Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Rajamanick, E.; Selvaraj, Gurudeeban; Satyavani, K.; Ramanathan, T.

doi:10.3923/ijcr.2016.1.16

Cited by 6 publications

(3 citation statements)

References 62 publications

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“…Most previous reports were limited to cases in Western countries and the USA. Studies have reported that the annual incidence of ovarian cancer varies with race [8, 40, 41]. The genetic background and heredity of patients may be associated with different frequencies of histological subtypes and FIGO stage and thus influence prognosis.…”

Section: Discussionmentioning

confidence: 99%

Age is associated with prognosis in serous ovarian carcinoma

Deng

et al. 2017

J Ovarian Res

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PurposeThe survival duration of elderly patients with epithelial ovarian carcinoma is shorter than that of their younger counterparts. This variation in survival duration is likely attributed to differences in the distribution of histological type or grade, International Federation of Gynecology and Obstetrics (FIGO) staging, and undertreatment, but this observation remains controversial. This study aimed to investigate the biological factors other than selection bias associated with the decreased survival of elderly patients with ovarian carcinoma.MethodsA total of 314 serous ovarian cancer (SOC) patients from Jiangsu Institute of Cancer Research (JICR, PRC) between 2002 and 2012 were retrospectively analyzed, and 774 cases from MD Anderson Cancer Center (MDACC, USA) between 1992 and 2012 were used for validation. The 8-hydroxy-2′-deoxyguanine (8-OHdG) concentration in leukocyte DNA was evaluated by using commercially available enzyme-linked immunosorbent assay kits, and tissue expression was assayed through immunohistochemistry. The associations between survival durations and covariates were assessed by using a Cox proportional hazards model and by conducting a log-rank test.ResultsAdvanced age ≥ 65 years was correlated with high histological grade (p = 0.02), performance status (p = 0.03), primary treatment (p = 0.00), and suboptimal surgery outcome (p = 0.04) in SOC patients from JICR. Age, FIGO stage, histological grade, and optimal surgery were independently associated with the progression-free survival (PFS; p = 0.03, p = 0.03, p = 0.02, and p = 0.04, respectively) and overall survival (OS; p = 0.02, p = 0.04, p = 0.02, and p = 0.02, respectively) of the SOC patients from JICR. The 8-OHdG concentration in the leukocyte DNA was higher in the elderly patients than in the younger cases. The high 8-OHdG concentration in the leukocyte DNA indicated poorer median OS (30.0 months, confidence interval [CI]: 23.5–36.5 vs. 42.8 months, [CI] 38.3–47.2) and PFS (14.6 months, [CI] 11.9–17.2 vs. 18.9 months, [CI] 14.4–23.4) than those of their corresponding counterparts in the SOC patients who achieved a clinical complete response from primary treatment.ConclusionsCompared with younger cases, elderly patients with SOC were commonly characterized by high tumor grade, poor performance status, and undertreatment. High 8-OHdG concentration in leukocyte DNA was associated with advanced age and poor prognosis in SOC patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-017-0331-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Age is associated with prognosis in serous ovarian carcinoma

Deng

et al. 2017

J Ovarian Res

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“…Na+/K+, Ca 2+ , and Mg 2+ ATPases play a key role in the transportation of the electrolytes sodium, potassium, calcium, and magnesium across membranes [203]. The lipid peroxidation activity, which is often raised when in a cancerous state, plays a deleterious effect on ATPase activities and electrolyte levels [204], while electrolyte imbalance contributes to cancer progression [205]. Rutin reverses common electrolyte abnormalities, including hyperkalemia, hyponatremia, hypercalcemia, and hypomagnesemia in hepatocellular carcinoma-bearing rats [151].…”

Section: Rutin and Liver Cancermentioning

confidence: 99%

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Nouri

Fakhri

Nouri

et al. 2020

Cancers

118

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Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used in cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence, the discovery and development of novel multi-targeted agents to attenuate the dysregulated signaling in cancer is of great importance. In recent decades, phytochemicals from dietary and medicinal plants have been successfully introduced as alternative anticancer agents due to their ability to modulate numerous oncogenic and oncosuppressive signaling pathways. Rutin (also known as rutoside, quercetin-3-O-rutinoside and sophorin) is an active plant-derived flavonoid that is widely distributed in various vegetables, fruits, and medicinal plants, including asparagus, buckwheat, apricots, apples, cherries, grapes, grapefruit, plums, oranges, and tea. Rutin has been shown to target various inflammatory, apoptotic, autophagic, and angiogenic signaling mediators, including nuclear factor-κB, tumor necrosis factor-α, interleukins, light chain 3/Beclin, B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein, caspases, and vascular endothelial growth factor. A comprehensive and critical analysis of the anticancer potential of rutin and associated molecular targets amongst various cancer types has not been performed previously. Accordingly, the purpose of this review is to present an up-to-date and critical evaluation of multiple cellular and molecular mechanisms through which the anticancer effects of rutin are known to be exerted. The current challenges and limitations as well as future directions of research are also discussed.

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“…proficiency of STZ to assist production of free radicals and causes oxidative stress [7]. The increase of reactive oxygen species (ROS) from the reaction of enzymes, metabolism of xenobiotics shows the way to lipid peroxidation with consecutive cell disruption and toxicity [8]. Free radical increases in liver and kidney tissues may accommodate almost absorption of per-oxidize-able fatty acids.…”

Section: Journal Of Complementary Medicine and Alternative Healthcarementioning

confidence: 99%

Untitled

2018

JCMAH

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Oxidative stress is responsible for impairment of β-cells caused by chronic glucose toxicity. The present study demonstrates dichloromethane fraction (DCM-F) of Rhizophora mucronata mediated fortification against diabetes mellitus induced alterations in antioxidant defense system in the animal model. Single intraperitoneal injection of streptozotocin and nicotinamide was to induce diabetes in rats. 50mg/kg of DCM-F was orally treated to diabetic rats for 45 days. At the end of the experiment, blood glucose, lipid hydro-peroxide (LH), plasma enzymatic and nonenzymatic antioxidants were determined. Treatment of DCM-F to the experimental rats notably (p<0.01) restored blood-glucose, body weight, lipid profile and carbohydrate metabolic enzyme activities. Besides, the intensity of LH increased and CAT, glutathione peroxidase (GPx), GSH, and SOD were considerably decreased in diabetic rats. These unfavourable alterations were inverted to normal in DCM-F treated rats. Moreover, notable results on ceruloplasmin, ascorbic acid, and tocopherol were observed in DCM-F treatment as differenced with diabetic and control. In conclusion, DCM-F of R. mucronata act as antioxidant linked with anti-hyperglycemic and act as a ligand for selected antioxidant receptors.

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Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Cited by 6 publications

References 62 publications

Age is associated with prognosis in serous ovarian carcinoma

Age is associated with prognosis in serous ovarian carcinoma

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

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