Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis

Selvendiran, K.; Sakthisekaran, Dhanapal

doi:10.1016/j.biopha.2003.08.027

Cited by 64 publications

(34 citation statements)

References 23 publications

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“…The activity of Na + /K + ATPases can also be regulated by hormones, proteins and secondary messengers. The activities of Na + /K + ATPases are highly susceptible to the lipid peroxidation, which often is generated, in cancerous condition (Selvendiran and Sakthisekaran, 2004). In the present investigation, the levels of Na + /K + ATPases has found to be decreased significantly in erythrocyte membrane and in liver of the cancer bearing animals.…”

Section: +supporting

confidence: 47%

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Rajamanick¹,

Selvaraj²,

Satyavani³

et al. 2015

International J. of Cancer Research

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Acanthus ilicifolius (Acanthaceae) has received considerable attention due to its wide range of traditional usage in Indian system of medicine. The chemopreventive effect of ethanol extracts of Acanthus ilicifolius (AIEE) on N-nitrosodiethylamine (DEN, 200 mg kgG 1 )-induced experimental liver tumour was investigated in male Wistar rats. Experimental rats were orally treated with AIEE (400 mg kgG 1 b.wt.) for 1 week before the injection of diethyl nitrosamine and continued to be 14 weeks. The changes of lipid peroxidation, antioxidants and membrane bound enzymes were studied in AIEE treated experimental and control rats. The result indicates AIEE treatment effectively suppressed liver tumour induced with DEN as revealed by decrease in the levels of extend of alanine transaminase, aspartate transaminase, alkaline phosphatase, lipid peroxidase, glutathione peroxidase and glutathione-S-transferase with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumour bearing rats. The result of the study concludes significant chemopreventive effect of AIEE against DEN induced liver tumour.

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Section: +supporting

confidence: 47%

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Rajamanick¹,

Selvaraj²,

Satyavani³

et al. 2015

International J. of Cancer Research

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“…Oxidative stress in the system alters the activities of membrane bound enzymes, which is assumed to be crucial for cell lysis (Thirunavukarasu and Sakthisekaran, 2003). It has been reported that alterations in red cell fragility can cause change in Na + /K + -ATPase activity (Selvendiran and Sakthisekaran, 2004). Lowered activity of erythrocyte membrane Na + /K + -ATPase in oral cancer bearing hamsters is probably due to increased membrane lipidperoxidation.…”

Section: Discussionmentioning

confidence: 99%

Protective role of Withaferin-a on red blood cell integrity during 7,12-dimethylbenz[A]anthracene induced oral carcinogenesis

Manoharan¹,

Panjamurthy²,

Pugalendi³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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The aim of the present study was to investigate the protective effect of Withaferin-A on red blood cell integrity during 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis. The protective effect of Withaferin-A was assessed by measuring the status of glycoconjugates, membrane bound enzyme activity and red blood cell osmotic fragility. Oral squamous cell carcinoma was induced in the buccal pouch of Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin thrice a week for 14 weeks. The levels of glycoconjugates, membrane bound enzyme activity, osmotic fragility and thiobarbituric acid reactive substances (TBARS) were analyzed by using specific colorimetric methods. We observed 100% tumor formation in DMBA painted hamsters. Increase in plasma glycoconjugates at the expense of red blood cell membrane glycoconjugates levels were observed in DMBA painted hamsters as compared to control hamsters. Erythrocytes from DMBA painted hamsters were more fragile than those from control hamsters. The activity of membrane bound enzyme (Na + K + ATPase) decreased whereas TBARS level was increased in DMBA painted hamsters as compared to control hamsters. Oral administration of Withaferin-A at a dose of 20mg kg -1 bw significantly prevented the tumor formation as well as normalized the biochemical variables in DMBA painted hamsters. Our results thus demonstrate the protective effect of Withaferin-A on red blood cell integrity during DMBA induced oral carcinogenesis.

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“…Piper nigrum was found to prevent the oxidative stress by inhibiting lipid peroxidation, human lipoxygenase and arresting hydroxyl and superoxide free radicals, decrease lung carcinogenesis in animal studies. The memoryenhancing and antioxidant proprieties of the methanolic extract of Piper nigrum L. fruits at a doses of 50 and 100 mg/kg, orally, for 21 days in amyloid beta (1-42) were investigated in Alzheimer's disease model in rats [14][15][16]. The memory-enhancing effects of the extract were studied by means of in vivo (Y-maze and radial arm-maze tasks) approaches.…”

Section: Antioxidant Activity Of Black Peppermentioning

confidence: 99%

“…The alcoholic extract of peppercorn and piperine exhibited effective immunomodulatory and antitumor activities. Piperine is also reported to reduce the lung cancer by altering lipid peroxidation and by antioxidative protection enzymes activation [1,[15][16]. Piperine has distinct pharmacological activities along with Anti-cancer activity.…”

Section: Anti-cancer Activity Of Black Peppermentioning

confidence: 99%

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri

Ahmad²

2014

Medicinal Aromatic Plants

153

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Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis

Cited by 64 publications

References 23 publications

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Protective role of Withaferin-a on red blood cell integrity during 7,12-dimethylbenz[A]anthracene induced oral carcinogenesis

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

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