Chemosensitization of Carmustine with Maitake β-Glucan on Androgen-Independent Prostatic Cancer Cells: Involvement of Glyoxalase I

Finkelstein, Michael P.; Aynehchi, Shahrad; Samadi, Albert A.; Drinis, Sophia; Choudhury, Muhammad; Tazaki, Hiroshi; Konno, Sensuke

doi:10.1089/107555302320825084

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…This group found that glucan administration increased suppression of tumor growth, apoptosis and antitumor response. Similar observations were found by others [14,15]. In different types of cancer, treatment with glucan and melatonin (individually or together) inhibited progression of adenocarcinoma [16].…”

Section: Discussionsupporting

confidence: 90%

Effects of β-glucans on benign hyperplasia of prostate

Větvička¹,

Richter²,

Vlastimil³

et al. 2014

Pathol Discov

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Background: The stimulation of immune reactions represents a well-established effect of glucan. However, very little is known about the effects on prostate. In this report, we focused on patients with benign hyperplasia of prostate and evaluated the effects of glucan supplementation. Methods: We measured the level of CRP, levels of total (tPSA) and free PSA (fPSA) and number of NK cells. Results: We found positive effects on both NK cell numbers and on the PSA index, suggesting positive effects of glucan supplementation. Our data are further supported by a case report. Conclusions: Our study offers preliminary results supporting the hypothesis that oral administration of glucan has positive effects in patients suffering from benign prostate hyperplasia. Our conclusion is supported by the case report showing significant effects with longer supplementation and higher dose.

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Section: Discussionsupporting

confidence: 90%

Effects of β-glucans on benign hyperplasia of prostate

Větvička¹,

Richter²,

Vlastimil³

et al. 2014

Pathol Discov

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“…An acid-treated fraction (ATF) of Agaricus blazei extract directly inhibited tumor growth by inducing apoptotic processing in Balb/C mice (25). However, this result was later contradicted by another research study which demonstrated that ß-glucan from maitake mushrooms was only active for PC-3 cells in combination with carmustine (BCNU), an anticancer agent (27). ß-glucan obtained from maitake mushroom induced >90% cytotoxic cell death in PC-3 cells at 480 μg/ml in 24-h treatment (26).…”

Section: Discussionmentioning

confidence: 99%

In vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independent human breast cancer cells by selected mushroom species

Gu¹,

Leonard²

2006

Oncol Rep

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Breast cancer is the most commonly diagnosed cancer among women in Western countries. Currently, there is no effective therapy for malignant estrogen-independent breast cancer. We have screened 38 species of edible mushroom on human estrogen-receptor positive (MCF-7) and estrogenreceptor negative (MDA-MB-231, BT-20) breast cancer cells to select potential agents with broad-spectrum antitumor activity against breast cancer cells. Water-based extracts of three mushroom species, Coprinellus sp., Coprinus comatus, Flammulina velutipes (CME, CCE and FVE respectively), were identified as novel anti-breast cancer agents. The antitumor activities include: 1) marked growth inhibition of both ER + and ERbreast cancer cells; 2) induction of rapid apoptosis on both ER + and ERcells; 3) significant inhibition of MCF-7 tumor colony formation in vitro. The antiproliferative and cytotoxic activities of the three mushroom extracts were dose-dependent, regardless of the hormone receptor status of the cancer cells. The degree of produced cytotoxicity on ERbreast cancer cells was very high, while the IC 50 of mushroom extract CME was found to be as low as 40 μg/ml on MDA-MB-231 cells and the IC 50 of mushroom extract FVE was only 30 μg/ml on BT-20 cells. More interestingly, mushroom extracts CME and FVE induced an exceptionally rapid apoptosis on MCF-7 and MDA-MB-231 detected by Annexin V-FITC within 2 h of treatment and DNA fragment endlabeling assay (TUNEL) in 5 h of treatment. Anchorageindependent growth assays indicated that the MCF-7 tumor colony formation rate was reduced by 60% in CCE-and CME-treated cells and nearly completely inhibited (99%) by FVE treatment. These results suggest that mushroom species Coprinus comatus, Coprinellus sp. and Flammulina velutipes contain potent antitumor compounds for breast cancer. Our finding is important due to the lack of chemotherapeutic and chemopreventive agents for ERhuman breast cancer.

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“…10 A separate study also demonstrated a chemosensitizing effect of D-fraction, in which the cytotoxic effect of the anticancer agent carmustine, was significantly enhanced in combination with Dfraction, resulting in ~90-percent cell viability reduction (cell death). 11 These results suggest that the D-fraction may be an alternative treatment modality for prostate cancer and may also work cooperatively with ongoing chemotherapy.…”

Section: Maitake D-fractionmentioning

confidence: 89%