Chemotherapy by Sulphanilamide Drugs

Browning, C. H.

doi:10.1136/bmj.2.4100.265

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…This antibacterial drug was discovered in 1932 by Bayer's laboratory [71,72] . Prontosil was also proposed to treat systemic disease such as septicemia [73]. The sulphonamide group was recognized as the basic therapeutic part of prontosil, which led to the development of sulphonamide class of drugs [74,75].…”

Section: Antimicrobial and Antiviral Propertiesmentioning

confidence: 99%

Biomedical Applications of Aromatic Azo Compounds

Ali

Hamid

Rashid

2018

MRMC

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Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, azo compounds are reported as antibacterial, antiviral, antifungal and cytotoxic agents. They have the ability to be used as drug carriers, either by acting as a 'cargo' that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery. Besides drug-like and drug carrier properties, a number of azo dyes are used in cellular staining to visualize cellular components and metabolic processes. However, the biological significance of azo compounds, especially in cancer chemotherapy, is still in its infancy. This may be linked to early findings that declared azo compounds as one of the possible causes of cancer and mutagenesis. Currently, researchers are screening the aromatic azo compounds for their potential biomedical use, including cancer diagnosis and therapy. In this review, we highlight the medical applications of azo compounds, particularly related to cancer research. The biomedical significance of cis-trans interchange and negative implications of azo compounds are also discussed in brief.

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Section: Antimicrobial and Antiviral Propertiesmentioning

confidence: 99%

Biomedical Applications of Aromatic Azo Compounds

Ali

Hamid

Rashid

2018

MRMC

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“…Also, the animal body is capable of transforming many compounds which are inactive in vitro to active compounds in vivo, as witness the original Prontosil. The preliminary studies in mice tell almost nothing about the complica- tions which may be encountered in human therapy with the compound, so that, after favorable results have been obtained in mice, it is necessary to conduct very extensive pharmacological and toxicological studies using larger test animals before proceeding to clinical studies. The possible dangers and the means of testing against them have been adequately covered elsewhere (122,139,158,17,128) and do not concern us here.…”

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confidence: 99%