Chemopreventive Effects of Hydatid Disease on Experimental Breast Cancer

Abstract

Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.

Employing Parasite Against Cancer: A Lesson From the Canine Tapeworm Echinococcus Granulocus

“…In addition, simultaneously injection of alive protoscolices and melanoma cell could result in significantly reduced tumor growth compared with control group in a mouse model (Chookami et al, 2014). Similarly, intraperitoneal hydatidosis established by infection of protoscolices could inhibit DMBA-induced mammary tumorigenesis in rats (Altun et al, 2015). As an indirect evidence, sera from patients with hydatid disease was cytotoxic to lung cancer cell line but had no effect on fibroblast cells (Karadayi et al, 2013).…”

Echinococcus granulosus: Cure for Cancer Revisited

“…An experimental breast cancer model study, where rats had induced mammary carcinogenesis, showed that animals 20 days post echinococcosis infection showed reduced tumor growth compared with uninfected rats ( 21 ). Overall, these studies suggest that some E .…”

Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms

“…While some species of helminths are known to be the causative agents of cancer, such as Opisthorchis felineus ( 5 ) and Schistosoma haematobium ( 6 ), there are some examples of helminths which may have the opposite effect. Indeed, the infection with Echinococcus granulosus has already shown the ability to protect against breast cancer in a rat model ( 7 ). Moreover, a Kunitz-type protease inhibitor from the same tapeworm induced apoptosis of several cancer cells while not affecting healthy ones ( 8 ).…”