Etiology and Prevention of Cataract

Kumari, Rasiah Pratheepa; Ramkumar, Srinivasagan; Thankappan, Bency; Anbarasu, Kumarasamy

doi:10.1007/978-1-4939-1935-2_16

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Crystalline Lens and Age-related Cataract1

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2023

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“…Lens aggregates can alter light transmission [61] and can ultimately appear as biomicroscopically visible opacification. As such, aggregation and insolubilization of crystallins cause the degeneration and opacification of the lens, inducing cataractogenesis [62][63][64]. Although cataract is a well-known disease, the mechanism(s) of eye lens protein aggregation is not well understood.…”

Section: Crystalline Lens and Age-related Cataractmentioning

confidence: 99%

Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases

Greiner,

Glonek

2023

Metabolites

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Protein aggregation is the etiopathogenesis of the three most profound vision-threatening eye diseases: age-related cataract, presbyopia, and age-related macular degeneration. This perspective organizes known information on ATP and protein aggregation with a fundamental unrecognized function of ATP. With recognition that maintenance of protein solubility is related to the high intracellular concentration of ATP in cells, tissues, and organs, we hypothesize that (1) ATP serves a critical molecular function for organismal homeostasis of proteins and (2) the hydrotropic feature of ATP prevents pathological protein aggregation while assisting in the maintenance of protein solubility and cellular, tissue, and organismal function. As such, the metabolite ATP plays an extraordinarily important role in the prevention of protein aggregation in the leading causes of vision loss or blindness worldwide.

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Section: Crystalline Lens and Age-related Cataractmentioning

confidence: 99%