Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract

Ajani, Emmanuel Oladipo; Salako, AA; Sharlie, P.D.; Akinleye, W.A.; Adeoye, Adewunmi; Salau, Bamidele Adewale; Adebawo, Olugbenga O.

doi:10.1016/j.jep.2009.02.006

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Thus, the major part of the anti-inflammatory properties of H. bonariensis could be due to the saponin content. The phytochemicals detected in this study are in agreement with those reported by Ajani (2012). Hexadecanoic acid methyl ester, falcarinol and phytol which are compounds that have been reported to exert anti-inflammatory effects were three of the major compounds suggested in the hexane extract of H. bonariensis leaves.…”

Section: Discussionsupporting

confidence: 91%

“…The study also indicated that when administered at an acute dose, the extract may not potentiate any significant toxic effect. It has also been reported that H. bonariensis possesses significant antioxidant property that may offer protection from galactose induced oxidative damage in both the lens and the liver (Ajani, 2012).…”

Section: Introductionmentioning

confidence: 98%

“…The anti-mutagenic activity of the aqueous and methanolic extracts from the leaves and stems has been reported (Florinsiah et al, 2013). Results obtained in a study by Ajani (2012), suggested that chronic administration of H. bonariensis aqueous leaf extract may not contribute to liver and renal dysfunction. The study also indicated that when administered at an acute dose, the extract may not potentiate any significant toxic effect.…”

Section: Introductionmentioning

confidence: 99%

“…There are approximately 402 species in this genus and they are mostly found in Africa and America. Its common name in West Africa, Nigeria is Karo (Ajani, 2012). It is well known for its traditional uses and medicinal properties for the treatment of various kinds of diseases such as tuberculosis, relieving the pains of inflammation, rheumatism and arthritis, to increase brain capacity and for longevity (Masoumian et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…This herb has its medicinal uses as emetics, diuretics and laxatives (Evans, 1992). Leaves of this plant have been reported to contain alkaloids, flavonoids, tannins, phenolics and saponins (Ajani, 2012). The anti-mutagenic activity of the aqueous and methanolic extracts from the leaves and stems has been reported (Florinsiah et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves

Obaseki¹,

Adesegun²,

Anyasor³

et al. 2016

Afr. J. Biotechnol.

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This study investigates the anti-inflammatory properties of Hydrocotyle bonariensis Comm. Ex Lam, a medicinal plant used by indigenous traditional healers to manage chronic inflammatory diseases especially rheumatism and arthritis. The hexane extract of H. bonariensis leaves was evaluated for the presence and concentration of phytochemicals. It was subjected to heat-induced albumin denaturation and human red blood cell (HRBC) membrane stabilization assays. The anti-inflammatory properties of the extract were further assessed by employing the formaldehyde induced arthritis animal model assay. The extract was finally subjected to GC/MS analysis for the tentative identification of the phytochemical constituents. Phytochemical analysis of the extract revealed the presence of saponin, phenol, flavonoid, tannin, terpenoid and sterol. This extract showed the ability to inhibit thermally-induced protein denaturation and stabilize HRBC membrane in concentration dependent manner. In the formaldehyde induced arthritis model, the paw measurements of the rats were taken, their hematological parameters were determined, and their liver function tests (aspartate aminotransferase and alanine aminotransferase activities) were also carried out. Results from the animal model indicated that oral administration of the hexane extract of H. bonariensis leaf at a dose of 250 mg/kg body weight had potent anti-inflammatory action. The GC/MS analysis suggested a number of anti-inflammatory compounds in the extract among which were: hexadecanoic acid methyl ester, falcarinol and phytol. Consequently, the tentative identification of phytochemicals with anti-inflammatory activity in H. bonariensis affirms the anti-inflammatory property of the plant and the phytochemicals could serve as lead compounds for designing anti-inflammatory drugs.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves

Obaseki¹,

Adesegun²,

Anyasor³

et al. 2016

Afr. J. Biotechnol.

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Simplified Derivatives of Dibenzylbutyrolactone Lignans from Hydrocotyle bonariensis as Antitrypanosomal Candidates

Souza

Costa-Silva

Morais

et al. 2021

Chemistry & Biodiversity

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The search for the pharmacophore of a bioactive compound, crucial for drug discovery studies, involves the adequate arrangement of different atoms in the molecule. As part of a continuous work aiming discovery of new drug candidates against the protozoan parasite Trypanosoma cruzi, the hexane extract of Hydrocotyle bonariensis was subjected to a bioactivity‐guided fractionation to afford two chemically related dibenzylbutyrolactone lignans – hinokinin (1) and hibalactone (2). Compounds 1 and 2 showed activity against trypomastigote with EC50 values of 17.0 and 69.4 μM, respectively. Compound 1 was also active against the clinically relevant form of the parasite, amastigotes, displaying an EC50 value of 34.4 μM. The structure‐activity relationship (SAR) indicated that the absence of the double bond at C‐7 is a crucial feature for the increment of the antiparasitic activity. The lethal action of the most potent compound 1 was investigated in the trypomastigotes. The fluorescent‐based assay with SYTOX Green demonstrated a significant alteration of the plasma membrane permeability of the parasite. Additionally, compound 1 demonstrated no significant hemolytic activity in mice erythrocytes at 200 μM. To search the pharmacophore, three different simplified compounds – 3,4‐methylenedioxydihydrocinnamic acid (3), 3,4‐methylenedioxydihydrocinnamic alcohol (4) and 3,4‐methylenedioxycinnamic acid (5) – were prepared and tested against T. cruzi. These derivatives displayed EC50 values of 37.2 (3), 25.8 (4) and 73.5 (5) μM against trypomastigotes, and 41.3 (3) and 48.2 (4) μM against amastigotes, whereas compound 5 was inactive. Except for compound 2, which resulted in a CC50 value of 114.5 μM, all compounds showed no mammalian cytotoxicity at 200 μM. An in silico ADMET study was performed and predicted values demonstrated an acceptable drug‐likeness profile for compounds 1–5. Despite the minor reduction in the potency, the simplified derivatives retained the antitrypanosomal activity against the intracellular amastigotes, even with 95 % reduction of their molecular weight. Additionally, in silico studies suggested them as more soluble compounds, making these simplified structures promising scaffolds for optimization studies in Chagas disease.

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Etiology and Prevention of Cataract

Kumari

Ramkumar

Thankappan

et al. 2014

Oxidative Stress in Applied Basic Research and Clinical Practice

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Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract

Cited by 15 publications

References 32 publications

Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves

Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves

Simplified Derivatives of Dibenzylbutyrolactone Lignans from Hydrocotyle bonariensis as Antitrypanosomal Candidates

Etiology and Prevention of Cataract

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