Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development

DePaola, Louis G.; Overholser, C. Daniel; Meiller, Timothy F.; Minah, Glenn E.; Niehaus, Carol

doi:10.1111/j.1600-051x.1989.tb01661.x

Cited by 132 publications

(88 citation statements)

References 19 publications

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“…The present study confirms the antiplaque and antigingivitis efficacy of an EO mouthrinse which has been demonstrated in short-term, 7,8,9 as well as in longer-term studies 6,10,11,12,13 following the ADA guidelines for clinical trials. These studies showed up to 56% greater plaque reduction and up to 34% greater gingivitis reduction than control in subjects with mild-to-moderate plaque and gingivitis.…”

Section: Discussionsupporting

confidence: 88%

“…An essential oil-containing mouthrinse (EO) has demonstrated significant antiplaque and antigingivitis efficacy in short-term 7,8,9 and long-term clinical studies 6,10,11,12,13 designed within the guidelines required by the American Dental Association Council on Scientific Affairs for evaluating the clinical efficacy of chemotherapeutic mouthrinses.…”

Section: Introductionmentioning

confidence: 99%

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Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week randomized clinical trial

Amini¹,

Araujo

et al. 2009

Braz. oral res.

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The objective of this randomized, examiner blind, parallel group, controlled clinical trial was to compare the antiplaque and antigingivitis efficacy of an essential oil-containing mouthrinse (EO) to two mouthrinses containing 0.05% Cetylpyridinium Chloride (CPC), one with alcohol and one alcohol-free, using a two-week experimental gingivitis validated-model with a 5% hydroalcohol rinse serving as the negative control. One hundred and fifty-nine subjects, 56 males and 103 females; ranging in age from 18 to 58 years in good general health were assigned to one of the four treatment groups: EO (n = 40), 0.05% CPC with alcohol (CPC a , n = 39), 0.05% CPC alcohol-free (CPC na , n = 40), and 5% hydroalcohol negative control (n = 40). The Mean Turesky Modification of the Quigley-Hein Plaque Index (PI) and the Mean Modified Gingival Index (MGI) were the primary efficacy endpoints and were evaluated at baseline and at two weeks. Following baseline examinations, subjects received a complete dental prophylaxis and began supervised rinsing with their assigned mouthrinse twice daily for two weeks, as their sole oral hygiene measure; 151 subjects completed the trial. Two weeks after baseline the EO adjusted mean PI and MGI scores were significantly lower than those of both CPC rinses and negative control (p < 0.001). In conclusion, the EO mouthrinse demonstrated significantly greater antiplaque and antigingivitis efficacy than both CPC-containing mouthrinses and the negative control.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week randomized clinical trial

Amini¹,

Araujo

et al. 2009

Braz. oral res.

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“…25 This fixed combination EOs mouthrinse containing 0.064% thymol, 0.092% eucalyptol, 0.060% methyl salicylate, and 0.042% menthol has been previously shown to be an effective antiplaque/antigingivitis product in numerous six-month clinical trials. [2][3][4][5][6][7][8][20][21] The experimental gingivitis model used for this study, in which subjects abstain from all mechanical oral hygiene procedures for the two-week study period, 11 provides a rigorous test for antiplaque/antigingivitis products and enables a determination to be made of relative chemotherapeutic effectiveness against the dental plaque biofilm in situ.…”

Section: Discussionmentioning

confidence: 99%

“…1 A mouthrinse containing a fixed combination of essential oils (Listerine  Antiseptic, Morris Plains, USA) has been shown in a number of six-month clinical trials [2][3][4][5][6][7][8] to have significant antiplaque and antigingivitis efficacy. Efficacy has been acknowledged through ADA acceptance 9 and a Category I recommendation, i.e., safe and effective, by a U.S. FDA advisory panel reviewing antiplaque products for the control of gingivitis.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

et al. 2011

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Two antimicrobial agents, a fixed combination of essential oils (EOs) and 0.07% cetylpyridinium chloride (CPC) are found in commercially available mouthrinses, Listerine  Antiseptic and Crest  Pro Health  , respectively. Both mouthrinses have been shown to control dental plaque and gingivitis in short and longer term studies. The aim of this study was to determine the comparative effectiveness of these two mouthrinses using a 2-week experimental gingivitis model. Qualified subjects were randomly assigned to one of three mouthrinse groups: a fixed combination of EOs, 0.07% CPC, or negative control (C) rinse. Following baseline clinical assessments and a dental prophylaxis, subjects began a two-week period in which they rinsed twice daily with their assigned rinse and abstained from any mechanical oral hygiene procedures or other oral care products. Subjects were reassessed at the end of the two-week period. One hundred and forty-seven subjects were randomized and 142 completed this study. After two weeks use, the EOs rinse was superior (p ≤ 0.011) to the CPC rinse in inhibiting the development of gingivitis, plaque, and bleeding, with 9.4% and 6.6% reductions compared to CPC for gingivitis and plaque, respectively. Both rinses were superior to the negative control rinse (p < 0.001). This study demonstrates that the essential oil-containing mouthrinse has superior antiplaque/antigingivitis effectiveness compared to the 0.07% CPC-containing mouthrinse without mechanical oral hygiene influence.

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“…Most adults brush and floss inadequately, and constant education and/or reinforcement are often required [21]. Bacteria are usually left behind with mechanical oral health routines, and chemotherapeutic agents may have a key role as adjuncts to daily home-care.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Clinical Efficacy of Chlorhexidine, Phenolic and Chitosan Mouthrinses on Plaque and Gingivitis: Single-Centre, Double Blind, Randomized Controlled Clinical Study

HP¹

2017

Austin J Dent

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The present study was conducted to determine the effect of different mouthwash preparations used as supplement to regular oral hygiene measures on plaque and gingivitis.A total of 40 patients with chronic gingivitis demonstrating good oral hygiene were recruited for the study and divided into 4 groups. The subjects were briefed about the nature of the study and informed consents were taken. 4 different mouthwash preparations were given among the 4 groups. They are chlorhexidine digluconate, phenolic (Essential oil), chitosan anti-adhesive mouthwash and placebo (distilled water) for the control group. Clinical parameters including gingival index (Loe-Silness, 1963), plaque index (Turesky modification of Quigley-Hein, 1970) and stain index (Lobene, 1968) were recorded at baseline, 3 weeks and 6 weeks for all 4 groups.Results showed that there is highly statistically significant decrease in plaque and gingival index in chlorhexidine and Essential oil group, statistically significant decrease in chitosan and placebo group. Findings from this study indicate chlorhexidine to be the most effective anti-plaque and anti-gingivitis agent, followed by Essential oil mouthwash with the benefit of reduced staining, thus can be used on long term basis, and whereas chitosan is not significantly effective compared to placebo group.

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Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development

Cited by 132 publications

References 19 publications

Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week randomized clinical trial

Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week randomized clinical trial

Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

Comparative Evaluation of Clinical Efficacy of Chlorhexidine, Phenolic and Chitosan Mouthrinses on Plaque and Gingivitis: Single-Centre, Double Blind, Randomized Controlled Clinical Study

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