Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides

Abstract

Background: The fish oil-derived ω-3 fatty acids, like docosahexanoic (DHA), claim a plethora of health benefits. We currently evaluated the antitumor effects of DHA, alone or in combination with cisplatin (CP) in the EAC solid tumor mice model, and monitored concomitant changes in serum levels of C-reactive protein (CRP), lipid peroxidation (measured as malondialdehyde; MDA) and leukocytic count (LC). Further, we verified the capacity of DHA to ameliorate the lethal, CP-induced nephrotoxicity in rats and the molecular mechanisms involved therein.

The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

“…The mean serum sodium concentration in all experimental groups receiving omega-3 fish oil supplement and thioacetamide showed a significant decrease compared to the group receiving thioacetamide.This means that the omega-3 fish oil supplement has protective effects on kidney cells against the damage caused by thioacetamide, a fact which was also confirmed in histopathological studies. In general, the results of this study are in line with the results of other researchers [19].…”

Protective Effect of Docosahexaenoic Acid Against Cyclosporine A-Induced Nephrotoxicity in Rats: A Possible Mechanism of Action

“…It also increased Ccr and serum total protein when compared with the untreated CsA-intoxicated animals ( Table 1). This is consistent with previous findings of Sabry et al, 39 Kim and Chung, 41 and El-Mesery et al, 42 who have demonstrated the protective renal effect of omega-3 fatty acids.…”

Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

“…Less attention has been given to nutritional treatment using cod liver oil. In addition, we have previously shown that DHA can obliterate lethal cisplatin-induced nephrotoxicity and renal tissue injury by reducing oxidative stress in rats and mice (El-Mesery et al, 2009). Moreover, we found that daily treatment of nonalcoholic fatty liver patients with fish oil, which contains both DHA and EPA, for 6 months, improved lipid profiles and ameliorated oxidative stress (Al-Gayyar et al, 2012).…”

“…These antioxidant effects of cod liver oil can be attributed to its omega-3 fatty acids and vitamin A contents. Many previous studies showed strong antioxidant activity of omega-3 fatty acids in different models (Al-Gayyar et al, 2012;Diggle, 2002;El-Mesery et al, 2009;Mesa et al, 2004). In addition, cod liver oil is a good source of vitamin A supplementation.…”