Chemoradiation Related Acute Morbidity in Carcinoma Cervix and Correlation with Hematologic Toxicity: A South Indian Prospective Study

Abstract

Purpose: To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage. The toxicities were most severe in 3 rd and 5 th week. All women could complete radiotherapy except two due to causes unrelated to radiation morbidity; seven (8.86%) had to discontinue chemotherapy due to leukopenia and intractable diarrhea. Though there was no correlation between anemia and other toxicities, it was found that all with leukopenia had diarrhea. Conclusions: Chemoradiation for cancer cervix is on the whole well tolerated. Leukopenia and severe diarrhea were the acute toxicities that compelled discontinuation of chemotherapy in two women. Though anemia had no correlation with gastrointestinal toxicity, all of those with leukopenia had diarrhea. is any correlation between hematologic toxicity and organ system specific toxicity. Keywords

Impact of Treatment Time on Chemoradiotherapy in Locally Advanced Cervical Carcinoma

“…The grade 3 or higher toxicities was also comparable to the conventional treatment arm inspite of significantly shorter overall treatment duration. The rate of grade ≥ 3 toxicity in our study arm is less when compared to other series from our country 25% vs 16% (Kumaran et al, 2014) and equivalent to other contemporary series (Song et al, 2013). Shorter duration of treatment did not result in higher toxicity which is in contrary to the finding by other study (Erridge et al, 2002).The possible explanation of our finding could be due to conventional fraction size practiced in the study.…”

Tolerance of combined radiochemotherapy in cervical cancer patients

“…Only the intensification of post-radiation reaction from the lower gastrointestinal tract and diarrhea were statistically positively significant in correlation with age (relatively p = 0.0120, r = 0.19 and p = 0.0150, r = 0. 19). No relationships between other parameters of post-radiation reaction and the patients' age were observed.…”

“…[3][4][5][6][7] Meta-analyses published later confirmed the results showing the improvement of total survivals by 10-12% and symptomless survivals by 13-16%. [15][16][17][18][19] It is estimated that before publishing these results radiochemotherapy was applied in less than 30% of the patients, and after 1999 this number increased to over 60%. 20 The improvement of survivals in the groups with radiochemotherapy was related to the intensification of post-radiation reactions from gastrointestinal and urinary tracts and especially to hematological reaction.…”

“…20 The improvement of survivals in the groups with radiochemotherapy was related to the intensification of post-radiation reactions from gastrointestinal and urinary tracts and especially to hematological reaction. [3][4][5][6][7][15][16][17][18][19]21 Detailed data related to post-radiation reactions in the research mentioned above, meta-analyses and their comparison to own results are presented in Tables 6 and 7.…”

Assessing Activity Limitation Among Cancer Survivors in Korea Using Data from a Nationwide Survey

“…Structural or functional changes resulting from surgical procedures might lead to activity limitation of cancer patients. Cytotoxicity or adverse effects of chemo/radiotherapy could result in organ systems changes (Kumaran et al, 2014). Along with improved prognosis, the incidence of late effects of cancer treatment will increase during the survivor's life expectancy (Geenen et al, 2007).…”