Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina

Abstract

Two new compounds, named (Z)-7,4'-dimethoxy-6-hydroxyaurone-4-O-β-glucopyranoside (1) and ()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid (2), were isolated from the endophytic fungus Penicillium citrinum of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 2 exhibited potent chemoreversal activity, mainly by inhibiting P-glycoprotein efflux pump function.

Molecular Phylogenetics and Biological Potential of Fungal Endophytes From Plants of the Sundarbans Mangrove

“…Fungal endophytes have already been reported in Avicennia alba (Lee et al, 2019) and in A. marina (Bhimba et al, 2012;Basheer et al, 2018;Bibi et al, 2020). Penicillium citrinum was reported in the latter (Liu J. et al, 2015). However, this is the first report of the isolation of Penicillium citrinum and Aspergillus fumigatus from A. alba and A. marina, respectively.…”

Arohynapene A Produced by <i>Penicillium steckii</i> JB-NW-2-1 Isolated from <i>Avicennia marina</i> (Forssk.) Vierh and Its Cytotoxic Activities

“…Since mangrove plants produce secondary metabolites that are chemically unique and diverse, mangrove-derived endophytes are expected to produce a variety of structurally unique and pharmacologically active metabolites. Chemical investigation of mangrove endophytes has revealed the existence of several bioactive secondary metabolites with a variety of structural features, including alkaloids, terpenoids, chromones, coumarins, polyketides, and peptides [7][8].…”