Chemoprevention of cancer

Sporn, Michael B.; Suh, Nanjoo

doi:10.1093/carcin/21.3.525

Cited by 393 publications

(193 citation statements)

References 30 publications

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“…34 Several anabolic enzymes such as DNA polymerase, ribonucleotide reductase, FAS, etc are overexpressed in cell proliferation and tumor development. [35][36][37] Numerous studies have demonstrated the striking similarity between the tumor promotion process in Figure 6 A proposed mechanism for the suppression of EGCG and TF-3 on the expression of FAS through modulation of the EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway. Abbreviations are: EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; PI3K, phosphotidylinositol-3-kinase; PDK, phosphotidylinositol-3, 4, 5-triphosphate-dependent kinase; EGCG, epigallocatechin-3-gallate; TF-3, theaflavin-3,3 0 -digallate.…”

Section: Discussionmentioning

confidence: 98%

Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects

et al. 2003

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Tea is a heavily consumed beverage world wide because of its unique aroma, less cost and broad availability. Fatty acid synthase (FAS) is a key enzyme in lipogenesis. FAS is overexpressed in the malignant human breast carcinoma MCF-7 cells and its expression is further enhanced by the epidermal growth factor (EGF). The EGF-induced expression of FAS was inhibited by green and black tea extracts. The expression of FAS was also suppressed by the tea polyphenol (À)-epigallocatechin 3-gallate (EGCG), theaflavin (TF-1), TF-2 and theaflavin 3,3 0 -digallate(TF-3) at both protein and mRNA levels that may lead to the inhibition of cell lipogenesis and proliferation. Both EGCG and TF-3 inhibit the activation of Akt and block the binding of Sp-1 to its target site. Furthermore, the EGF-induced biosyntheses of lipids and cell proliferation were significantly suppressed by EGCG and TF-3. These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/ PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS.

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Section: Discussionmentioning

confidence: 98%

Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects

et al. 2003

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“…Recent advances in defining cellular and molecular levels of carcinogenesis, along with a growing body of experimental epidemiological, and clinical trial data, have led to the development of cancer chemoprevention, a relatively new strategy in preventing cancer. [4] Beside the control of causative exogenous factors, such as cigarette smoking, dietary factors, and specific microorganisms, cancer chemoprevention can play an integral role in the overall strategy geared toward reducing the incidence of cancer. [4] Rational and successful implementation of chemopreventive strategies relies intrinsically on tests for efficacy and mechanistic assays, as well as availability of promising chemopreventive agents, reliable intermediate biomarkers, and appropriate clinical cohorts to discover safe and effective drugs for primary and secondary prevention of human cancers.…”

Section: Cancer Chemoprevention Using Phytonutrientsmentioning

confidence: 99%

Advanced Methods for Natural Product Drug Discovery in the Field of Nutraceuticals

Wolfender

Eugster

Bohni

et al. 2011

Chimia

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Advances in analytical methods and bioassay development have helped to push forward the research in natural products. In plant extracts and nutraceuticals, bioactive compounds are part of a complex mixture. The development of high-resolution methods related to HPLC for both chemical and biological profiling has significantly increased the efficiency of classical bioactivity-guided fractionation procedures. Furthermore, the level of sensitivity obtained by these methods give the possibility to work with few micrograms of compound. This represents a key advantage for rapid localisation of the biological activity and subsequent identification of the compounds of interest. The same methods are also used to study the extracts from a metabolomic view point. The possibility to study them as a whole can highlight synergetic effects, which are likely to occur in plant extracts and nutraceuticals. In this paper, the main trends are summarised and the developments made in our laboratory on profiling crude extracts with UHPLC-TOF-MS, natural product identification at the microgram level using microflow NMR and integration of these methods with biological evaluation are highlighted.

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“…Natural products contain a wide variety of chemical compounds that have potent biological effects, including anticancer activity (1). Identification of the active components and their mechanism of action is important to assess their potential for clinical use and possible diverse side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Despite recent clinical advances, colon carcinoma still remains a major issue because of its incidence, morbidity, and mortality (4,8,9). One promising approach to reduce the incidence and improve the prognosis of this malignancy may be chemoprevention (1,10).…”

Section: Introductionmentioning

confidence: 99%

Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines

Ishihara

Naoi²,

Hashita³

et al. 2009

Oncol Rep

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Abstract. More than 300 bio-active compounds have been identified from bee propolis in various regions of the world. The objective of this study was to examine whether the ethanol extracts of Chinese and Brazilian propolis may exert anticancer activities in four human colon carcinoma cell lines, namely CaCo2, HCT116, HT29 and SW480. Propolis samples were extracted with ethanol, and the crude extracts were dissolved in dimethylsulfoxide and used for the experiments. In HCT116, HT29 and SW480 cell lines, the extracts of both Chinese and Brazilian propolis caused a marked dose-dependent growth inhibition, with IC 50 values in the range of 4-41 μg/ml. In HCT116 cell line, Chinese propolis extract induced apoptosis in the cells after 72 h of treatment. In addition, Chinese propolis extract caused a dose-dependent increase in the cellular mRNA levels of p21 CIP1 and p53 in the HCT116 cell line. These findings indicate that the ethanol extracts of propolis contain components that may have anticancer activity. Thus, propolis and related products may provide a novel approach to the chemoprevention and treatment of human colon carcinoma. IntroductionThere is growing interest in the use of natural products to aid in the maintenance of human health. Natural products contain a wide variety of chemical compounds that have potent biological effects, including anticancer activity (1). Identification of the active components and their mechanism of action is important to assess their potential for clinical use and possible diverse side effects. Propolis is a natural product derived from various plant resins collected by honeybees, and has been used as a folk medicine for centuries in Europe, North and South America, China and Japan (2). Propolis has been reported to exhibit a broad spectrum of activities including antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, hepatoprotective, and anticancer properties (2,3). Propolis from Europe, North and South America, Asia and Africa differ in their composition because of the differences in the local vegetation (2,3). The medical application of propolis has led to increased interest in its chemical compositions and its botanical origins since polyphenol compounds and their derivatives have been identified in propolis (2,3).Colon carcinoma is a common malignancy ranking third in frequency on a world wide basis and causes about 500,000 deaths annually (4). This malignancy is most common in developed countries of Western world, and mortality rate of this disease is rising (4). It is thought that one-third of human carcinoma might be associated with dietary habits and lifestyle (5) and dietary factors are known to be critical modulators of the development of human colon carcinoma (6,7). Despite recent clinical advances, colon carcinoma still remains a major issue because of its incidence, morbidity, and mortality (4,8,9). One promising approach to reduce the incidence and improve the prognosis of this malignancy may be chemoprevention (1,10).Although the above-described fi...

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Chemoprevention of cancer

Cited by 393 publications

References 30 publications

Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects

Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects

Advanced Methods for Natural Product Drug Discovery in the Field of Nutraceuticals

Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines

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