Chemoprotective role of ethanol extract of Urtica urens L. against the toxicity of imidacloprid on endocrine disruption and ovarian morphometric in female rats, GC/MS analysis

Mzid, Massara; Ghlissi, Zohra; Salem, Maryem Ben; Khedir, Sameh Ben; Chaabouni, Khansa; Ayedi, Fatma; Sahnoun, Zouheir; Hakim, Ahmed; Rebaï, Tarek

doi:10.1016/j.biopha.2017.10.150

Cited by 15 publications

(15 citation statements)

References 40 publications

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“…Kasson et al found that nicotine and its agonists exert an inhibitory effect on the 17-alpha hydroxylase, therefore preventing the conversion of pregnenolone and progesterone into androstenedione, thereby inhibiting ovarian estradiol synthesis [33] . This detrimental effect of IMI on estradiol production has been previously reported [15] , [34] . Results from vitamin E, clomiphene citrate and plant extracts groups may arise from their capacity to counter the oxidative stress, thereby preventing ovarian cells toxicity [18] .…”

Section: Discussionsupporting

confidence: 64%

“…Phytotherapy is nowadays encouraged in the management of reproductive dysfunctions, due to its fewer side effects, accessibility and diversity of its active components [14] . Previous studies have reported the effectiveness of some medicinal plants such as Urtica urens in preventing IMI-induced reproductive toxicity in female rats [15] .…”

Section: Introductionmentioning

confidence: 99%

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The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats

et al. 2022

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats

et al. 2022

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“…Ovalbumin-induced inflammation 28385108 [20] Rats Ischaemia and reperfusion model 27389487 [21] Rats Carbon tetrachloride-treated rats 16425366 [22] In-vitro assay DPPH scavenging activities 26788318 [23] Rats Imidacloprid on endocrine disruption and ovarian morphometric 29091903 [24] [25] Anti-rheumatic effect Human chondrocyte cells IL-1beta treatment 11962753 [26] Anti-viral effect BHK-21 cell line Dengue virus serotype 2 29548293 [27] Feline kidney Crandell cells Feline immunodeficiency virus 15814267 [28] Anti-bacterial effect In vitro assay DPPH, ABTS, β-carotene, and FRAP scavenging activities 28084125 [29] Against food spoiling Bacillus pumilus, Shigella spp. and Enterococcus gallinarum,…”

Section: Ratsmentioning

confidence: 99%

Section: Ratsmentioning

confidence: 99%

Inhibitory Effects of Urtica thunbergiana Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice

et al. 2020

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Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. Urtica thunbergiana (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo, and can be a useful anti-AD agent.

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“…At present, the instrument-based methods, such as high-performance liquid chromatography (HPLC) (Carretero et al, 2003;Saeedeh et al, 2020) and gas chromatography-tandem mass spectrometry (Su et al, 2017;Massara et al, 2018), have been widely used for the determination of IMI. Compared with instrument, immunoassay, as a rapid detection technique, has been widely used for the detection of small molecules due to its advantages in simplicity, specificity, low consumption, and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Development of Fluorescence Polarization Immunoassay for Imidacloprid in Environmental and Agricultural Samples

et al. 2020

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A fluorescence polarization immunoassay (FPIA) for the determination of imidacloprid (IMI) was developed with advantages of simple operation and short assay time. The haptens of IMI, acetamiprid (ACE), and thiamethoxam (THI) were conjugated with fluorescein isothiocyanate ethylenediamine (EDF) and 4′-Aminomethyl fluorescein (AMF), respectively, to prepare six fluorescence tracers. The conjugation of IMI hapten and EDF (IMI-EDF) was selected to develop the FPIA due to the largest fluorescent polarization value increase in the presence of anti-IMI monoclonal antibody. Under the optimum condition, the limit of detection, 50% inhibition concentration and detection range of the FPIA were 1.7, 4.8, and 1.7–16.3 μg/L, respectively. The cross-reactivities (CRs) with the analogs of IMI were negligible except for imidaclothiz with CR of 79.13%. The average recovery of spiked paddy water, corn and cucumber samples were 82.4–118.5% with the RSDs of 7.0–15.9%, which indicated the FPIA had good accuracy. Thus, the developed FPIA was a potential tool for the rapid and accurate determination of IMI in agricultural and environmental samples.

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Chemoprotective role of ethanol extract of Urtica urens L. against the toxicity of imidacloprid on endocrine disruption and ovarian morphometric in female rats, GC/MS analysis

Cited by 15 publications

References 40 publications

The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats

The edible plant Amaranthus hybridus (Amaranthaceae) prevents the biochemical, histopathological and fertility impairments in colibri®-treated female rats

Inhibitory Effects of Urtica thunbergiana Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice

Development of Fluorescence Polarization Immunoassay for Imidacloprid in Environmental and Agricultural Samples

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