Abstract:The disodium salt of quinacillin (3-carboxy-2-quinoxalinylpenicillin) is highly effective in protecting mice experimentally infected with penicillin-sensitive or penicillinase-producing strains of Staph. aureus. Like other penicillinase-resistant penicillins, it is very much less effective against infections initiated with methicillin-resistant strains obtained from clinical sources. Quinacillin is not toxic to laboratory animals except when large doses are repeatedly administered to rabbits; under these condi… Show more
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