Chemotaxonomic study of the genusTabernaemontana (Apocynaceae) based on their indole alkaloid content

Zhu, Jiping; Guggisberg, Armin; Kalt-Hadamowsky, M.; Hesse, Manfred

doi:10.1007/bf00937795

Cited by 17 publications

(7 citation statements)

References 92 publications

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“…Although the "Ambelanieae" and "Macoubeeae" have a syncarpous ovary and seeds embedded in pulp, whereas in the Tabemaemontaneae the ovary is usually apocarpous and the seeds displayed with (often brightly colored) arils, the close relationship of these three tribes is well supported by morphological, chemical, and molecular evidence (Fallen, 1986;Zhu et al, 1990;Endress et al, 1996;Sennblad & Bremer, 1996;Sennblad, 1997;Civeyrel et al, 1998). Therefore, all are included here in a more broadly circumscribed Tabernaemontaneae.…”

Section: A Infrafamilial Classification Of the Apocynaceae Sstrmentioning

confidence: 96%

A revised classification of the Apocynaceae s.l.

2000

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Section: A Infrafamilial Classification Of the Apocynaceae Sstrmentioning

confidence: 96%

A revised classification of the Apocynaceae s.l.

2000

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“…They also transferred Leeuwenberg's Ambelanieae and Macoubeeae to Tabernaemontaneae because of the lignified guide rails of their anthers. This placement is supported by morphological, molecular and chemical evidence (Fallen, ; Zhu et al ., ; Endress et al ., ; Sennblad & Bremer, , ; Sennblad, ; Civeyrel et al ., ; Potgieter & Albert, ). Likewise, Plumerieae sensu Leeuwenberg are dispersed into Plumerieae, Melodineae and Vinceae.…”

Section: Rauvolfioideaementioning

confidence: 99%

The taxonomy and systematics of Apocynaceae: where we stand in 2012

et al. 2013

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In their most recent classification of Apocynaceae in 2000, Endress and Bruyns recognized five subfamilies of Apocynaceae (Rauvolfioideae, Apocynoideae, Periplocoideae, Secamonoideae and Asclepiadoideae). Subsequently, through various studies using molecular data, it has been shown that most tribes and subtribes of Rauvolfioideae were not monophyletic, and new tribes and subtribes have been erected to reflect improved phylogenetic understanding of the family: Aspidospermeae in Rauvolfioideae; Nerieae, Odontadenieae and Baisseeae in Apocynoideae; Fockeeae in Asclepiadoideae; and Orthosiinae in Asclepiadeae. Several genera in Rauvolfioideae have been reassigned to different tribes in order to improve the monophyly of these tribes. The sister group of Asclepiadoideae plus Secamonoideae is not Periplocoideae, as formerly assumed, but tribe Baisseeae. Periplocoideae are nested in Apocynoideae. However, tribal composition remains unclear in some parts of the family. Clade structure in Apocynaceae is now generally well understood. The principal challenges now lie in identifying characters that can reflect and articulate these clades in a formal classification. Species‐rich, recent radiations such as core Asclepiadinae in Africa and the Metastematinae in Latin America present particular problems in this regard. © 2013 The Linnean Society of London

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“…These alkaloids, which are structurally diverse, are commonly found in many members of the genus and are considered chemotaxonomically important (Zhu et al, 1990). To date, over 300 of these alkaloids have been isolated (Cardoso et al, 1998).…”

Section: It Has Been Over 60 Years Since the First Strains Of Methicimentioning

confidence: 99%

Effect of an alkaloidal fraction of Tabernaemontana elegans (Stapf.) on selected micro-organisms

Pallant

Cromarty

Steenkamp

2012

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Bacterial infections remain a significant threat to human health. Due to the emergence of widespread antibiotic resistance, development of novel antibiotics is required in order to ensure that effective treatment remains available. There are several reports on the ethnomedical use of Tabernaemontana elegans pertaining to antibacterial activity.Aim of the study: The aim of this study was to isolate and identify the fraction responsible for the antimicrobial activity in T. elegans (Stapf.) root extracts. Materials and methods:The active fraction was characterised by thin layer chromatography (TLC) and gas chromatography -mass spectrometry (GC-MS).Antibacterial activity was determined using the broth micro-dilution assay and antimycobacterial activity using the BACTEC radiometric assay. Cytotoxicity of the crude extract and fractions was assessed against primary cell cultures; lymphocytes and fibroblasts; as well as a hepatocarcinoma (HepG2) and macrophage (THP-1) cell line using the Neutral Red uptake and MTT assays. Results:The crude root extracts were found to contain a high concentration of alkaloids (1.2% w/w). GC-MS analysis identified the indole alkaloids, voacangine and dregamine, as major components. Antibacterial activity was limited to the Grampositive bacteria and Mycobacterium species, with MIC values in the range of 64 -256 μg/ml. When combined with antibiotics, additive antibacterial effects were observed. Marked cytotoxicity to all cell lines tested was evident in the MTT and Neutral Red uptake assays, with IC 50 values < 9.81 μg/ml. 3Conclusions: This study confirms the antibacterial activity of T. elegans and supports its potential for being investigated further for the development of a novel antibacterial compound.

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Chemotaxonomic study of the genusTabernaemontana (Apocynaceae) based on their indole alkaloid content

Cited by 17 publications

References 92 publications

A revised classification of the Apocynaceae s.l.

A revised classification of the Apocynaceae s.l.

The taxonomy and systematics of Apocynaceae: where we stand in 2012

Effect of an alkaloidal fraction of Tabernaemontana elegans (Stapf.) on selected micro-organisms

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