and it has an average age of onset of 15 years 1 . Tumor growth seems to be influenced by hormonal factors, although tumor samples fail to show presence of estrogen, progesterone, or androgen receptors 2 . The most common presenting symptoms are severe, recurrent epistaxis with persistent nasal obstruction.…”

Section: Introductionmentioning

confidence: 99%

“…1 Tumor growth seems to be influenced by hormonal factors, although tumor samples fail to show presence of estrogen, progesterone, or androgen receptors. 2 The most common presenting symptoms are severe, recurrent epistaxis with persistent nasal obstruction. As the disease progresses, facial deformities, proptosis, blindness, and cranial nerve palsies may occur.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Juvenile Angiofibromas: Changing Surgical Concept Over the Last 20 Years

Mann¹,

Jecker²,

Amedee

2004

The Laryngoscope

113

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Juvenile Angiofibromas: Changing Surgical Concept Over the Last 20 Years

Mann¹,

Jecker²,

Amedee

2004

The Laryngoscope

113

View full text Add to dashboard Cite

show abstract

“…A role for androgens in JNA has been proposed but not proven. [1][2][3][4][5] Another influence might be the expression of angiogenic growth factors by the tumor that leads to vessel growth and subsequent tumor proliferation. This hypothesis is supported by a study conducted by Schiff and colleagues 6 in 1992 that documented immunolocalization of basic fibroblast growth factor, a strong proangiogenic cytokine, in the vessel endothelium of JNA.…”

mentioning

confidence: 99%

Vessel Density, Proliferation, and Immunolocalization of Vascular Endothelial Growth Factor in Juvenile Nasopharyngeal Angiofibromas

Brieger¹,

Wierzbicka²,

Sokolov³

et al. 2004

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, highly vascularized neoplasm of the nasopharynx that affects boys and young men. The underlying dysregulated molecular mechanisms remain unclear. The participation of angiogenic growth factors has been suggested, but few studies have been published. Objectives: To evaluate the expression and localization of vascular endothelial growth factor (VEGF), proliferating cells, and vessel density in JNA. Study Design: Immunohistochemical examination of 10 consecutive JNAs (8 primary tumors and 2 recurrent tumors). Methods: Paraffin-embedded and cryopreserved JNA samples were included. VEGF-, CD31-, and Ki67specific antibodies were applied and visualized using light microscopy. Vascularization was determined by counting CD31-positive vessels. Proliferating and VEGFexpressing vessels as well as stromal cells were quantified by the same method. Patients' age at the time of surgery and tumor stage were correlated with the immunohistochemical data. Results: All tumors were heavily vascularized, but major differences were noted between the samples. About half of the vessels were proliferating (Ki67 positive) and half of the Ki67-positive cells were also VEGF positive. The tumor stroma was VEGF positive in 8 of 10 samples and proliferating in 5 of these 8. The 5 samples with both VEGF-and Ki67-positive stroma showed high vessel densities. No correlation was observed between age or tumor stage and vessel density, VEGF expression, or Ki67 expression. Conclusions: In JNA, VEGF is frequently expressed by stromal cells and vessels and is associated with proliferation and increased vessel density. We suggest the promotion of vascularization by VEGF, but the involvement of androgens in JNA angiogenesis still needs to be analyzed.

show abstract

Immunohistochemical analysis of growth mechanisms in juvenile nasopharyngeal angiofibroma

Schuon

Brieger²,

Heinrich³

et al. 2006

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Angiogenic factors are discussed to participate in growth and promotion of juvenile nasopharyngeal angiofibroma (JNA). However, only few data are available and mechanisms remain unclear. In the presented study we analysed the expression and subcellular distribution of several angiogenic growth factors and receptors potentially involved in JNA-growth and -vascularisation. In a retrospective, descriptive, multicenter-study, we analysed 13 formalin-fixed, paraffin-embedded or cryopreserved JNA-tumors (eleven primary tumors and two recurrent ones) after immunohistochemical staining. We used monoclonal antibodies specific for transforming growth factor beta 1 (TGF-beta(1)), basic fibroblast growth factor (bFGF), the VEGF-receptors 1 and -2 (FLT-1 and FLK-1), and the hypoxia inducible factor (Hif-1alpha). Data were compared to the vessel density. Quantitative analysis of staining intensities was performed by a computer assisted quantification technique. Endothelial and stromal compartments of the samples were analysed separately. Data were compared to vessel densities and patients data. The VEGF-Receptor-2 (FLK) was frequently unregulated in the stroma and endothelium of those samples with high vessel densities. Similarly, we observed high bFGF- and TGF-beta(1) levels in the stroma of strong vascularised samples. No correlations of expression levels to patients' data were found. The reported data support the concept of JNA-growth and -vascularisation driven by factors released from stromal fibroblasts. Therefore, inhibition of these factors might be beneficial for the therapy of inoperable JNA.

show abstract

Juvenile Angiofibromas: A 40-Year Surgical Experience

Cited by 12 publications

References 12 publications

Juvenile Angiofibromas: Changing Surgical Concept Over the Last 20 Years

Juvenile Angiofibromas: Changing Surgical Concept Over the Last 20 Years

Vessel Density, Proliferation, and Immunolocalization of Vascular Endothelial Growth Factor in Juvenile Nasopharyngeal Angiofibromas

Immunohistochemical analysis of growth mechanisms in juvenile nasopharyngeal angiofibroma

Contact Info

Product

Resources

About