Chemotactic Arrangement of Axons Inside and Distal to a Venous Graft

Brunelli, G; Fontana, Gregory P.; Jäger, Christoph; Bartolaminelli, P.; Franchini, A

doi:10.1055/s-2007-1006969

Cited by 17 publications

(7 citation statements)

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“…In a further experiment, in 1987, they were able to demonstrate the selective chemotactic attraction for sensory and motor nerve fibres across an autologous vein graft shorter than 1 cm. 13 Selective chemotaxis was further demonstrated by &hi et al l4 and Maki.'' In 1984, Ide16 showed the possibility of using the basal lamina scaffold of the skeletal muscle to guide nerve regeneration.…”

Section: History Of Nerve Conduitsmentioning

confidence: 89%

“…In a further experiment, in 1987, they were able to demonstrate the selective chemotactic attraction for sensory and motor nerve fibres across an autologous vein graft shorter than 1 cm. 13 Selective chemotaxis was further demonstrated by &hi et al Mackinnon and DellonZ6 reported on nerve regeneration stumps of the damaged nerve; 3) contain all along its length substances exerting chemotactic attraction and giving a substratum for axonal progression, and 4) protect the regenerating axons against scar invasion. At present there are a number of problems associated with biological or biodegradable tubes: 1) the collapse of the tubes (especially veins) if the gap is too large, 2) the danger of early partial reabsorption with scar invasion, 3) the lack of chemotactic attraction for distances greater than 8-10 mm, and 4) the difficulty in matching muscle fibres with nerve fascicles at proximal and distal ends with loss of axons, when using fresh or predegenerated muscle.…”

Section: History Of Nerve Conduitsmentioning

confidence: 91%

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Invited review: Different conduits in peripheral nerve surgery

Vigasio

Brunelli

1994

Microsurgery

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A considerable amount of research is being undertaken regarding the possibility of bridging loss of nerve substance with different guiding tubes, in order to improve functional outcome, reduce the surgical time, and reduce damage at donor nerve sites. A review of the literature and personal research allows us to state that: for short gaps, biological tubes (autologous veins) may give good results and also allow chemotactic attraction with selective arrangements of motor and sensory axons. Gaps longer than 1 cm do not allow tropism and are associated with failure to support axonal regrowth. Artificial biodegradable conduits still show results that are controversial; they may give good results provided that the material of which they are made is perfectly tolerated. Empty tubes, longer than 8-10 mm, besides being deprived of the chemotactic attraction, may collapse or be partially reabsorbed and replaced by scar. Probably in the near future biological or biodegradable tubes, containing laminin-like substances or muscle scaffold, will allow us to bridge increasingly large defects in nerves.

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“…In a further experiment, in 1987, they were able to demonstrate the selective chemotactic attraction for sensory and motor nerve fibres across an autologous vein graft shorter than 1 cm. 13 Selective chemotaxis was further demonstrated by &hi et al l4 and Maki.'' In 1984, Ide16 showed the possibility of using the basal lamina scaffold of the skeletal muscle to guide nerve regeneration.…”

Section: History Of Nerve Conduitsmentioning

confidence: 89%

“…In a further experiment, in 1987, they were able to demonstrate the selective chemotactic attraction for sensory and motor nerve fibres across an autologous vein graft shorter than 1 cm. 13 Selective chemotaxis was further demonstrated by &hi et al Mackinnon and DellonZ6 reported on nerve regeneration stumps of the damaged nerve; 3) contain all along its length substances exerting chemotactic attraction and giving a substratum for axonal progression, and 4) protect the regenerating axons against scar invasion. At present there are a number of problems associated with biological or biodegradable tubes: 1) the collapse of the tubes (especially veins) if the gap is too large, 2) the danger of early partial reabsorption with scar invasion, 3) the lack of chemotactic attraction for distances greater than 8-10 mm, and 4) the difficulty in matching muscle fibres with nerve fascicles at proximal and distal ends with loss of axons, when using fresh or predegenerated muscle.…”

