Chemopreventive Potential of Myrtenal against Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis

Farrag, Mostafa A; Ezz, Magda K.; Ibrahim, Nashwa K; Ahmed, Emad K.

doi:10.1080/01635581.2021.1879881

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…The downregulation in the expressions of COX-2, NF- κ B, and STAT-3 correlated with the suppression of the levels of inflammatory cytokines of TNF- α and IL-6 and biomarkers of oxidative damage (MDA and NO). In addition, a significant increase in caspase-A3 activity and Bax/Bcl-2 ratio indicate that the anti-inflammatory effect and the induction of apoptosis contributed to this activity [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

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Monoterpenes are a group of natural products that have been widely studied due to their therapeutic potential against various pathologies. These compounds are abundant in the chemical composition of essential oils. Cancer is a term that covers more than 100 different types of malignant diseases and is among the leading causes of death in the world. Therefore, the search for new pharmacotherapeutic options applicable to cancer is urgent. In this review, studies on the antitumor activity of monoterpenes found in essential oils were selected, and botanical, chemical, and pharmacological aspects were discussed. The most investigated monoterpenes were carvacrol and linalool with highly significant in vitro and in vivo tumor inhibition in several types of cancers. The action mechanisms of these natural products are also presented and are wildly varied being apoptosis the most prevalent followed by cell cycle impairment, ROS production, autophagy, necroptosis, and others. The studies reported here confirm the antitumor properties of monoterpenes and their anticancer potential against various types of tumors, as demonstrated in in vitro and in vivo studies using various types of cancer cells and tumors in animal models. The data described serve as a reference for the advancement in the mechanistic studies of these compounds and in the preparation of synthetic derivatives or analogues with a better antitumor profile.

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Section: Resultsmentioning

confidence: 99%

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

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“…[ 102 ] This specific property helps in preventing cancer growth in the initiation phase itself and proved in experimental studies to inhibit post translational modification of cellular proteins by modulating oncogenes and tumour suppressor genes through signal transduction. [ 103 ] The authors have well documented the effect of myrtenal that decreased expression of Cox 2 in bladder cancer, [ 32 ] which in turn, decreased the levels of prostaglandin PGE2 and PGF2, the same phenomenon was noted in pancreatic cancer induced transgenic mice which targeted STAT3/NFkB/COX‐2 signalling pathway to obtain a promising outbreak in cancer treatment. [ 104 ]…”

Section: Myrtenalmentioning

confidence: 89%

“…In vivo Wistar rats [32] Oral cancer Biological activity of myrtenal can be enhanced by targeted drug delivery systems such as solid liquid nanoparticles, nano emissions and microemulsions. [130] Myrtenal, being a compound of lipophilic nature, prevents aqueous degradation in a biological system.…”

Section: • Inhibits Aberrant Crypt Foci (Acf) Formation In Colonmentioning

confidence: 99%

“…[ 31 ] Myrtenal has been used for treating several medical conditions such as depression, Alzheimer's, neurodegenerative diseases, renal disorders, liver cancer, colon cancer, oral cancer and bladder cancer. [ 31,32 ] Various studies with myrtenal provide a vast array of information about its mechanism of action in major signalling pathways that determine the antioncogenic and tumour suppressor property by directly influencing the receptor ligand combination. [ 33 ] It is of much importance to highlight the tumour suppressor property of myrtenal in colon cancer by its natural therapeutic nature that has been studied in preclinical experimental models of colon cancer.…”

Section: Myrtenalmentioning

confidence: 99%

“…In connection to this studies carried out with myrtenal exhibited inhibitory effect against EGFR and VEGF based on its properties such as antihyperglycemic, antioxidant, anticancer and immunostimulatory properties as well as acting as a potential inhibitor of acetylcholinesterase. [ 32 ] Signalling pathways involved in bladder cancer such as NF‐JB, Janus kinase (JAK)‐signal transducer and activator of transcription (STAT) pathways, are triggered by pro‐inflammatory receptors which alters the single transduction pathways and induce tumour growth. [ 98 ] The JAK/STAT3 pathway significantly activates STAT3 protein and leads to modification and translocation in the nucleus, targeting promoter sequences of the DNA to induce and regulate expression of apoptotic genes.…”

Section: Myrtenalmentioning

confidence: 99%

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Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Boopathy,

Roy,

Gopal

et al. 2023

J Biochem & Molecular Tox

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Colon cancer is a serious health problem across the globe with various dietary lifestyle modifications. It arises as an inflammation mediated crypts in the colon epithelial cells and undergoes uncontrolled cell division and proliferation. Bacterial enzymes contribute to a major outbreak in colon cancer development upon the release of toxic metabolites from the gut microflora. Pathogen associated molecular patterns and damage associated molecular patterns triggers the NLPR3 inflammasome pathways that releases pro‐inflammatory cytokines to induce cancer of the colon. Contributing to this, specific chemokines and receptor complexes attribute to cellular proliferation and metastasis. Bacterial enzymes synergistically attack the colon mucosa and degenerate the cellular integrity causing lysosomal discharge. These factors further instigate the Tol like receptors (TLRs) and Nod like receptors (NLRs) to promote angiogenesis and supply nutrients for the cancer cells. Myrtenal, a monoterpene, is gaining more importance in recent times and it is being widely utilized against many diseases such as cancers, neurodegenerative diseases and diabetes. Based on the research data's, the reviews focus on the anticancer property of myrtenal by emphasizing its therapeutic properties which downregulate the inflammasome pathways and other signalling pathways. Combination therapy is gaining more importance as they can target every variant in the cellular stress condition. Clinical studies with compounds like myrtenal of the monoterpenes family is provided with positive results which might open an effective anticancer drug therapy. This review highlights myrtenal and its biological potency as a cost effective drug for prevention and treatment of colon cancer.

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Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

Mathur,

Meena,

Luqman

2023

Phytotherapy Research

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Monoterpenoids, a sub‐class of terpenoids, are secondary metabolites frequently extracted from the essential oils of aromatic plants. Their antitumor properties including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects along with other biological activities have been the subject of extensive study due to their diverse characteristics. In recent years, numerous investigations have been conducted to understand its potential anticancer impacts, specifically focusing on antiproliferative and apoptotic mechanisms. Metastasis, a malignancy hallmark, can exert either protective or destructive influences on tumor cells. Despite this, the potential antimetastatic and antiangiogenic attributes of monoterpenoids need further exploration. This review focuses on specific monoterpenoids, examining their effects on metastasis and relevant signaling pathways. The monoterpenoids exhibit a high level of complexity as natural products that regulate metastatic proteins through various signaling pathways, including phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin, mitogen‐activated protein kinase/extracellular signal‐regulated kinase/jun N‐terminal kinase, nuclear factor kappa B, vascular endothelial growth factor, and epithelial mesenchymal transition process. Additionally, this review delves into the biosynthesis and classification of monoterpenoids, their potential antitumor impacts on cell lines, the plant sources of monoterpenoids, and the current status of limited clinical trials investigating their efficacy against cancer. Moreover, monoterpenoids depict promising potential in preventing cancer metastasis, however, inadequate clinical trials limit their drug usage. State‐of‐the‐art techniques and technologies are being employed to overcome the challenges of utilizing monoterpenoids as an anticancer agent.

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Chemopreventive Potential of Myrtenal against Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis

Cited by 4 publications

References 44 publications

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

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