Section: History Of Nerve Conduitsmentioning

confidence: 91%

Invited review: Different conduits in peripheral nerve surgery

Vigasio

Brunelli

1994

Microsurgery

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“…Although autogenous nerve grafting is still considered the best current method for bridging peripheral nerve lesions with substance defect (Terzis et al 1997), several other grafting conduits (i.e., biological or synthetic tubes) have been studied experimentally for nerve repair (Lundborg et al 1981;Glasby et al 1986;Jimming et al 1986;Brunelli et al 1987;Rich et al 1989;Mackinnon and Dellon 1990;Chen et al 1994;Ansselin et al 1997). Previous studies showed that a new surgical procedure, named muscle-vein-combined grafting technique, could give very good results even for the repair of longdistance nerve defects (Brunelli et al 1993;Battiston et al 2000a,b).…”

Section: Introductionmentioning

confidence: 99%

Morphological analysis of peripheral nerve regenerated by means of vein grafts filled with fresh skeletal muscle

Geuna

Tos²,

Battiston³

et al. 2000

Anatomy and Embryology

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Clinical data have shown that a vein segment filled with fresh skeletal muscle can be considered a good autologous grafting conduit for the repair of peripheral nerve lesions. In this study, the long-term morphological organization of rat sciatic nerve fibers regenerated along a muscle-vein-combined graft conduit is further analysed by light and electron microscopy. Regenerated nerve fibers were organized into fascicles of various sizes that were clearly delimited by perineurial-like shells made by long and thin cytoplasmic processes of perineurial-like bipolar cells and by densely packed collagen fibrils. Grafted skeletal muscle fibers were still detectable among nerve fiber fascicles. However, in spite of the persistence of skeletal muscle along the graft, regenerated nerve fibers showed a good morphological pattern of regeneration, providing further evidence that the muscle-vein-combined grafting technique represents an effective surgical alternative to the classical fresh nerve autograft for the repair of peripheral nerve defects.

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“…7 After a long silence, it was reintroduced by a series of reports using the chamber models to examine axonal regeneration in an enclosed space, [8][9][10][11][12][13][14][15] including the concept of chemotaxis described by Cajal. 16 Since then, many experimental trials were done to examine the effects of prosthetic tubulization with a short gap on enhancing the selectivity of reinnervation, with positive [17][18][19][20][21][22][23] and negative 24,25 results.…”

mentioning

confidence: 99%

Effect of conduit repair on aberrant motor axon growth within the nerve graft in rats

et al. 2007

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After peripheral nerve injury, minimizing axonal misdirection has been a matter of importance to obtain good functional outcomes. In general, it becomes more challenging as the nerve defect length is longer. As previous works suggested that a conduit repair leaving a short gap could induce some target-specific reinnervation, we expected that a distally placed conduit combined with nerve graft would enhance the specificity of reinnervation, especially in dealing with a long gap. To test this, a 14-mm-long gap was created in the rat sciatic nerves and repaired with either 1) whole nerve graft (WG), 2) interfascicular nerve grafts (FG), or 3) whole nerve graft combined with distally placed silicone tube leaving a 5-mm gap (TUBG). At the end of follow up, the extent of target specific reinnervation (measurement of the compound muscle action potentials evoked by stimulation of the sciatic nerve and its tibial and common peroneal fascicles) and the accuracy of motoneuronal projection (sequential retrograde labeling of the common peroneal motor pool) were assessed. Both assessments revealed that groups FG and TUBG had a similar selectivity, which was significantly higher than in group WG. Consistent with these results, the functional recovery as assessed by walking track analysis showed no significant difference between groups FG and TUBG, whereas those were significantly superior to group WG. In contrast, histomorphometric assessment of the regenerating axons and wet muscle weight showed no significant difference among the three groups. In conclusion, conduit repair would have some effects on reducing motor axonal misdirection, and it might be more effective when used in the management of a large defect in combination with nerve graft.

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Chemotactic Arrangement of Axons Inside and Distal to a Venous Graft

Cited by 17 publications

References 0 publications

Invited review: Different conduits in peripheral nerve surgery

Invited review: Different conduits in peripheral nerve surgery

Morphological analysis of peripheral nerve regenerated by means of vein grafts filled with fresh skeletal muscle

Effect of conduit repair on aberrant motor axon growth within the nerve graft in rats

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